scholarly journals Acrokeratosis Paraneoplastica (Bazex Syndrome)

2017 ◽  
Vol 96 (10-11) ◽  
pp. 413-414 ◽  
Author(s):  
Jérôme R. Lechien ◽  
Mohamad Khalife ◽  
Sven Saussez
Keyword(s):  
Acrokeratosis Paraneoplastica Bazex

scholarly journals A Review of Nail Changes in Acrokeratosis Paraneoplastica (Bazex Syndrome)

2021 ◽  
pp. 1-10
Author(s):  
Bipasha Roy ◽  
Shari R. Lipner
Keyword(s):  
Head And Neck ◽  
Squamous Cell ◽  
Clinical Presentation ◽  
Nail Plate ◽  
Squamous Cell Carcinomas ◽  
Morbidity And Mortality ◽  
Cutaneous Manifestations ◽  
Nail Changes ◽  
Paraneoplastic Dermatosis ◽  
Acrokeratosis Paraneoplastica Bazex

Acrokeratosis paraneoplastica (Bazex syndrome) is a rare paraneoplastic dermatosis associated with internal malignancies. Clinical presentation is characterized by erythematous or violaceous scaly plaques involving the digits, nose, ears, palms, and soles. Nail changes commonly present concurrently with cutaneous manifestations. In this review, we characterize nail changes associated with acrokeratosis paraneoplastica. A total of 48 cases were analyzed. Nail findings were nonspecific, with the most common being nail plate thickening, onycholysis, subungual hyperkeratosis, longitudinal ridging, discoloration, and nail plate loss. In most patients, nail changes involved the majority of fingernails and toenails and most often appeared prior to the diagnosis of malignancy. The most common associated underlying malignancies were squamous cell carcinomas of the head and neck. A diagnosis of acrokeratosis paraneoplastica should be considered in patients with onychodystrophy involving multiple nails with accompanying atypical psoriasiform dermatoses. Screening for internal malignancies may significantly decrease morbidity and mortality for these patients.

scholarly journals Acrokeratosis paraneoplastica (Bazex syndrome) associated with peripheral T-cell lymphoma

2019 ◽  
Vol 5 (1) ◽  
pp. 86-88 ◽  
Author(s):  
Trissa M. McClatchey ◽  
Dylan Haynes ◽  
Veselina B. Korcheva ◽  
Jesse Keller
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Peripheral T Cell Lymphoma ◽  
Acrokeratosis Paraneoplastica Bazex

Acrokeratosis Paraneoplastica (Bazex’ Syndrome) Associated With Metastatic Squamous Cell Esophageal Carcinoma

2008 ◽  
Vol 26 (31) ◽  
pp. 5128-5129 ◽  
Author(s):  
Guillaume Louvel ◽  
Elodie Vauléon ◽  
Eveline Boucher ◽  
Jean-Luc Raoul
Keyword(s):  
Esophageal Carcinoma ◽  
Squamous Cell ◽  
Acrokeratosis Paraneoplastica Bazex

scholarly journals Acrokeratosis paraneoplastica Bazex syndrome associated with esophageal squamocellular carcinoma

2008 ◽  
Vol 65 (6) ◽  
pp. 485-487 ◽  
Author(s):  
Ljiljana Medenica ◽  
Mirjana Gajic-Veljic ◽  
Dusan Skiljevic ◽  
Predrag Pesko
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cervical Lymphadenopathy ◽  
Skin Lesions ◽  
Specific Marker ◽  
Upper Aerodigestive Tract ◽  
Skin Changes ◽  
Underlying Malignancy ◽  
Acrokeratosis Paraneoplastica Bazex

Background. Acrokeratosis paraneoplastica Bazex (APB) is a very rare disease in the group of obligate paraneoplastic dermatoses, associated mostly with squamous cell carcinoma of the upper aerodigestive tract and metastatic cervical lymphadenopathy. The disease is characterized by violaceous erythemosquamous changes on the acral regions. This entity was first reported by Bazex in 1965. About 160 cases have been presented so far. Case report. We presented a patient with a three-month history of violaceous erythema, edema, erosions and scaling on the acral regions, elbows and knees and severe nail dystrophy. When the diagnosis was established, he did not have any symptom of internal malignancy. Esophagogastroscopy revealed ulcerovegetant lesion of the esophagus, while histology showed squamocellular invasive carcinoma. Surgical tumor removal resulted in significant improvement of skin changes in 15 days. Unfortunately, four months later, extensive skin lesions pointed to metastasis of squamous cell carcinoma. Conclusion. Skin changes can precede a few years the first manifestations of neoplasia. The course of the disease in our patient proved that APB is a specific marker of underlying malignancy.

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