Histological Typing of Lung Tumours

The WHO Histological Classification of Lung Tumours, published in 1967, has been revised. The main features are as follows: Squamous cell carcinoma (epidermoid carcinoma) has the same definition as in the original version, i.e., the identification of keratin and/or intercellular bridges by light microscopy. Three degrees of histological differentiation are described. Dysplasia and carcinoma in situ are discussed. Small cell carcinoma is divided into oat-cell carcinoma, an intermediate cell type and a category for oat-cell carcinomas combined with other major types. Adenocarcinoma includes the acinar, papillary and bronchiolo-alveolar forms and the solid carcinomas with mucus formation (previously part of the large cell carcinoma group). Mesothelial tumours are divided into fibrous, epithelial and biphasic subtypes. A number of less common tumours and tumour-like lesions are defined.

Download Full-text

Evidence for in situ expansion of diverse antitumor-specific cytotoxic T lymphocyte clones in a human large cell carcinoma of the lung

International Immunology ◽

10.1093/intimm/12.4.537 ◽

2000 ◽

Vol 12 (4) ◽

pp. 537-546 ◽

Cited By ~ 37

Author(s):

Hamid Echchakir ◽

Isabelle Vergnon ◽

Guillaume Dorothée ◽

Dominique Grunenwald ◽

Salem Chouaib ◽

...

Keyword(s):

Cell Carcinoma ◽

T Lymphocyte ◽

Cytotoxic T Lymphocyte ◽

Large Cell Carcinoma ◽

Large Cell

Download Full-text

Weight Optimized Neural Network Using Metaheuristics for the Classification of Large Cell Carcinoma and Adenocarcinoma from Lung Imaging

Current Signal Transduction Therapy ◽

10.2174/1574362411666160622095146 ◽

2016 ◽

Vol 11 (2) ◽

pp. 91-97 ◽

Cited By ~ 2

Author(s):

Thangavel Baranidharan ◽

Thangavel Sumathi ◽

Vadivelraj Chandra Shekar

Keyword(s):

Neural Network ◽

Cell Carcinoma ◽

Large Cell Carcinoma ◽

Large Cell ◽

Lung Imaging

Download Full-text

P3.02-097 Clinicopathological Features and Genetic Landscape of Pulmonary Large Cell Carcinoma under 2015 WHO Classification of NSCLC

Journal of Thoracic Oncology ◽

10.1016/j.jtho.2017.09.1626 ◽

2017 ◽

Vol 12 (11) ◽

pp. S2272-S2273

Author(s):

R. Liu ◽

T. Shi ◽

X. Li ◽

S. Wei ◽

G. Chen ◽

...

Keyword(s):

Cell Carcinoma ◽

Who Classification ◽

Large Cell Carcinoma ◽

Large Cell ◽

Clinicopathological Features ◽

Genetic Landscape

Download Full-text

Lobectomy with Bronchoplastic Procedures for Lung Cancer

Tumori Journal ◽

10.1177/030089167906500513 ◽

1979 ◽

Vol 65 (5) ◽

pp. 643-648 ◽

Cited By ~ 1

Author(s):

Maurizio Valente ◽

Cesare Grandi ◽

Ignazio Cataldo ◽

Giorgio Pizzocaro ◽

Gianni Ravasi

Keyword(s):

Lung Cancer ◽

Cell Carcinoma ◽

Squamous Carcinoma ◽

Large Cell Carcinoma ◽

Distant Metastases ◽

Large Cell ◽

Sleeve Lobectomy ◽

Surgical Specimen ◽

Bronchoplastic Procedures ◽

Oat Cell Carcinoma

From April 1970 to October 1977, 19 patients with lung cancer of the upper lobar bronchus orifice underwent radical lobectomy with major bronchus resection. Sleeve lobectomy was accomplished in 11 cases and wedge lobectomy in the remaining 8. The length of the free bronchial margin in the surgical specimen was less than 1 cm in 3 cases, but limited pulmonary reserve did not allow pneumonectomy. Squamous carcinoma was diagnosed in 14 patients, adenocarcinoma in 2, oat-cell carcinoma in 2, and large cell carcinoma in one. Most cases (70%) were pathological stage I. There was one operative death due to anastomotic leakage (5%), and another patient required pneumonectomy completion. Of 13 patients with non oat-cell carcinoma and adequate bronchial resection, none had local recurrence: 3 patients developed distant metastases, and 10 are alive and disease-free after a follow-up period ranging from 16 to 104 months. The authors conclude that in selected lung cancer patients lobectomy with bronchoplastic procedures is superior to pneumonectomy for tissue sparing advantages.

Download Full-text

Das anaplastische Lungenkarzinom des Hundes

Veterinary Pathology ◽

10.1177/030098587301000203 ◽

1973 ◽

Vol 10 (2) ◽

pp. 102-113 ◽

Cited By ~ 5

Author(s):

H. Stünzi

Keyword(s):

Cell Carcinoma ◽

Large Cell Carcinoma ◽

Large Cell ◽

Domestic Animals ◽

Small Cell ◽

Round Cell ◽

Histological Criteria ◽

Pulmonary Tumors ◽

Pulmonary Neoplasia

Of 86 canine pulmonary tumors five had the histological criteria of undifferentiated small-cell carcinoma and two of undifferentiated large-cell carcinoma. The five small-cell anaplastic careinomas could be divided, as is the case in man, according to strict histological criteria into fusiform, lymphocyte-like, and polygonal subgroups. In the fusiform and round-cell subgroups there were focal sites of equivocal differentiation towards epidermoid careinoma or adenocarcinoma. These local changes must be considered in making a diagnosis, but it was not possible to positively determine the behavior of anaplastic, epidermoid or glandular carcinomas. The classification of pulmonary carcinomas of domestic animals has significance not only for experimental oncology but also for clarification of the cause of pulmonary neoplasia. Anaplastic pulmonary carcinomas have not been found in the cat.

Download Full-text

Bilateral Diffuse Malignant Melanoma of the Uvea Associated with Large Cell Carcinoma, Giant Cell Type, of the Lung

Ophthalmologica ◽

10.1159/000309413 ◽

1984 ◽

Vol 189 (4) ◽

pp. 221-228 ◽

Cited By ~ 25

Author(s):

Jan Ulrik Prause ◽

Ove Aksel Jensen ◽

Finn Eisgart ◽

Ulla Hansen ◽

Marianne Kieffer

Keyword(s):

Malignant Melanoma ◽

Cell Carcinoma ◽

Giant Cell ◽

Large Cell Carcinoma ◽

Large Cell ◽

Cell Type ◽

Giant Cell Type

Download Full-text

Prognostic Significance of the Cyto-Histological Classification of Infiltrating Cervical Epidermoid Carcinoma

Tumori Journal ◽

10.1177/030089168006600206 ◽

1980 ◽

Vol 66 (2) ◽

pp. 183-190 ◽

Cited By ~ 2

Author(s):

Paolo Dalla Palma ◽

Carla Arslan Pagnini ◽

Giuseppe de Laurentiis

Keyword(s):

Cell Carcinoma ◽

Classification System ◽

Survival Rates ◽

Prognostic Significance ◽

Large Cell Carcinoma ◽

Large Cell ◽

Small Cell ◽

Histological Classification ◽

Cervical Carcinomas

One hundred-fifty-five cervical carcinomas were classified according to the Wentz and Reagan (21) cyto-histological system, and correlated to 5 year survival rates. This classification subdivides epidermoid carcinomas into three sub-groups: keratinizing carcinoma, large cell carcinoma, and small cell carcinoma. No significant differences between one group and another were observed. The importance of the type of therapy in conditioning the significance of this classification system is discussed.

Download Full-text