Small-Cell Lung Cancer: Importance of Fiberoptic Bronchoscopy in the Evaluation of Complete Remission

1989 ◽  
Vol 75 (3) ◽  
pp. 266-268 ◽  
Author(s):  
Maurizio Tondini ◽  
Adriano Rizzi
Keyword(s):  
Lung Cancer ◽  
Complete Remission ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Fiberoptic Bronchoscopy ◽  
Small Cell ◽  
Small Cell Lung ◽  
X Ray ◽  
Chest X Ray

The authors report their eight-year experience on the methodical of fiberbronchoscopy in the evaluation of complete remission in 140 patients affected by small-cell lung cancer. The higher reliability of fiberbronchoscopy than of standard chest X-ray is emphasized.

Combined small-cell and non-small-cell lung cancer.

1989 ◽  
Vol 7 (5) ◽  
pp. 607-612 ◽  
Author(s):  
M D Mangum ◽  
F A Greco ◽  
J D Hainsworth ◽  
K R Hande ◽  
D H Johnson
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Needle Aspiration ◽  
Small Cell ◽  
Small Cell Lung ◽  
X Ray ◽  
Response To Chemotherapy ◽  
Chest X Ray ◽  
Combined Subtype

Nine (2%) of 429 small-cell lung cancer (SCLC) patients seen at Vanderbilt University between 1977 and 1983 had a combined subtype SCLC at diagnosis (ie, small-cell carcinoma plus squamous cell or adenocarcinoma). Staging procedures and chemotherapy treatment were uniform for all 429 patients. The diagnosis of combined histology was established via bronchoscopy (six patients), needle aspiration biopsy (one), lymph node biopsy (one), and thoracotomy (one). The clinical characteristics of the combined subtype patients were similar to patients with other subtypes of SCLC (ie, there were no differences in median age, sex, performance status, and stage of disease). However, patients with a combined subtype histology had a higher incidence of peripheral lesions on chest x-ray (56% v 14%, P less than .001) and a lower median lactate dehydrogenase (LDH) (301 IU/L v 341 IU/L, P = .0002) at diagnosis. The overall response to chemotherapy (57% v 78; P = .5) and the median survival (8 months v 10 months; P = .4) of the combined subtype patients were similar to patients with other subtypes of SCLC. Two (22%) combined histology patients survived greater than or equal to 5 years. Both had had surgical resection in addition to chemotherapy. These data suggest that the combined subtype of SCLC is clinically similar to pure SCLCs and that surgery may play a prominent role in the management of these tumors. The possibility of a combined histology tumor should be considered in patients thought to have SCLC on the basis of limited biopsy material, such as a needle aspiration or bronchial biopsy, and when the primary lesion is peripherally located on chest x-ray.

Cisplatin plus etoposide consolidation following cyclophosphamide, doxorubicin, and vincristine in limited small-cell lung cancer.

1988 ◽  
Vol 6 (3) ◽  
pp. 451-456 ◽  
Author(s):  
L H Einhorn ◽  
J Crawford ◽  
R Birch ◽  
G Omura ◽  
D H Johnson ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Complete Remission ◽  
Small Cell Lung Cancer ◽  
Induction Therapy ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Thoracic Irradiation ◽  
Consolidation Phase ◽  
Disease Free

From June 1982 through October 1985, the Southeastern Cancer Study Group randomized patients with limited small-cell lung cancer (SCLC) to cyclophosphamide plus doxorubicin (Adriamycin, Adria Laboratories, Columbus, OH) plus vincristine (CAV) for six cycles v CAV plus concomitant thoracic irradiation as induction therapy. Patients achieving either a complete or partial response and remaining in remission after completion of induction therapy were subsequently randomized to consolidation chemotherapy consisting of cisplatin 20 mg/m2 X 4 plus etoposide (VP-16) 100 mg/m2 X 4 every 4 weeks for two courses v no further therapy. There were 160 patients entered on the consolidation phase and 148 were fully evaluable. The median survival for patients randomized to cisplatin plus VP-16 (PVP16) from start of CAV chemotherapy was 97.7 weeks, compared with 68 weeks for the no-consolidation arm (P = .0094). PVP16 consolidation also significantly increased the duration of remission, with median durations of 49 weeks v 28 weeks (P = .0008). The median durations for partial remission were 41 weeks v 23 weeks (P = .013), and for complete remission, 52 weeks v 30.5 weeks (P = .0091). Furthermore, 18 patients on PVP16 consolidation remain in a continuous complete remission for 12+ months and 13 of these are continuously disease free 2+ years. Eight patients randomized to no consolidation remain in a continuous complete remission, with only four patients disease free 2+ years. PVP16 consolidation has significantly improved the duration of remission and overall survival and appears capable of improving the cure rate in limited SCLC.

scholarly journals Does a routine post brush bronchial wash increase the yield in diagnosis of lung cancer?

2017 ◽  
Vol 5 (7) ◽  
pp. 2878 ◽  
Author(s):  
Mathan Raj S. ◽  
Sowmiya Murali
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Fiberoptic Bronchoscopy ◽  
Small Cell ◽  
Fibreoptic Bronchoscopy ◽  
Small Cell Lung ◽  
Brush Cytology ◽  
Tissue Samples ◽  
Bronchial Wash

Background: Lung cancer is the most common cause of cancer-related death in both men and women. 80% of the lung cancers are non-small cell lung cancer (NSCLC) and 20% are small cell lung cancer (SCLC). Flexible fiberoptic bronchoscopy is commonly used for diagnostic and staging purposes. Endoscopically visible abnormalities are approached with traditional biopsy forceps, brushings, and washings. Objectives were to assess the yield of bronchial washings, brush cytology and to compare the yield of pre and post brush bronchial washings.Methods: Patients with suspicion of lung cancer will be subjected to bronchoscopy using flexible fibreoptic bronchoscopy. Multiple procedures performed for the retrieval of tissue samples will include bronchial washings (pre and post brushing), bronchial brushing and endobronchial biopsy.Results: A total of 57 cases were included in the study with 40 (70.2%) males and 17 females (29.8%). The yield of pre-brush bronchial washings, post brush bronchial washings and bronchial brushings were 31.6% (18 of 57), 31.6% (18 of 57) and 61.4% (35 of 57) respectively. Biopsy was positive for malignancy in 11 of 19 (58.2%) cases. Adenocarcinoma was the commonest type seen in 32 (56.1%) patients. Of the 27 cases with endobronchial growth 11 were adenocarcinoma (40.7%).Conclusions: There was no difference between the yield of pre-brush washing and post brush washing. The yield of brush cytology was significantly more than the yield of bronchial washings. There is an increase in the yield after adding both pre and post brush bronchial wash. 

scholarly journals Pathological analysis of hesperetin-derived small cell lung cancer by artificial intelligence technology under fiberoptic bronchoscopy

2021 ◽  
Vol 18 (6) ◽  
pp. 8538-8558
Author(s):  
Xiaoli Zhang ◽  
◽  
Ziying Yu ◽  
Keyword(s):  
Artificial Intelligence ◽  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Cell Lung Cancer ◽  
Fiberoptic Bronchoscopy ◽  
Small Cell ◽  
Small Cell Lung ◽  
Artificial Intelligence Technology

<abstract> <p>Lung cancer is one of the most common tumors. There are 1.8 million new cases worldwide each year, accounting for about 13% of all new tumors. Lung cancer is the most important cause of cancer-related deaths. 1.4 million people die of lung cancer each year. This article uses artificial intelligence technology to analyze the pathology of hesperetin-derived small cell lung cancer under fiberoptic bronchoscopy. This article takes 48 lung slice samples as the research object. Among them, 36 cases of lung small cell carcinoma have history slices from Lhasa City Institute of Biology, the patient has complete cases, and the other 12 normal lung slices come from Xinjiang Biotechnology Laboratory. In this paper, the above-mentioned 36 lung cancer slices became the study group, and 12 normal slices became the reference group. This article presents a method for hesperetin-fiber bronchoscope to study the pathological mechanism of lung small cell carcinoma (H-FBS), which is used to study slices. The above-mentioned 48 samples were taken for slice observation. First, the 48 slices were technically tested by artificial intelligence fiber bronchoscope combined with hesperetin derivatives, and then the slice observation results were verified by CTC technology. In addition, in each step, the C5orf34 in the tissue is detected separately, which is beneficial to adjust the content of C5orf34 so that the treatment of lung cancer can control the development of lung cancer under fiberoptic bronchoscopy. Experimental results show that the diagnostic accuracy rate of this method is 97.9%, which is higher than that of lung biopsy (89%); compared with multiple CTC detection, the cost is low and the time is shor.</p> </abstract>

scholarly journals A Case of Salvage Surgery for Small Cell Lung Cancer That Locally Relapsed Five Years After Complete Remission

Haigan ◽  
2019 ◽  
Vol 59 (2) ◽  
pp. 163-167
Author(s):  
Masatoshi Kanayama ◽  
Toshihiro Osaki ◽  
Yukiko Fukuichi ◽  
Kenichi Kobayashi ◽  
Manabu Yasuda ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Complete Remission ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Salvage Surgery ◽  
Small Cell ◽  
Small Cell Lung
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