scholarly journals Anaplastic Large T-Cell Lymphoma in the Intestine of Dogs

2019 ◽  
Vol 56 (6) ◽  
pp. 878-884 ◽  
Author(s):  
Lauren W. Stranahan ◽  
Derick Whitley ◽  
Tuddow Thaiwong ◽  
Matti Kiupel ◽  
Fabiano Oliveira
Keyword(s):  
Gastrointestinal Tract ◽  
T Cell ◽  
Intestinal Perforation ◽  
Cell Lymphoma ◽  
Cell Receptor ◽  
T Cell Lymphoma ◽  
Intestinal Lymphoma ◽  
Treatment Protocols ◽  
Selection Of

Anaplastic large T-cell lymphoma (ALTCL) is a rare subtype of non-Hodgkin T-cell lymphoma that occasionally occurs in the gastrointestinal tract of humans. Enteropathy-associated T-cell lymphoma (EATL) type 1 is the most common type of intestinal lymphoma in dogs, and ALTCL has not previously been reported in the intestinal tract of dogs. Thirteen dogs with intestinal masses diagnosed as intestinal lymphoma with anaplastic morphology were reviewed. Clinical data, including treatment protocols, were available for 11 cases. Immunohistochemistry for CD3, CD20, and CD30 was performed for all cases in addition to PCR for Antigen Receptor Rearrangements (PARR) for assessment of clonality. Eight (62%) of the cases presented with intestinal perforation, and all cases had 1 or more masses arising from the small intestine. Histologically, all cases were characterized by transmural infiltrates of large, CD3-positive and frequently CD30-positive cells. Neoplastic T cells had marked anisocytosis and anisokaryosis, prominent nucleoli, and occasionally indented to reniform nuclei. There was abundant necrosis and inflammation with occasional vascular invasion within neoplastic masses. All cases had a monoclonal T-cell receptor γ gene rearrangement. The median survival time was 5 days, with 1 dog surviving 2 years after the initial diagnosis. ALTCL can occur as an aggressive transmural lymphoma in the gastrointestinal tract of dogs and commonly causes intestinal perforation. ALTCL can be differentiated from EATL type 1 and might have implications for accurate prognostication and selection of therapeutic options in the future.

scholarly journals IgA Antibodies Against Gliadin and Tissue Transglutaminase in Dogs With Chronic Enteritis and Intestinal T-Cell Lymphoma

2017 ◽  
Vol 55 (1) ◽  
pp. 98-107 ◽  
Author(s):  
I. Matsumoto ◽  
K. Uchida ◽  
K. Nakashima ◽  
S. Hiyoshi ◽  
J. K. Chambers ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
Tissue Transglutaminase ◽  
Cell Receptor ◽  
T Cell Lymphoma ◽  
Igg Antibodies ◽  
Intestinal Lymphoma ◽  
Serum Iga ◽  
Iga Antibodies ◽  
Clonality Analysis

Molecular clonality analysis of T-cell receptor (TCR) genes for diagnosing T-cell lymphoma is widely used in veterinary medicine. However, differentiating chronic enteritis (CE) from intestinal lymphoma is challenging because of the incompatibility between histopathologic and clonality analysis results. On the basis of findings that canine intestinal T-cell lymphoma and celiac disease share some common features, we conducted serologic examinations in combination with histopathologic and T-cell receptor clonality analyses in 48 dogs diagnosed with either CE or intestinal lymphoma. Immunoglobulin A (IgA) and immunoglobulin G (IgG) antibodies against gliadin and tissue transglutaminase (tTG) were quantitatively measured using ELISA. The conditions were classified according to the histopathologic diagnosis, clonality analysis, and combined histopathologic/clonality analysis. Histopathologic analysis showed that dogs with intestinal lymphoma were likely to have high levels of serum IgA antibodies against gliadin and tTG, and serum IgG antibodies against tTG. No correlation between the diagnosed groups and control group was observed in the results of the clonality analysis and histopathologic/clonality analysis. It is interesting that dogs with intestinal lymphoma had a higher serum IgA titer against gliadin and tTG than did dogs with CE. These results suggest an association between repetitive inflammatory stimulation by gliadin peptides and subsequent intestinal lymphoma in dogs.

scholarly journals Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Koen Debackere ◽  
Lukas Marcelis ◽  
Sofie Demeyer ◽  
Marlies Vanden Bempt ◽  
Nicole Mentens ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Lymphoma ◽  
Ex Vivo ◽  
Cell Receptor ◽  
T Cell Lymphoma ◽  
Peripheral T Cell Lymphoma ◽  
Fusion Transcripts ◽  
Not Otherwise Specified

AbstractPeripheral T-cell lymphoma (PTCL) is a heterogeneous group of non-Hodgkin lymphomas with poor prognosis. Up to 30% of PTCL lack distinctive features and are classified as PTCL, not otherwise specified (PTCL-NOS). To further improve our understanding of the genetic landscape and biology of PTCL-NOS, we perform RNA-sequencing of 18 cases and validate results in an independent cohort of 37 PTCL cases. We identify FYN-TRAF3IP2, KHDRBS1-LCK and SIN3A-FOXO1 as new in-frame fusion transcripts, with FYN-TRAF3IP2 as a recurrent fusion detected in 8 of 55 cases. Using ex vivo and in vivo experiments, we demonstrate that FYN-TRAF3IP2 and KHDRBS1-LCK activate signaling pathways downstream of the T cell receptor (TCR) complex and confer therapeutic vulnerability to clinically available drugs.

scholarly journals Extranodal NK/T-cell lymphoma, nasal type presenting as primary intestinal lymphoma vs intestinal T-cell lymphoma: A borderline diagnostic category in the revised WHO classification

2021 ◽  
Vol 25 ◽  
pp. 200534
Author(s):  
Brady E. Beltrán ◽  
Mario L. Marques-Piubelli ◽  
M. Pilar Quiñones ◽  
Esther Cotrina ◽  
Eugenio A. Palomino ◽  
...  
Keyword(s):  
T Cell ◽  
Who Classification ◽  
Cell Lymphoma ◽  
Diagnostic Category ◽  
T Cell Lymphoma ◽  
Intestinal Lymphoma ◽  
Nasal Type ◽  
Nk T Cell

Diagnosis of T-cell lymphoma using beta F1, anti-T-cell receptor beta chain antibody

1989 ◽  
Vol 15 (3) ◽  
pp. 239-247 ◽  
Author(s):  
A. S. Krajewski ◽  
M. W. Myskow ◽  
D. M. Salter ◽  
D. S. Cunningham ◽  
E. F. Ramage
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Lymphoma ◽  
Cell Receptor ◽  
T Cell Lymphoma ◽  
Beta Chain ◽  
T Cell Receptor Beta ◽  
Receptor Beta

HTLV–I Associated and Non–Associated Primary T–Cell Lymphoma of Gastrointestinal Tract

1993 ◽  
Vol 9 (4-5) ◽  
pp. 399-405 ◽  
Author(s):  
Takeshi Tokioka ◽  
Yoshinori Shimamoto ◽  
Osamu Tokunaga ◽  
Masaya Yamaguchi
Keyword(s):  
Gastrointestinal Tract ◽  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma

Angioimmunoblastic T-Cell Lymphoma With Cutaneous Involvement: A Case Report With Subtle Histologic Changes and Clonal T-Cell Proliferation

2004 ◽  
Vol 128 (10) ◽  
pp. e122-e124
Author(s):  
Chien-Tai Huang ◽  
Shih-Sung Chuang
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Gene Rearrangement ◽  
Cell Lymphoma ◽  
Paraffin Section ◽  
Cell Receptor ◽  
T Cell Lymphoma ◽  
Chain Gene ◽  
Angioimmunoblastic T Cell Lymphoma ◽  
Lymphoid Infiltrate

Abstract Angioimmunoblastic T-cell lymphoma is a nodal peripheral T-cell lymphoma that rarely involves the skin. We describe a 62-year-old Taiwanese man who developed a second relapse of angioimmunoblastic T-cell lymphoma with generalized erythroderma and numerous plaquelike and nodular lesions. Biopsy of the erythematous skin lesion demonstrated mild infiltrate of atypical small lymphocytes, some with clear cytoplasm. The lymphoid infiltrate was located mainly around skin appendages and in the upper dermis without epidermotropism. Immunohistochemically, these atypical lymphocytes expressed CD3. Polymerase chain reaction analysis for T-cell receptor γ-chain gene rearrangement using paraffin section showed the same-sized monoclonal bands in the skin and 2 previous nodal biopsies. We conclude that the histologic features of angioimmunoblastic T-cell lymphoma involving skin may be very subtle, showing only mild lymphoid infiltrate. Awareness of the history of angioimmunoblastic T-cell lymphoma with ancillary studies, including clonality testing for T-cell receptor gene rearrangement, is crucial for reaching an accurate diagnosis.

scholarly journals Primary Pulmonary T-Cell Lymphoma in a Human T-Lymphotropic Virus Type-1 Carrier Showing Atypical Shadow

2010 ◽  
Vol 5 (4) ◽  
pp. 558-559 ◽  
Author(s):  
Shojiro Minomo ◽  
Takayuki Takimoto ◽  
Osamu Morimura ◽  
Akane Watanabe ◽  
Yasuhiro Nagate ◽  
...  
Keyword(s):  
T Cell ◽  
Virus Type ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
T Lymphotropic Virus

scholarly journals T-Cell Lymphoma in a Patient with Neurofibromatosis Type 1 and AIDS

2017 ◽  
Vol 10 (1) ◽  
pp. 161-168
Author(s):  
Izana Junqueira de Castro ◽  
Esther Botelho Soares da Silva ◽  
Talita Rezende dos Santos ◽  
Amanda Barroso de Freitas ◽  
Inara Junqueira de Castro ◽  
...  
Keyword(s):  
T Cell ◽  
Neurofibromatosis Type 1 ◽  
Cell Lymphoma ◽  
Neurofibromatosis Type ◽  
T Cell Lymphoma ◽  
Malignant Neoplasms ◽  
Non Hodgkin Lymphoma ◽  
Dominant Disease ◽  
Chemotherapeutic Treatment

Neurofibromatosis type 1 (NF1) and AIDS are risk factors for the development of malignant neoplasms, including hematological malignancies, such as non-Hodgkin lymphoma. NF1 is an autosomal dominant disease that primarily manifests as café-au-lait spots, dermal neurofibromas, axillary and/or inguinal ephelides or freckles, plexiform neurofibromas, Lisch nodules, and bone deformities. In this report, we present a 38-year-old female patient with NF1 from childhood and AIDS who developed peripheral T-cell lymphoma with good response to chemotherapeutic treatment.

Primary gastric T-cell lymphoma of suppressor-cytotoxic (CD8+) phenotype: Discordant expression of T-cell receptor subunit βF1, CD7, and CD3 antigens

1990 ◽  
Vol 21 (8) ◽  
pp. 872-874 ◽  
Author(s):  
Diponkar Banerjee ◽  
John C. Walton ◽  
Thomas A. Jory ◽  
Catherine Crukley ◽  
Margaret Meek
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Lymphoma ◽  
Cell Receptor ◽  
T Cell Lymphoma ◽  
Receptor Subunit
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