scholarly journals ApoE knockout mice expressing human matrix metalloproteinase-1 in macrophages have less advanced atherosclerosis

2001 ◽  
Vol 107 (10) ◽  
pp. 1227-1234 ◽  
Author(s):  
Vincent Lemaître ◽  
Timothy K. O’Byrne ◽  
Alain C. Borczuk ◽  
Yasunori Okada ◽  
Alan R. Tall ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Knockout Mice ◽  
Matrix Metalloproteinase 1 ◽  
Apoe Knockout Mice

scholarly journals Angiotensin II induces extracellular matrix metalloproteinase inducer expression via an AT1R dependent pathway in aortic atherosclerotic plaque in apolipoprotein E knockout mice

2011 ◽  
Vol 13 (1) ◽  
pp. 67-75 ◽  
Author(s):  
Li-xia Yang ◽  
Zhi-hua Yang ◽  
Rui-wei Guo ◽  
Jin-shan Ye ◽  
Hong Liu
Keyword(s):  
Extracellular Matrix ◽  
Angiotensin Ii ◽  
Matrix Metalloproteinase ◽  
Protein Expression ◽  
Atherosclerotic Plaque ◽  
Knockout Mice ◽  
Ang Ii ◽  
Extracellular Matrix Metalloproteinase Inducer ◽  
Apolipoprotein E Knockout Mice ◽  
Apoe Knockout Mice

The pathogenesis of acute coronary syndrome is rupture of vulnerable plaque. Extracellular matrix metalloproteinase inducer (EMMPRIN) is reported to have a important role in the destabilization of atheroma. Objectives: this investigation examined the effect of angiotensin II (Ang II) on EMMPRIN expression in atherosclerotic plaques in ApoE knockout mice. Methods: ApoE knockout mice were fed a high fat diet to establish an atherosclerosis model then intervention was made with Ang II and valsartan. EMMPRIN gene and its protein expression were measured by real-time PCR immunohistochemistry, and Western blot. Results: EMMPRIN gene and protein expression intervened with Ang II were significantly increased; valsartan could inhibit the effect of Ang II. Conclusion: Ang II up-regulated EMMPRIN expression in atherosclerotic plaque via AT1R, and valsartan could inhibit the effect of Ang II.

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