Effect of Cholinergic Drugs on the Perilymphatic Oxygen Tension

1979 ◽  
Vol 88 (5) ◽  
pp. 626-629
Author(s):  
N. Yagi ◽  
U. Fisch
Keyword(s):  
Oxygen Tension ◽  
Intravenous Injection ◽  
Cholinergic Receptors ◽  
Polarographic Method ◽  
Cholinergic Drugs ◽  
Perilymphatic Space

The effect of the intravenous injection of cholinergic drugs on perilymphatic oxygen tension (Po2) was measured using the polarographic method in 20 cats. Acetylcholine, pilocarpine and neostigmine produced minimal but statistically significant changes in perilymphatic Po2. Atropine and scopolamine did not influence the Po2 of the perilymphatic space. The reported results show that under normal conditions the cholinergic receptors of the vestibular vessels have little effect on the permeability of arterial Po2.

Perilymphatic Oxygen Tension and Vasoactive Drugs

1978 ◽  
Vol 87 (3) ◽  
pp. 364-369 ◽  
Author(s):  
N. Yagi ◽  
U. Fisch ◽  
K. Murata
Keyword(s):  
Blood Pressure ◽  
Oxygen Tension ◽  
Intravenous Injection ◽  
Systemic Blood Pressure ◽  
Polarographic Method ◽  
Vasoactive Drugs ◽  
Systemic Blood ◽  
Rapid Changes ◽  
Perilymphatic Space

— The oxygenation of the perilymph in response to the intravenous injection of vasoactive drugs has been measured in 67 cats using the polarographic method. Of all drugs used, only angiotensin induced a significant raise of perilymphatic PO2. Histamine, 50% glycerol and 7% Na2CO3 reduced the perilymphatic PO2. Papaverine, furosemid, pyridylcarbinol, naftidrofuryl and low molecular dextran have no significant effect upon the perilymphatic oxygen tension. Rapid changes of systemic blood pressure were found to correlate with subsequent modifications of the oxygen tension in the perilymphatic space.

scholarly journals Oxygen Tension of Tissues by the Polarographic Method

Circulation ◽  
1950 ◽  
Vol 2 (6) ◽  
pp. 845-849 ◽  
Author(s):  
HUGH MONTGOMERY ◽  
HARRY F. ZINSSER ◽  
ORVILLE HORWITZ
Keyword(s):  
Oxygen Tension ◽  
Polarographic Method

Augmented vagal release of antral gastrin by 2-deoxyglucose after fundic vagotomy in dogs.

1979 ◽  
Vol 236 (2) ◽  
pp. E173
Author(s):  
B I Hirschowitz ◽  
R G Gibson
Keyword(s):  
Intravenous Injection ◽  
Serum Gastrin ◽  
Acid Output ◽  
Cholinergic Receptors ◽  
Gastric Fistula ◽  
Gastrin Release ◽  
Total Acid ◽  
Muscarinic Cholinergic Receptors ◽  
Single Intravenous Injection ◽  
Muscarinic Cholinergic

To study the relation between gastrin released by vagal excitation and the secretion of H+ and pepsin under various conditions, central vagal excitation was induced by 2-deoxyglucose (2DG) in doses of 50, 100, and 200 mg/kg body wt given as a single intravenous injection in seven gastric fistula dogs, three with fundic vagotomy and four with intact vagi. Serum gastrin increased linearly with dose doubling in both groups but was twice as high in the vagotomized dogs. Total acid output for 3 h was related linearly to integrated gastrin output in both groups, but the slope, H+/gastrin, was 10 times steeper in the vagally intact dogs (330 vs. 34 mueq/pg gastrin-ml-30 min) and pepsin output almost 20 times greater [5,400 peptic units (PU) vs. 296 PU]. Acidification of the antrum to pH 1.2-1.4 eliminated the gastrin response to 2DG in both groups of dogs. Atropine (100 microgram/kg iv) reduced serum gastrin in the vagotomized and increased it in the intact dogs. Atropinization uncovers stimulation by 2DG by pathways that do not involve muscarinic cholinergic receptors. Stimulation by both pathways is suppressible by acid. We conclude that fundic vagotomy removes an inhibitor of vagal gastrin release.

An Improved Polarographic Method for Measuring Oxygen Tension in Whole Blood

1957 ◽  
Vol 11 (3) ◽  
pp. 365-370 ◽  
Author(s):  
Brian J. Sproule ◽  
William F. Miller ◽  
Ivan E. Cushing ◽  
Carleton B. Chapman
Keyword(s):  
Oxygen Tension ◽  
Whole Blood ◽  
Polarographic Method

scholarly journals Effect of CO2 on the Perilymphatic Oxygen Tension in Cats

1977 ◽  
Vol 86 (2) ◽  
pp. 164-171 ◽  
Author(s):  
K. Murata ◽  
U. Fisch
Keyword(s):  
Blood Flow ◽  
Inner Ear ◽  
Oxygen Content ◽  
Oxygen Tension ◽  
Experimental Animal ◽  
Pure Oxygen ◽  
Actual Degree ◽  
Adult Cats ◽  
Perilymphatic Space ◽  
Inner Ear Fluids

A microelectrode with a tip of 100μ permitting recording of the oxygen tension in the perilymphatic space according to the polarographic principle and having a minimal drift of 1–2.5% per hour has been developed. The effects of apnea, hypo- and hyperventilation as well as those of inhalation of pure oxygen, and CO2 upon the perilymphatic Po2 have been measured by placing the electrode in the perilymph through the fenestrated stapedial footplate of 87 adult cats. The correlation between the arterial Pco2 and the perilymphatic Po2 is so close that even hypo- or hyperventilation in presence of air does influence the oxygen content of the perilymphatic space. In view of the effect of the smallest accumulation of alveolar CO2, particular attention has to be paid to the system used for respiration of the experimental animal, when determining the action of drugs or inhaled gas mixtures on the oxygenation of the inner ear fluids. The measurement of the perilymphatic oxygen tension also indicates that the rate of blood flow cannot be used to deduct with accuracy the actual degree of oxygenation of the inner ear fluids.

scholarly journals Oxygen Tension of Tissues by the Polarographic Method

Circulation ◽  
1951 ◽  
Vol 4 (1) ◽  
pp. 111-115 ◽  
Author(s):  
ORVILLE HORWITZ ◽  
GEORGE PEIRCE ◽  
HUGH MONTGOMERY
Keyword(s):  
Oxygen Tension ◽  
Polarographic Method
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