scholarly journals THE EFFECTS OF ALTERED ARTERIAL TENSIONS OF CARBON DIOXIDE AND OXYGEN ON CEREBRAL BLOOD FLOW AND CEREBRAL OXYGEN CONSUMPTION OF NORMAL YOUNG MEN 1

1948 ◽  
Vol 27 (4) ◽  
pp. 484-492 ◽  
Author(s):  
Seymour S. Kety ◽  
Carl F. Schmidt
1993 ◽  
Vol 79 (4) ◽  
pp. 666-671 ◽  
Author(s):  
Karsten Skovgaard Olsen ◽  
Charlotte Videbaek ◽  
Niels Agerlin ◽  
Martin Kroll ◽  
Torben Boge-Rasmussen ◽  
...  

1953 ◽  
Vol 32 (8) ◽  
pp. 696-702 ◽  
Author(s):  
Paul Novack ◽  
Henry A. Shenkin ◽  
Leonard Bortin ◽  
Bernard Goluboff ◽  
Alvin M. Soffe ◽  
...  

1976 ◽  
Vol 231 (2) ◽  
pp. 489-494 ◽  
Author(s):  
ET MacKenzie ◽  
J McCulloch ◽  
AM Harper

The influence of brain norepinephrine on cerebral metabolism and blood flow was examined because exogenous norepinephrine, administered in a way that the blood-brain barrier is bypassed, has been shown to effect pronounced changes in the cerebral circulation. Reserpine (40 mug/kg, by intracarotid infusion) was administered in order to release brain norepinephrine in five anesthetized baboons. Reserpine significantly increased cerebral oxygen consumption (23%) and cerebral blood flow (50%). This response lasted for approximately 60 min. In a further five animals, effects of central beta-adrenoreceptor blockade were studied. Pro pranolol (12 mug/kg-min) produced an immediate, significant reduction in both cerebral oxygen consumption (40%) and cerebral glucose uptake (39%). Cerebral blood flow was reduced minimally. However, the responsiveness of the cerebral circulation to induced hypercapnia was severely attenuated from a gradient of 3.22 before, to 1,11 after, administration. These experiments suggest that central norepinephrine can influence the cerebral circulation primarily through noradrenergic effects on brain metabolism.


1989 ◽  
Vol 70 (2) ◽  
pp. 255-260 ◽  
Author(s):  
Michel Pinaud ◽  
Réml Souron ◽  
Jean-Noël Lelausque ◽  
Marie-France Gazeau ◽  
Youenn Lajat ◽  
...  

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