Single-Dose Treatment of Trichomonal Vaginitis: A Comparison of Tinidazole and Metronidazole

1973 ◽  
Vol 1 (2) ◽  
pp. 438-441
Author(s):  
R Anjaneyulu ◽  
S A Gupte ◽  
D B Desai
Keyword(s):  
Single Dose ◽  
Side Effects ◽  
Clinical Response ◽  
Clinical Improvement ◽  
Statistical Evaluation ◽  
Comparative Trial ◽  
Dose Treatment ◽  
Satisfactory Clinical Response ◽  
Single Dose Treatment ◽  
Better Than

A randomized, comparative trial was carried out in 100 patients with trichomonal vaginitis to compare the efficacy and toleration of a single 2 g dose of tinidazole and metronidazole. Tinidazole produced parasitological cure in 94% of patients (47/50) and a satisfactory clinical response in 96% of patients (48/50); for metronidazole the figures were 64% (32/50) and 72% (36/50) respectively. Side-effects were reported by 52% of patients (26/50) on tinidazole and 82% of patients (41/50) on metronidazole. Severity of side-effects and their frequency per patient were significantly less (p<0.05 to 0.01) with tinidazole than with metronidazole. Statistical evaluation of the results showed that tinidazole was significantly better than metronidazole with respect to parasitological cure (p<0.01) and clinical improvement (p<0.01) and also with regard to the incidence and intensity of side effects (p<0.01).

A Comparative Trial of Two Formulations of Clomipramine

1972 ◽  
Vol 1 (1) ◽  
pp. 30-36 ◽  
Author(s):  
G Beaumont ◽  
J Seldrup
Keyword(s):  
Clinical Trial ◽  
Side Effects ◽  
Clinical Response ◽  
Clinical Improvement ◽  
General Practitioners ◽  
Rating Scale ◽  
Drug Effects ◽  
Comparative Trial ◽  
Good Clinical Response ◽  
Clinical Rating Scale

In a multi-centre clinical trial comparing two formulations of Clomipramine (Anafranil® Geigy) thirty General Practitioners provided two hundred and seven patients. One hundred and forty nine patients completed the study. No difference was found between a capsule and a tablet formulation in terms of tolerance and efficacy. Using a clinical rating scale the total score for twelve symptoms fell from a mean of 18 .2 to 5.5 and 6.0 in the capsule and tablet groups respectively. By recording the presence of symptoms subsequently to be regarded as side effects before admission to the trial many so called drug effects were found to be present before commencing treatment. The forty patients who dropped out of the trial because of intolerable side effects also failed to show any clinical improvement and appeared to constitute a separate group from those who completed the trial and who showed good clinical response in association with a diminishing number of side effects.

Single-Dose Oral Treatment of Vaginal Trichomoniasis with Tinidazole and Metronidazole

1978 ◽  
Vol 6 (1) ◽  
pp. 46-49 ◽  
Author(s):  
H T Manorama Rao ◽  
D Radhakrishna Shenoy
Keyword(s):  
Single Dose ◽  
Side Effects ◽  
Clinical Response ◽  
Oral Treatment ◽  
Complete Relief ◽  
Treatment Groups ◽  
Dose Oral ◽  
Satisfactory Clinical Response ◽  
The One

Sixty cases of trichomonal vaginitis were randomly allocated to treatment with tinidazole or metronidazole, both administered as a 2 g single dose. One patient on tinidazole did not complete her follow-up. Parasitological cure was obtained in all patients in both the treatment groups. A satisfactory clinical response was obtained in all 29 patients on tinidazole, and in 27 out of 30 (90%) on metronidazole. Complete relief of symptoms was obtained in 62% (18/29) and 13% (4/30) of patients on tinidazole and metronidazole, respectively (p<0.01). Ten patients on tinidazole and 24 on metronidazole manifested side-effects. The frequency and severity of side-effects were much more in the metronidazole group (p <0.01). Tinidazole has distinct advantages over metronidazole in the one-dose treatment of trichomonal vaginitis.

scholarly journals Baloxavir Marboxil Single-dose Treatment in Influenza-infected Children

2020 ◽  
Vol 39 (8) ◽  
pp. 700-705 ◽  
Author(s):  
Jeffrey Baker ◽  
Stanley L. Block ◽  
Balpreet Matharu ◽  
Laura Burleigh Macutkiewicz ◽  
Steffen Wildum ◽  
...  
Keyword(s):  
Single Dose ◽  
Dose Treatment ◽  
Single Dose Treatment

Zuclopenthixol acetate(5% in ‘Viscoleo’): Single-dose treatment for acutely disturbed psychotic patients

1990 ◽  
Vol 12 (1) ◽  
pp. 58-65 ◽  
Author(s):  
S. K. Chakravarti ◽  
A. Muthu ◽  
P. K. Muthu ◽  
P. Naik ◽  
R. T. Pinto
Keyword(s):  
Single Dose ◽  
Dose Treatment ◽  
Single Dose Treatment

Single-dose Treatment of Uncomplicated Gonorrhea in Men with Intramuscular and Oral Thiamphenicol

1984 ◽  
Vol 11 ◽  
pp. 404-406
Author(s):  
KANCHANA PANIKABUTRA ◽  
CHARAS ARIYARIT ◽  
ANUPONG CHITWARAKORN ◽  
AMPORN SOONTHARARAK ◽  
CHOOSAK SAENSANOH
Keyword(s):  
Single Dose ◽  
Dose Treatment ◽  
Single Dose Treatment ◽  
Uncomplicated Gonorrhea
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