4. Sudden Cardiac Ischaemic Death Associated with Systemic Lupus Erythematosus

1994 ◽  
Vol 34 (1) ◽  
pp. 80-82 ◽  
Author(s):  
M A Elfawal
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Sudden Death ◽  
Coronary Disease ◽  
Lupus Erythematosus ◽  
Cardiac Death ◽  
Coronary Atherosclerosis ◽  
Medical Literature ◽  
Young Patients ◽  
Terminal Event ◽  
Systemic Lupus

Association between systemic lupus erythematosus and coronary atherosclerosis has been reported only rarely in the medical literature. Sudden ischaemic cardiac death in such cases is an uncommon terminal event, particularly in young patients. The severity of coronary atherosclerosis in these cases may be similar to those seen in the classic coronary disease. A case of a 22-year-old female systemic lupus patient is presented in whom sudden death was found at autopsy to be due to extensive coronary atherosclerosis.

scholarly journals Sudden Death in a 55-Year-Old Woman With Systemic Lupus Erythematosus

Circulation ◽  
1998 ◽  
Vol 98 (3) ◽  
pp. 271-275 ◽  
Author(s):  
Michael H. Kim ◽  
Gerald D. Abrams ◽  
Perry G. Pernicano ◽  
Kim A. Eagle
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Sudden Death ◽  
Lupus Erythematosus ◽  
Systemic Lupus

scholarly journals Chorea as a First Manifestation in Young Patients with Systemic Lupus Erythematosus who Was Initially Diagnosed with Rheumatic Fever

2012 ◽  
Vol 5 ◽  
pp. CCRep.S9143 ◽  
Author(s):  
Jamal A Albishri
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Rheumatic Fever ◽  
Lupus Erythematosus ◽  
Young Patients ◽  
Systemic Lupus ◽  
Incorrect Diagnosis ◽  
Rare Manifestation ◽  
Specific Increase ◽  
Anti Phospholipid Syndrome

Chorea is a rare manifestation of systemic lupus erythematosus (SLE). We report on a young patient with chorea who was diagnosed initially with rheumatic fever. Follow up and further evaluation confirmed the diagnosis of SLE and anti-phospholipid syndrome. Of special interest were the negative antiphospholipid (aPL) antibodies and the initial diagnosis of rheumatic fever which is still not uncommon problem in our region. The rarity of such presentation with joint and non specific increase of antistreptolysin O (ASO) titer might be the factors that led to an incorrect diagnosis. Early diagnosis and treatment of SLE and anti-phospholipid syndrome are very crucial and should be considered with such presentation.

CORONARY ATHEROSCLEROSIS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS AT AUTOPSY

2008 ◽  
Vol 37 (1) ◽  
pp. 1-9
Author(s):  
Sumio Fukumoto ◽  
Toshiro Tsemiarid ◽  
Mitsuru Kinjo ◽  
Kenzo Tanaka
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Coronary Atherosclerosis ◽  
Systemic Lupus

scholarly journals Premature Aortic Atherosclerosis in Systemic Lupus Erythematosus: A Controlled Transesophageal Echocardiographic Study

2009 ◽  
Vol 37 (1) ◽  
pp. 71-78 ◽  
Author(s):  
CARLOS A. ROLDAN ◽  
JOSEPH JOSON ◽  
JANEEN SHARRAR ◽  
CLIFFORD R. QUALLS ◽  
WILMER L. SIBBITT
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Independent Predictor ◽  
Young Patients ◽  
Intima Media Thickness ◽  
Age At Diagnosis ◽  
Aortic Atherosclerosis ◽  
Systemic Lupus ◽  
Cyclophosphamide Therapy ◽  
Echocardiographic Study

Objective.Premature carotid and coronary atherosclerosis are common in systemic lupus erythematosus (SLE), but data on aortic atherosclerosis (AA) are limited. Thus, using multiplane transesophageal echocardiography (TEE), we sought to determine the prevalence and clinical correlates of AA in patients with SLE.Methods.Forty-seven patients with SLE (44 women, age 38 ± 12 years) and 21 healthy controls (19 women, age 34 ± 12 years) underwent clinical and laboratory evaluations and TEE to assess AA defined as aortic intima media thickness (IMT) > 0.86 mm or plaques as > 50% focal IMT as compared with surrounding walls. TEE studies were interpreted by an experienced observer unaware of subjects’ clinical data.Results.The prevalence of abnormal aortic IMT, plaques, or both lesions was higher in patients as compared to controls (37%, 23%, and 43% vs 14%, 0%, and 14%, respectively, all p ≤ 0.02). In patients, age at diagnosis of SLE was the only positive independent predictor of AA [OR 1.12 per year from diagnosis of SLE, 95% confidence interval (CI) 1.04–1.19, p = 0.001] and cyclophosphamide therapy was the only negative independent predictor of AA (OR 0.186, 95% CI 0.153–0.95, p = 0.04, equivalent to 5.4 times less likely to develop AA).Conclusion.AA is common in young patients with SLE and is predicted by a later age at diagnosis of SLE, but is negatively correlated with cyclophosphamide therapy. Thus, early diagnosis and more aggressive immunosuppressive therapy may be required to decrease the development and progression of atherosclerosis in patients with SLE.

scholarly journals Altered coronary vasomotor function in young patients with systemic lupus erythematosus

2007 ◽  
Vol 56 (6) ◽  
pp. 1904-1909 ◽  
Author(s):  
Kumiko Hirata ◽  
Amudha Kadirvelu ◽  
Mitsuyo Kinjo ◽  
Robert Sciacca ◽  
Kenichi Sugioka ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Young Patients ◽  
Systemic Lupus ◽  
Vasomotor Function ◽  
Coronary Vasomotor Function

scholarly journals Isolated Tricuspid Valve Libman-Sacks Endocarditis in Systemic Lupus Erythematosus with Secondary Antiphospholipid Syndrome

2017 ◽  
Vol 44 (2) ◽  
pp. 147-149 ◽  
Author(s):  
Daniel Unic ◽  
Mislav Planinc ◽  
Davor Baric ◽  
Igor Rudez ◽  
Robert Blazekovic ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Mitral Valve ◽  
Tricuspid Valve ◽  
Antiphospholipid Syndrome ◽  
Tricuspid Regurgitation ◽  
Lupus Erythematosus ◽  
Rare Case ◽  
Medical Literature ◽  
Valvular Disease ◽  
Systemic Lupus

Libman-Sacks endocarditis, one of the most prevalent cardiac presentations of systemic lupus erythematosus, typically affects the aortic or mitral valve; tricuspid valve involvement is highly unusual. Secondary antiphospholipid syndrome increases the frequency and severity of cardiac valvular disease in systemic lupus erythematosus. We present the case of a 47-year-old woman with lupus and antiphospholipid syndrome whose massive tricuspid regurgitation was caused by Libman-Sacks endocarditis isolated to the tricuspid valve. In addition, we discuss this rare case in the context of the relevant medical literature.

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