scholarly journals Prediction of Malignancy in Salivary Gland Tumors by a New Cytology Reporting System

2020 ◽  
pp. 014556132092791
Author(s):  
Doh Young Lee ◽  
Seulki Song ◽  
Seung Koo Yang ◽  
Min Hyung Lee ◽  
Ji Eun Kim ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Cell Carcinoma ◽  
Malignant Tumor ◽  
Fine Needle Aspiration ◽  
Final Diagnosis ◽  
Needle Aspiration ◽  
Salivary Gland Tumors ◽  
Fine Needle ◽  
Risk Of Malignancy ◽  
Undetermined Significance

Objectives: The aim of this study was to analyze the risk of malignancy in salivary gland tumors on the basis of the Milan System for Reporting Salivary Gland Cytopathology. Methods: A retrospective review was performed of the charts of patients with salivary gland tumors in whom the final diagnosis was confirmed by surgical excision. Preoperative fine needle aspiration results were categorized according to the Milan System for Reporting Salivary Gland Cytopathology: non-diagnostic (category I), nonneoplastic (category II), atypia of undetermined significance (category III), neoplasm (category IV), suspicious for malignancy (category V), and malignant (category VI). Fine needle aspiration and final diagnosis were compared, and the risk of malignancy and operative/oncological outcomes were analyzed. Results: A total of 288 patients were enrolled in this study. Postoperative histopathologic salivary gland malignancies were found in 30 (10.4%) patients. Risk of malignancy was 7.1%, 0%, 48.0%, 4.8%, 88.7%, and 100% in categories I, II, III, IV, V, and VI, respectively. The most common malignant tumor in category III was salivary duct carcinoma (37.5%), followed by acinic cell carcinoma (25.0%), mucoepidermoid carcinoma (25.0%), and squamous cell carcinoma (12.5%). The 5-year survival rate of patients with malignant tumors showed no statistical difference between category III and category V/VI ( P = .140). Risk of malignancy was 88.9% and 100% in category V and VI, respectively. Conclusions: A half of atypia of undetermined significance (category III) cases were malignant. Once diagnosed, the prognosis of malignant tumor in category III was similar with that in category V/VI.

Risk of malignancy in “atypia of undetermined significance” category of salivary gland fine‐needle aspiration: A bi‐institutional experience

2019 ◽  
Vol 48 (2) ◽  
pp. 138-143 ◽  
Author(s):  
Fatimah Alruwaii ◽  
Jen‐Fan Hang ◽  
Bao‐Rung Zeng ◽  
Harvey M. Cramer ◽  
Chiung‐Ru Lai ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Fine Needle ◽  
Risk Of Malignancy ◽  
Institutional Experience ◽  
Undetermined Significance

scholarly journals Is DOG1 really useful in the diagnosis of salivary gland acinic cell carcinoma? - A DOG1 (clone K9) analysis in fine needle aspiration cell blocks and the review of the literature

CytoJournal ◽  
2015 ◽  
Vol 12 ◽  
pp. 18 ◽  
Author(s):  
Sule Canberk ◽  
Mine Onenerk ◽  
Elif Sayman ◽  
Ceren Canbey Goret ◽  
Murat Erkan ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Cell Carcinoma ◽  
Tumor Cells ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Salivary Gland Tumors ◽  
Acinic Cell Carcinoma ◽  
Review Of The Literature ◽  
Fine Needle ◽  
Acinic Cell

Introduction: DOG1 is a transmembrane protein originally “discovered on gastrointestinal stromal tumors,” works as a calcium-activated chloride channel protein. There is a limited number of studies on the potential usage of this antibody in the diagnosis of salivary gland tumors on routine practice in cell blocks. The aim of this study was to search for the usefulness of K9 clone in oncocytic type tumors and review of the literature. Materials and Methods: Sixty-nine fine needle aspiration (FNA) cytologic materials of predominantly oncocytic morphology salivary gland tumors; acinic cell carcinoma (AciCC) (n = 8), adenoid cystic carcinoma (n = 2), pleomorphic adenoma (PA) (n = 22), Warthin tumor (WT) (n = 20), myoepithelioma (ME) (n = 5), benign oncocytoma (BeO) (n = 3), mucoepidermoid carcinoma (MEC) (n = 7), mammary analog salivary gland carcinoma (n = 2) were immunostained with DOG1 (clone K9) stain. Results: Of the 8 AciCCs, 7 were observed apical-luminal positive staining, demonstrating 1–3 + intensity, and involving 40–70% of the tumor cells. One MEC of 7 (14%), 1 ME of 5 (20%), and 4 PA of 22 (18%) showed weak (1+) cytoplasmic granular staining in 5–10% of the tumor cells. Pure oncocytic neoplasms (WT, BeO) showed no expression with DOG1-K9. Conclusions: FNA is a common tool in the diagnosis and management of salivary gland tumors. DOG1-K9 clone was very useful with a unique staining pattern of apical-luminal positivity in the differential diagnosis of AciCC from other oncocytic salivary gland tumors.

“Atypical” salivary gland fine needle aspiration: Risk of malignancy and interinstitutional variability

2017 ◽  
Vol 45 (12) ◽  
pp. 1088-1094 ◽  
Author(s):  
He Wang ◽  
Aatika Malik ◽  
Zahra Maleki ◽  
Esther Diana Rossi ◽  
Bo Ping ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Fine Needle ◽  
Aspiration Risk ◽  
Risk Of Malignancy

scholarly journals Clinical analysis of fine-needle aspiration (FNA) in thyroid and salivary gland tumors

2016 ◽  
Vol 25 (3) ◽  
pp. 403-408
Author(s):  
Norihiko Narita ◽  
Takahiro Tokunaga ◽  
Masahumi Kanno ◽  
Dai Susuki ◽  
Tetsuji Takabayashi ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Clinical Analysis ◽  
Salivary Gland Tumors ◽  
Fine Needle

scholarly journals Surgical Outcome of Thyroid Nodules with Atypia of Undetermined Significance and Follicular Lesion of Undetermined Significance in Fine Needle Aspiration Biopsy

2017 ◽  
Vol 9 (3) ◽  
pp. 100-103
Author(s):  
Saad Alqahtani ◽  
Saif Alsobhi ◽  
Riyadh I Alsalloum ◽  
Saleh N Najjar ◽  
Hindi N Al-Hindi
Keyword(s):  
Fine Needle Aspiration ◽  
Surgical Outcome ◽  
Thyroid Nodules ◽  
Fine Needle Aspiration Biopsy ◽  
Needle Aspiration ◽  
Aspiration Biopsy ◽  
Fine Needle ◽  
Risk Of Malignancy ◽  
Needle Aspiration Biopsy ◽  
Undetermined Significance

ABSTRACT Aim To correlate selected clinical and ultrasonographic (US) characteristics with the final histopathological diagnosis in patients with atypia of undetermined significance (AUS) and follicular lesion of undetermined significance (FLUS), and whether this information can be used in planning the surgical approach. Materials and methods It is a retrospective study including the operated cases of AUS/FLUS from 2011 to 2014 treated at one center. Results This cohort included 87 women and 28 men. To test for independence between categorical variables, the chi-square test was used. There was no significant correlation between age or US variables and final pathological diagnosis. However, final diagnosis of malignancy was higher in men compared with women (64.3 and 41.4% respectively; p = 0.035). Furthermore, a significant association between the diagnosis of repeated fine needle aspiration biopsy (FNAB) and the final pathological diagnosis was noted (benign vs malignant, p = 0.005). Conclusion The FNAB has a significant role in the assessment of thyroid nodules. Our results showed no correlation between age, US variables, and the risk of malignancy. Male gender is associated with higher risk of malignancy. Clinical significance Determining the risk of malignancy and prediction of surgical outcome may help triaging cases for repeat FNA or proceeding to surgery. How to cite this article Alqahtani S, Alsobhi S, Alsalloum RI, Najjar SN, Al-Hindi HN. Surgical Outcome of Thyroid Nodules with Atypia of Undetermined Significance and Follicular Lesion of Undetermined Significance in Fine Needle Aspiration Biopsy. World J Endoc Surg 2017;9(3):100-103.

Fine-needle aspiration with selective use of core needle biopsy of major salivary gland tumors

2017 ◽  
Vol 127 (11) ◽  
pp. 2522-2527 ◽  
Author(s):  
Erica B. Romano ◽  
Jason M. Wagner ◽  
Anthony M. Alleman ◽  
Lichao Zhao ◽  
Rachel D. Conrad ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Fine Needle Aspiration ◽  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Needle Aspiration ◽  
Salivary Gland Tumors ◽  
Major Salivary Gland ◽  
Core Needle ◽  
Fine Needle

Is fine-needle aspiration a reliable tool in the diagnosis of malignant salivary gland tumors?

2017 ◽  
Vol 45 (7) ◽  
pp. 1074-1077 ◽  
Author(s):  
Francisco Ramírez-Pérez ◽  
Raúl González-García ◽  
Cristina Hernández-Vila ◽  
Florencio Monje-Gil ◽  
Luis Ruiz-Laza
Keyword(s):  
Salivary Gland ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Salivary Gland Tumors ◽  
Fine Needle ◽  
Reliable Tool ◽  
Malignant Salivary Gland Tumors

scholarly journals Moving Toward a Systematic Approach for Reporting Salivary Gland Cytopathology: An Institutional Experience and Literature Review

2018 ◽  
Vol 143 (6) ◽  
pp. 664-669 ◽  
Author(s):  
Xunda Luo ◽  
Nirag Jhala ◽  
Jasvir S. Khurana ◽  
Christopher Fundakowski ◽  
Darshana N. Jhala ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Fine Needle Aspiration ◽  
Predictive Value ◽  
Reporting System ◽  
Collaborative Work ◽  
Benign Neoplasm ◽  
Needle Aspiration ◽  
Fine Needle ◽  
Tier System ◽  
Risk Of Malignancy

Context.— Despite the clinical utility of fine-needle aspiration for the diagnosis of salivary pathologies, salivary lesions remain one of the most challenging areas in cytopathology. This is partially because there is no consensus on how to report salivary gland cytopathology, which has resulted in inconsistent terminology among institutions and individual cytopathologists and in confusion in communication among cytopathologists and ordering providers. Objective.— To summarize our experience with an institutional salivary gland cytopathology reporting system, as an initiative to promote collaborative work toward a consensus on a reporting system. Design.— We developed an empirical 6-tier classification reporting system. Slides of 107 salivary gland fine-needle aspirations with subsequent histology slides were reviewed and reclassified using the 6-tier system. The performance of the cytology reporting system was evaluated with the histology diagnoses serving as the gold standard. Results.— Fine-needle aspiration diagnoses made based on the institutional 6-tier classification system were generally consistent with histology diagnoses for the disease spectrum reported in this study. The sensitivity, specificity, positive predictive value, and negative predictive value for diagnosing malignancies with the system were 86% (12 of 14), 93% (40 of 43), 80% (12 of 15), and 95% (40 of 42), respectively. The risk of malignancy increased from 0% (0 of 13) for negative for neoplasm to 7% (2 of 29) for benign neoplasm, 67% (2 of 3) for suspicious for malignancy, and 83% (10 of 12) for positive for malignancy. Conclusions.— The institutional 6-tier system provides a succinct, risk-of-malignancy–based system to report salivary gland cytology. Our experience with this system helps to pave the way for the adoption of the Milan System for Reporting Salivary Gland Cytopathology.

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