Influence of argon laser stapedotomy on inner ear function and temperature

1983 ◽  
Vol 91 (5) ◽  
pp. 521-526 ◽  
Author(s):  
Michael Vollrath ◽  
Christoph Schreiner
Keyword(s):  
Action Potential ◽  
Inner Ear ◽  
Guinea Pigs ◽  
Time Course ◽  
Argon Laser ◽  
Compound Action Potential ◽  
Clinical Use ◽  
Cochlear Microphonics ◽  
Temperature Changes ◽  
Compound Action

The influence of argon laser stapedotomy on inner ear function was investigated in guinea pigs. The cochlear microphonics (CM) and the compound action potential (CAP) served as parameters for the functional status of the cochlear. Transitory depression of both potentials was found during and after laser stapedotomy. The time course of CM and CAP depression and recovery is compared to endocochlear temperature changes. Possible implications for clinical use are discussed.

Effects of Nimodipine on Quinine Ototoxicity

2003 ◽  
Vol 112 (2) ◽  
pp. 163-168 ◽  
Author(s):  
Kentaro Ochi ◽  
Hirotsugu Kinoshita ◽  
Hirohito Nishino ◽  
Mutsumi Kenmochi ◽  
Toru Ohashi
Keyword(s):  
Action Potential ◽  
Guinea Pigs ◽  
Round Window ◽  
Compound Action Potential ◽  
Simultaneous Administration ◽  
Quinine Hydrochloride ◽  
Click Train ◽  
Compound Action

The compound action potential (CAP) in response to a click train stimulus was recorded at the round window of guinea pigs. Administration of quinine hydrochloride (200 mg/kg) significantly elevated the CAP thresholds by 5 to 25 dB (p < .05), and the CAP waveform elicited by the click train stimulus was abnormal. The amplitude of the CAP elicited by the second click was bigger than that elicited by the first click. These changes may be caused by an abnormally broadened N1 response to the first click in the click train. In contrast, CAP waveforms elicited by the second and subsequent clicks appeared normal. After administration of nimodipine (2 mg/kg), the CAP thresholds and waveforms elicited by the click train stimulus were unchanged. Simultaneous administration of both quinine (200 mg/kg) and nimodipine (2 mg/kg) resulted in the same electrophysiological changes as those induced by quinine alone. These results suggest that nimodipine prevents neither the deterioration in the CAP nor the abnormal properties in the response to a click train stimulus.

scholarly journals Changes over time in the electrically evoked compound action potential (ECAP) interphase gap (IPG) effect following cochlear implantation in Guinea pigs

2019 ◽  
Vol 383 ◽  
pp. 107809 ◽  
Author(s):  
Kara C. Schvartz-Leyzac ◽  
Deborah J. Colesa ◽  
Christopher J. Buswinka ◽  
Donald L. Swiderski ◽  
Yehoash Raphael ◽  
...  
Keyword(s):  
Action Potential ◽  
Cochlear Implantation ◽  
Guinea Pigs ◽  
Compound Action Potential ◽  
Evoked Compound Action Potential ◽  
Changes Over Time ◽  
Over Time ◽  
Compound Action

scholarly journals Comparative Studies on Distortion Product Otoacoustic Emissions and Compound Action Potential in Cisplatin Treated Guinea Pigs.

1997 ◽  
Vol 40 (6) ◽  
pp. 719-723
Author(s):  
Narihisa Tachihara ◽  
Hideki Okubo ◽  
Shigenori Satoh ◽  
Kazuhiko Takahashi ◽  
Tetsurou Wada ◽  
...  
Keyword(s):  
Action Potential ◽  
Comparative Studies ◽  
Guinea Pigs ◽  
Otoacoustic Emissions ◽  
Compound Action Potential ◽  
Distortion Product Otoacoustic Emissions ◽  
Distortion Product ◽  
Compound Action
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