scholarly journals Anticonvulsant hypersensitivity syndrome. In vitro assessment of risk.

1988 ◽  
Vol 82 (6) ◽  
pp. 1826-1832 ◽  
Author(s):  
N H Shear ◽  
S P Spielberg
Keyword(s):  
Hypersensitivity Syndrome ◽  
Anticonvulsant Hypersensitivity Syndrome ◽  
In Vitro Assessment

Evidence for a T-Lymphocyte Dependent Mechanism Involving Proinflammatory Cytokines in Anticonvulsant Hypersensitivity Syndrome: A Case Report

2002 ◽  
Vol 15 (3) ◽  
pp. 239-242 ◽  
Author(s):  
E. Chiappini ◽  
M. Peruzzi ◽  
L. Galli ◽  
G. Calabri ◽  
M. de Martino
Keyword(s):  
T Lymphocyte ◽  
Drug Hypersensitivity ◽  
Anticonvulsant Drug ◽  
Hypersensitivity Syndrome ◽  
Lymphocyte Response ◽  
Anticonvulsant Hypersensitivity Syndrome ◽  
Drug Hypersensitivity Syndrome ◽  
Dependent Mechanism ◽  
Pro Inflammatory Cytokines

The anticonvulsant drug hypersensitivity syndrome (AHS) is a potentially fatal drug reaction associated with aromatic antiepileptic drugs, the pathogenic mechanisms of which are still unclear. We studied a 2-year-old female affected with AHS after phenobarbital treatment. In vitro experiments showed a T-lymphocyte response to the drug and an increased, dose-related, IL-6 production after drug incubation. These findings suggest that AHS may be caused by a T-lymphocyte dependent mechanism, involving pro-inflammatory cytokines.

In Vitro Testing for the Diagnosis of Anticonvulsant Hypersensitivity Syndrome

2009 ◽  
Vol 13 (5) ◽  
pp. 313-330 ◽  
Author(s):  
Abdelbaset A. Elzagallaai ◽  
Sandra R. Knowles ◽  
Michael J. Rieder ◽  
John R. Bend ◽  
Neil H. Shear ◽  
...  
Keyword(s):  
Hypersensitivity Syndrome ◽  
In Vitro Testing ◽  
Anticonvulsant Hypersensitivity Syndrome

In vitro assessment of Labisia pumila and its constituents for interactions with CYPs, P-GP and PXR

Planta Medica ◽  
2014 ◽  
Vol 80 (10) ◽  
Author(s):  
VK Manda ◽  
OR Dale ◽  
C Awortwe ◽  
Z Ali ◽  
IA Khan ◽  
...  
Keyword(s):  
In Vitro Assessment ◽  
Labisia Pumila
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