scholarly journals Primary Hyperparathyroidism Secondary to Simultaneous Bilateral Parathyroid Carcinoma

2002 ◽  
Vol 81 (6) ◽  
pp. 395-401 ◽  
Author(s):  
Jimmy J. Brown ◽  
Hezla Mohamed ◽  
Lorraine Williams-Smith ◽  
Ryan Osborne ◽  
Joan Coker ◽  
...  
Keyword(s):  
Primary Hyperparathyroidism ◽  
Surgical Procedures ◽  
Parathyroid Carcinoma ◽  
Frozen Section ◽  
Rare Entity ◽  
Time Of Surgery ◽  
Frozen Section Diagnosis ◽  
Rare Malignancy ◽  
High Index Of Suspicion

Parathyroid carcinoma is a rare malignancy, and experience with its management is limited. It is generally accepted that surgery is the treatment of choice, and the initial operative intervention might represent the only chance for long-term success. At the time of surgery, a high index of suspicion for carcinoma is vital to performing the appropriate surgical procedures, because frozen-section diagnosis of parathyroid carcinoma is notoriously unreliable. In this article, we describe our experience with this rare entity.

Contemporary Evaluation and Management of Parathyroid Carcinoma

2020 ◽  
pp. JOP.19.00540
Author(s):  
Abbey L. Fingeret
Keyword(s):  
Primary Hyperparathyroidism ◽  
Parathyroid Carcinoma ◽  
Recurrent Disease ◽  
Tumor Burden ◽  
External Beam Radiation ◽  
Beam Radiation ◽  
Female Predominance ◽  
Males And Females ◽  
Rare Malignancy ◽  
Disease Free

Parathyroid carcinoma is a rare malignancy, representing 0.005% of all cancers and 0.5%-1% of all parathyroid disorders. Parathyroid carcinoma occurs equally in males and females, as opposed to primary hyperparathyroidism, which has a female predominance. Patients with parathyroid carcinoma present with symptoms of hypercalcemia, similar to those with benign primary hyperparathyroidism. Parathyroid carcinoma should be suspected when calcium or parathyroid hormone levels are high. Because of the difficulty of discerning parathyroid carcinoma from adenoma preoperatively, the diagnosis of carcinoma is often made only after parathyroidectomy. The goals of surgery are resection with negative margins because surgery represents the only opportunity for cure. Adjuvant therapy with chemotherapy or external beam radiation has not been proven to affect disease-free or overall survival for these patients. Recurrence is common, with reoperation recommended for resectable recurrent disease. Palliation with calcimimetic pharmacotherapy can aid with management of symptomatic hypercalcemia in recurrent or persistent disease after parathyroidectomy. Ultimately, patients succumb to sequelae of hypercalcemia rather than tumor burden.

scholarly journals Nonfunctional Metastatic Parathyroid Carcinoma in the Setting of Multiple Endocrine Neoplasia Type 2A Syndrome

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
María Posada-González ◽  
Joaquín Gómez-Ramírez ◽  
Manuel Luque-Ramírez ◽  
Mercedes Guijarro ◽  
Elena Martín-Pérez ◽  
...  
Keyword(s):  
Primary Hyperparathyroidism ◽  
Parathyroid Carcinoma ◽  
Multiple Endocrine Neoplasia ◽  
Multiple Endocrine Neoplasia Type ◽  
Medullary Thyroid ◽  
Endocrine Neoplasia ◽  
Endocrine Neoplasia Type ◽  
Rare Malignancy ◽  
Men 2A

Parathyroid carcinoma is a very rare malignancy. It has been associated with hyperparathyroidism-jaw tumour syndrome, familial isolated primary hyperparathyroidism, and multiple endocrine neoplasia type 1 (MEN-1) and 2A (MEN-2A) syndromes. We report a 54-year-old man with a MEN-2A which presents with a nonfunctional metastatic parathyroid carcinoma and a pheochromocytoma in the absence of medullary thyroid carcinoma. Only a few cases of parathyroid carcinoma have been reported in the literature associated with this syndrome.

scholarly journals Primary angiosarcoma of the larynx: a rare entity

2012 ◽  
Vol 94 (4) ◽  
pp. e146-e148 ◽  
Author(s):  
R Katna ◽  
A Deshmukh ◽  
E Sridhar ◽  
D Chaukar ◽  
A D’Cruz
Keyword(s):  
Total Laryngectomy ◽  
Frozen Section ◽  
Rare Entity ◽  
Neck Swelling ◽  
Malignant Tumours ◽  
Primary Angiosarcoma ◽  
Poorly Differentiated Carcinoma ◽  
Carcinoma Of The Larynx ◽  
Frozen Section Diagnosis ◽  
Poorly Differentiated

Angiosarcomas are extremely rare malignant tumours of the larynx. We present a case of laryngeal angiosarcoma in a 58-yearold man who presented with hoarseness of voice, dysphagia and neck swelling. The patient underwent a total laryngectomy with a pre-operative and frozen section diagnosis of a poorly differentiated carcinoma of the larynx. Histopathological and immunohistochemical evaluation revealed features of a laryngeal angiosarcoma. The case is presented for its rarity and diagnostic difficulty.

scholarly journals Non-functioning oxyphilic parathyroid carcinoma: a case report

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Masaomi Sen ◽  
Ryuta Nagaoka ◽  
Hiroko Kazusaka ◽  
Mami Matsui ◽  
Marie Saitou ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Parathyroid Carcinoma ◽  
Parathyroid Tissue ◽  
Thyroid Peroxidase ◽  
Endocrine Tumors ◽  
Thyroid Lobe ◽  
Normal Ranges ◽  
Rare Malignancy ◽  
Left Thyroid Lobe

Abstract Background Non-functioning parathyroid carcinoma is an extremely rare malignancy among endocrine tumors. We report a case in which non-functional oxyphilic parathyroid carcinoma was diagnosed from clinical symptoms and pathological diagnosis. Case presentation The patient was a 42-year-old man with no medical or family history of note. He had presented to a local hospital with a neck mass 2 months earlier. Medullary thyroid carcinoma was diagnosed and he was referred to our department. A 3.5-cm mass was observed in the left thyroid lobe. Laboratory data for thyroid functions, thyroglobulin, anti-thyroglobulin antibodies, anti-thyroid peroxidase antibodies, serum calcium, and parathyroid hormone (PTH) were all within normal ranges. Ultrasonography revealed a 40-mm irregular, hypoechoic mass throughout the left thyroid lobe. Follicular thyroid tumor was suspected from fine-needle aspiration cytology. Left lobectomy was performed. Pathological features revealed a thick fibrous capsule around the tumor, and a thick fibrous band was observed inside the tumor. Both capsular invasions and vascular invasions were observed. Tumor cells were eosinophilic and displayed solid growth. Immunohistochemically, tumor cells were negative for thyroid transcription factor-1, negative for thyroglobulin, negative for chromogranin A (positive for normal parathyroid tissue within the nodule), positive for PTH, and positive for parafibromin. Ki-67 labeling index was 10%. Based on these findings, non-functional oxyphilic parathyroid carcinoma was diagnosed. One and a half years postoperatively, calcium and PTH were within normal ranges, and he has shown no evidence of recurrence or metastasis. Conclusions Non-functioning oxyphilic parathyroid carcinoma is an extremely rare malignancy, and definitive diagnosis is difficult to obtain preoperatively. Few reports have been made worldwide, and information on the long-term prognosis is scarce. Long-term surveillance by imaging is mandatory, since no indices that can be used as a marker for postoperative recurrence and metastasis have been identified.

scholarly journals Solid Pseudopapillary Tumor of Pancreas: A Case Report

2013 ◽  
Vol 3 (1) ◽  
pp. 54-58
Author(s):  
Md. Mamunur Rashid ◽  
Hashim Rabbi ◽  
Azharul Islam ◽  
Muhd. Mustaque Hussain ◽  
Md. Mohsin Kabir ◽  
...  
Keyword(s):  
Frozen Section ◽  
Radical Resection ◽  
Young Female ◽  
Malignant Potential ◽  
Pancreatic Tumors ◽  
Solid Pseudopapillary Tumor ◽  
Term Survival ◽  
High Index Of Suspicion ◽  
Quality Imaging

Solid pseudopapillary tumor of pancreas is a rare tumor almost exclusively affecting the young female and accounts for <1% of all pancreatic tumors. Most hypothesis suggests that the tumor arises from embryonic pleuripotent stem cells. Although mostly benign in nature, the tumor may show malignant potentials and the patient may present with hepatic, omental or other meatstasis. High index of suspicion is the key for early dianosis. Good quality imaging (USG and CT scan) & FNAC are necessary for proper evaluation of the lesion. Peroperative frozen section biopsy may be necessary to ascertain its malignant potential. Radical resection is the best modality of treatment for achieving curative results and a better long-term survival. We are reporting our experience of treating a case of solid pseudopapillary tumor of pancreas in BIRDEM Hospital. Birdem Med J 2013; 3(1): 54-58 DOI: http://dx.doi.org/10.3329/birdem.v3i1.17129

A RARE CASE OF MAXILLARY BROWN TUMOUR AS PRIMARY PRESENTATION OF THE PARATHYROID CARCINOMA.

2021 ◽  
pp. 63-65
Author(s):  
Fehmida M Laxmidhar ◽  
Bhavin P. Vadodariya ◽  
Sanjiv Shah ◽  
Murtuza I Laxmidhar
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Primary Hyperparathyroidism ◽  
Parathyroid Carcinoma ◽  
Frozen Section ◽  
Elevated Serum ◽  
Brown Tumor ◽  
Facial Bones ◽  
Elderly Male ◽  
Brown Tumors

Background: Brown tumours are expansile osteolytic lesions of bone, occurring in Hyperparathyroidism. Brown tumours occur most commonly in ribs, clavicle, long bones and pelvis and are uncommon in other facial bones except mandible. Other facial bones are rarely affected. Brown tumors are due to the direct effect of the parathyroid hormone. Brown tumors occur more with primary hyperparathyroidism than secondary. However, they are reported more in secondary hyperparathyroidism. In primary hyperparathyroidism, a parathyroid adenoma is a cause in 81% while other causes include hyperplasia in 15% and parathyroid carcinoma only in 4%. We present a case report of maxillary Brown tumor due to parathyroid carcinoma in an elderly male patient. Case Report: A 67-year-old male presented with right maxillary swelling increasing in size for the last few months associated with ipsilateral nasal block and right eye epiphora. The contrast CT scan of paranasal sinuses and neck revealed a large expansile right maxillary tumor aggressively eroding maxillary wall with extension into the orbital oor, ethmoid, sphenoid sinuses, nasal cavity, and oral cavity with the erosion of hard palate and soft tissue extension to subcutaneous Plane. A three cm sized soft tissue density lesion was also noted posterior to the right thyroid lobe in CT sections of the neck. Blood prole was normal except extremely high serum parathormone and calcium as well as mildly elevated serum creatinine (S. PTH 3437 pg./ml. S. Ca. 19 mg%. S. Creatinine 1.77mg%.) Ultrasonography of the abdomen also revealed calcication in the renal medulla. Right lower parathyroidectomy was done with the frozen section as well as the Intraoperative Rapid PTH assay. The PTH level was reduced by 90 percent of the original value. The nal histopathology was suggestive of parathyroid carcinoma. Summary: The patient was under regular surveillance, as the maxillary tumor was under remittance after the resection of parathyroid carcinoma. Parathyroid carcinoma is a very rare tumor and involvement of maxillary bone due to primary hyperparathyroidism due to parathyroid carcinoma is also uncommon.

The rare cause of primary hyperparathyroidism: Parathyroid Carcinoma

2017 ◽  
Author(s):  
Nagihan Bestepe ◽  
Didem Ozdemir ◽  
Sefika Burcak Polat ◽  
Berna Evranos ◽  
Reyhan Ersoy ◽  
...  
Keyword(s):  
Primary Hyperparathyroidism ◽  
Parathyroid Carcinoma

scholarly journals Systematic Review of the Use of Telepathology During Intraoperative Consultation

2019 ◽  
Vol 153 (2) ◽  
pp. 198-209 ◽  
Author(s):  
Robin L Dietz ◽  
Douglas J Hartman ◽  
Liron Pantanowitz
Keyword(s):  
Systematic Review ◽  
Publication Bias ◽  
Frozen Section ◽  
Strong Support ◽  
Risk Of Bias ◽  
Low Risk ◽  
Reference Standard ◽  
Weighted Mean ◽  
Frozen Section Diagnosis ◽  
Conventional Microscopy

Abstract Objective To compare studies that used telepathology systems vs conventional microscopy for intraoperative consultation (frozen-section) diagnosis. Methods A total of 56 telepathology studies with 13,996 cases in aggregate were identified through database searches. Results The concordance of telepathology with the reference standard was generally excellent, with a weighted mean of 96.9%. In comparison, we identified seven studies using conventional intraoperative consultation that showed a weighted mean concordance of 98.3%. Evaluation of the risk of bias showed that most of these studies were low risk. Conclusions Despite limitations such as variation in reporting and publication bias, this systematic review provides strong support for the safety of using telepathology for intraoperative consultations.

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