Recent Advances in Local Thermal Ablation Therapy for Hepatocellular Carcinoma

2021 ◽  
pp. 000313482110545
Author(s):  
Min Deng ◽  
Shao-Hua Li ◽  
Rong-Ping Guo
Keyword(s):  
Hepatocellular Carcinoma ◽  
Radiofrequency Ablation ◽  
Liver Resection ◽  
Thermal Ablation ◽  
Good Choice ◽  
Local Tumor Recurrence ◽  
Ablation Therapy ◽  
First Line Therapy ◽  
Thermal Ablation Therapy ◽  
Arterial Chemoembolization

Image-guided local thermal ablation (LTA) plays an important role in the treatment of hepatocellular carcinoma (HCC), especially in patients with HCC who are not suitable for hepatectomy. Radiofrequency ablation (RFA) and microwave ablation (MWA) are the most widely used LTA clinically. Radiofrequency ablation can achieve the best result; that is, a similar therapeutic effect as hepatectomy if the tumor ≤3 cm, while MWA can effectively ablate tumors ≤5 cm. Local thermal ablation has an advantage over liver resection in terms of minimally invasive surgery and can achieve a comparable prognosis and efficacy to liver resection. For borderline liver function, selecting LTA as the first-line therapy may bring more benefits to patients with cirrhosis background. In addition, a combination of multiple therapies for HCC is a good choice, such as LTA combined with transcatheter arterial chemoembolization (TACE), which can achieve a better prognosis than single therapy for larger tumors. For patients who are awaiting liver transplantation, LTA is a good choice. The main problem of LTA needed to be solved is to prevent the local tumor recurrence after ablation in patients with HCC.

scholarly journals Transcatheter arterial chemoembolization plus radiofrequency ablation therapy for early stage hepatocellular carcinoma

Cancer ◽  
2010 ◽  
Vol 116 (15) ◽  
pp. 3638-3644 ◽  
Author(s):  
Tatehiro Kagawa ◽  
Jun Koizumi ◽  
Sei-ichiro Kojima ◽  
Naruhiko Nagata ◽  
Makoto Numata ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Radiofrequency Ablation ◽  
Transcatheter Arterial Chemoembolization ◽  
Early Stage ◽  
Ablation Therapy ◽  
Radiofrequency Ablation Therapy ◽  
Arterial Chemoembolization

scholarly journals Combined minimally invasive treatment of liver and bile ducts malignancies

2018 ◽  
Vol 23 (2) ◽  
pp. 26-36 ◽  
Author(s):  
O. V. Melekhina ◽  
Yu. V. Kulezneva ◽  
M. G. Efanov ◽  
A. B. Musatov
Keyword(s):  
Hepatocellular Carcinoma ◽  
Radiofrequency Ablation ◽  
Liver Resection ◽  
Bile Ducts ◽  
Invasive Treatment ◽  
Resection Group ◽  
Cancer Metastases ◽  
Group 3 ◽  
Group 2 ◽  
Arterial Chemoembolization

Aim. To analyze radiofrequency ablation per se and in combination with other X-ray surgical procedures in patients with liver and bile ducts malignancies. Material and methods. Radiofrequency ablation was used in three groups: percutaneous intervention or in combination with liver resection – group 1 (n = 111); ablation combined with intra-arterial chemoembolization (n = 3) – group 2; RFA followed by right portal vein embolization (RALPPES) in order to induce liver hypertrophy to enable liver resection – group 3 (n = 20). Results. There were no recurrences after radiofrequency ablation. Two-year survival was 55% in patients with hepatocellular carcinoma and liver cirrhosis.Colorectal cancer metastases were followed by 4-year survival near 55%. RFA combined with intra-arterial chemoembolization were associated with complete tumor destruction in patients with hepatocellular carcinoma over 4–5 cm and stabilization in patients with progressive intrahepatic cholangiocarcinoma. Liver hypertrophy was over 50% in two weeks after RALPPES that enables liver resection in 95% of patients. Symptoms of liver failure after hemihepatectomy were not observed in any patients. Conclusion. Combination of interventional methods is able to improve outcomes in patients with liver and bile ducts malignancies.

Liver resection for recurrent hepatocellular carcinoma after radiofrequency ablation therapy

2019 ◽  
Vol 49 (4) ◽  
pp. 432-440 ◽  
Author(s):  
Shunsuke Yamagishi ◽  
Yutaka Midorikawa ◽  
Hisashi Nakayama ◽  
Tokio Higaki ◽  
Masamichi Moriguchi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Radiofrequency Ablation ◽  
Liver Resection ◽  
Ablation Therapy ◽  
Recurrent Hepatocellular Carcinoma ◽  
Radiofrequency Ablation Therapy

Thoracoscopic Thermal Ablation Therapy for Hepatocellular Carcinoma Located Beneath the Diaphragm

Endoscopy ◽  
2001 ◽  
Vol 33 (8) ◽  
pp. 697-702 ◽  
Author(s):  
T. Ishikawa ◽  
T. Kohno ◽  
T. Shibayama ◽  
Y. Fukushima ◽  
S. Obi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Thermal Ablation ◽  
Ablation Therapy ◽  
Thermal Ablation Therapy

scholarly journals Application of Nanoparticles and Nanomaterials in Thermal Ablation Therapy of Cancer

Nanomaterials ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. 1195 ◽  
Author(s):  
Zhannat Ashikbayeva ◽  
Daniele Tosi ◽  
Damir Balmassov ◽  
Emiliano Schena ◽  
Paola Saccomandi ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Thermal Ablation ◽  
Conventional Heating ◽  
Great Promise ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Ablation Therapy ◽  
Treatment Techniques ◽  
Thermal Ablation Therapy ◽  
Heating Capacity ◽  
Tumor Region

Cancer is one of the major health issues with increasing incidence worldwide. In spite of the existing conventional cancer treatment techniques, the cases of cancer diagnosis and death rates are rising year by year. Thus, new approaches are required to advance the traditional ways of cancer therapy. Currently, nanomedicine, employing nanoparticles and nanocomposites, offers great promise and new opportunities to increase the efficacy of cancer treatment in combination with thermal therapy. Nanomaterials can generate and specifically enhance the heating capacity at the tumor region due to optical and magnetic properties. The mentioned unique properties of nanomaterials allow inducing the heat and destroying the cancerous cells. This paper provides an overview of the utilization of nanoparticles and nanomaterials such as magnetic iron oxide nanoparticles, nanorods, nanoshells, nanocomposites, carbon nanotubes, and other nanoparticles in the thermal ablation of tumors, demonstrating their advantages over the conventional heating methods.

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