Changes in the Plasma Pattern of Sex Steroids in Patients with Liver Cirrhosis Treated with Mepartricin

1989 ◽  
Vol 17 (3) ◽  
pp. 212-217 ◽  
Author(s):  
A. Tavanti ◽  
M. Delle Monache ◽  
A. Ulissi ◽  
S. Del Vecchio ◽  
M.A. Rapocci ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Plasma Concentration ◽  
Sex Steroids ◽  
Medical Staff ◽  
Follicle Stimulating Hormone ◽  
The Other ◽  
Cirrhotic Patients ◽  
Stimulating Hormone

Mepartricin was given to cirrhotic patients in order to evaluate its effect on the imbalance of sex steroids which is typical of this disorder. Patients were divided into two groups: one group received placebo ( n=19) and the other received 150000 IU/day mepartricin for 30 days ( n=19). The patients were evaluated by separate medical staff who were unaware of the treatment. Mepartricin significantly decreased the plasma concentration of testosterone, oestradiol and prolactin as compared with the values at the start of the trial, while no significant changes were seen in the occurrence of gynaecomastia. No relevant changes were seen in patients receiving the control, except for a slight increase in the peripheral concentration of androstenedione, aldosterone and follicle stimulating hormone.

scholarly journals Low Serum 25-Hydroxy Vitamin D (25-OHD) and Hepatic Encephalopathy in HCV-Related Liver Cirrhosis

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Mohamed Abd Ellatif Afifi ◽  
Ahmed Mohamed Hussein ◽  
Mahmoud Rizk
Keyword(s):  
Vitamin D ◽  
Liver Cirrhosis ◽  
Liver Disease ◽  
Hepatic Encephalopathy ◽  
Wide Spectrum ◽  
The Other ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D ◽  
Cirrhotic Patients ◽  
Low Serum

Background. Patients with liver cirrhosis experience a large variety of metabolic disorders associated with more hepatic decompensation. Hepatic encephalopathy (HE) is a significant complication in liver cirrhosis patients, presenting a wide spectrum of neuropsychological symptoms. A deficiency of 25-hydroxy vitamin D (25-OHD) in the general population is associated with a loss of cognitive function, dementia, and Alzheimer’s disease. Aim of the Study. Our study aims to check the relationship between low serum 25-OHD and HE in patients with HCV-related liver cirrhosis and assess its link with patient mortality. Patients and Methods. This study was observationally carried out on 100 patients with HCV-related liver cirrhosis. The patients were divided into 2 groups: Group A—included 50 HCV-related cirrhotic patients with HE, and Group B—included 50 HCV-related cirrhotic patients without HE. Assessment of disease severity using the end-stage liver disease (MELD) model and Child Turcotte Pugh (CTP) scores were done, and 25-OHD levels were measured. Comparison of vitamin D levels in different etiologies and different CTP categories was made using one-way ANOVA. Pearson’s correlation between the level of vitamin D and other biomarkers was applied. Results. There was a statistically significant Vitamin D level difference between the two groups. A lower level of vitamin D was observed in the HE group where the severe deficiency was 16%, while it was 6% in the other group and the moderate deficiency was 24% in HE group as compared to 10% in the other group. The insufficient vitamin D level represented 46% of the non-HE group while none of the HE group falls in this category. Vitamin D level was statistically higher in Grade 1 HE than in Grade 2 which is higher than in Grades 3 to 4. Vitamin D level was also significantly higher in those who improved from HE as compared to those who died. Conclusion. The lower levels of 25-OHD were associated with the higher incidence of HE in cirrhotic HCV patients. The worsening vitamin D deficiency was associated with increased severity of the liver disease, so vitamin D may be considered a prognostic factor for the severity of liver cirrhosis and high mortality rate in HE patients.

Endocrine and local testicular regulation

2011 ◽  
pp. 1347-1353
Author(s):  
Ilpo Huhtaniemi
Keyword(s):  
Growth Factors ◽  
Luteinizing Hormone ◽  
Leydig Cell ◽  
Follicle Stimulating Hormone ◽  
Regulatory System ◽  
The Other ◽  
Seminiferous Tubules ◽  
Testicular Function ◽  
Cell Product ◽  
Stimulating Hormone

The testis has two functions, androgen production and spermatogenesis, and a key role in their regulation is played by the two pituitary gonadotropins, luteinizing hormone and follicle-stimulating hormone (FSH). Other hormones and growth factors also influence testicular function, often by modulating the gonadotropin effects. Moreover, a plethora of local paracrine and autocrine signals within the testis are known. The main testicular hormone, testosterone, a Leydig cell product, regulates spermatogenesis in seminiferous tubules in paracrine fashion. The other functions of testosterone are endocrine, occurring outside the testis. This chapter summarizes the main hormonal regulatory system of the testis, the hypothalamic–pituitary–testicular axis, and how its effects are modulated by other extratesticular hormones and local testicular factors.

THE RELATION BETWEEN NATURAL FECUNDITY AND RESPONSE TO FOLLICLE-STIMULATING HORMONE

1962 ◽  
Vol 25 (1) ◽  
pp. 137-144 ◽  
Author(s):  
ANNE McLAREN
Keyword(s):  
Artificial Selection ◽  
Response Curve ◽  
Follicle Stimulating Hormone ◽  
Ovarian Response ◽  
Ovulation Rate ◽  
The Other ◽  
Principal Effect ◽  
Low Levels ◽  
Selection For ◽  
Stimulating Hormone

SUMMARY A study was made of the response to induced ovulation of female mice from strains in which the spontaneous ovulation rate had increased as a result of artificial selection for litter size. In response to standard doses of follicle-stimulating hormone (FSH) within the physiological range, the number of eggs shed differed significantly among the three strains tested, in the direction expected on the basis of their spontaneous ovulation rates. This indicates that the principal effect of selection has been to increase the sensitivity of the ovary to FSH. In one strain, the possibility remains open that there may also have been some increase in the amount of FSH available. In response to larger doses of FSH, females from the strain with the highest spontaneous ovulation rate shed significantly fewer eggs than the other two groups. Selection must therefore have altered the shape of the dose-response curve, increasing the ovarian response at low levels of hormone and decreasing it at high levels.

Ovarian inhibition of peripheral plasma concentration of follicle stimulating hormone in prepuberal holstein heifers

1989 ◽  
Vol 6 (1) ◽  
pp. 35-40 ◽  
Author(s):  
W.G. Zollers ◽  
D.W. Forrest ◽  
W.J. Campbell ◽  
J.R. Parfet ◽  
M.F. Smith ◽  
...  
Keyword(s):  
Plasma Concentration ◽  
Follicle Stimulating Hormone ◽  
Peripheral Plasma ◽  
Stimulating Hormone

OESTROGEN SYNTHESIS IN RAT OVARIES IN VITRO: EFFECTS OF ENDOGENOUS AND EXOGENOUS GONADOTROPHINS

1972 ◽  
Vol 53 (3) ◽  
pp. 397-406 ◽  
Author(s):  
BRENDA ROBINSON ◽  
R. E. OAKEY
Keyword(s):  
Luteinizing Hormone ◽  
Follicle Stimulating Hormone ◽  
Oestrous Cycle ◽  
The Other ◽  
Ovarian Vein ◽  
Hormone Activity ◽  
In Vitro Effects ◽  
Stimulating Hormone

SUMMARY The rate of synthesis of [14C]oestrone and [14C]oestradiol-17β from [14C]testosterone in vitro by ovaries from rats at different stages of the oestrous cycle was measured. The rate of [14C]oestrogen synthesis was highest in ovaries taken from rats in pro-oestrus and lowest in ovaries taken from rats early in the dioestrous phase of the cycle. Rates of synthesis in ovaries obtained from rats in the late dioestrous stage were intermediate between the rates of the other groups. The rates of [14C]oestrogen synthesis at these periods of the cycle paralleled the concentrations of oestrogens in ovarian vein plasma reported by other authors. Gonadotrophin preparations with either luteinizing hormone activity or both follicle-stimulating hormone and luteinizing hormone activities had no effect on [14C]oestrogen synthesis by rat ovaries in vitro at any of these stages of the oestrous cycle.

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