scholarly journals Preoperative Cimetidine — Effects on Gastric Fluid

1980 ◽  
Vol 8 (4) ◽  
pp. 464-468 ◽  
Author(s):  
P. J. Barnes ◽  
J. H. Havill
Keyword(s):  
Gastric Fluid ◽  
Blind Study ◽  
Double Blind Study ◽  
Gastric Aspirate ◽  
Double Blind ◽  
Induction Of Anaesthesia

A double blind study of 44 patients (24 placebo, 20 cimetidine) was undertaken to determine the effect of cimetidine on the pH and volume of gastric fluid during anaesthesia. The pH was significantly higher on cimetidine-treated patients than placebo-treated patients at 0, 15, 30 and 45 minutes following intubation. At induction of anaesthesia, mean pH on cimetidine was 4.5 and on placebo mean pH was 2.0. Approximately 70% of patients on cimetidine and 20% on placebo recorded a pH above 2.5 during anaesthesia. The reason for a pH recording of less than 2.5 in seven patients on cimetidine could not be ascertained. Mean volume of gastric aspirate was slightly lower in the cimetidine group at 0, 15, 30 and 45 minutes, but the differences were not significant.

scholarly journals Peritonsillar Infiltration with Bupivacaine for Paediatric Tonsillectomy

1994 ◽  
Vol 22 (6) ◽  
pp. 679-682 ◽  
Author(s):  
J. C. Stuart ◽  
F. B. Macgregor ◽  
C. S. Cairns ◽  
H. R. Chandrachud
Keyword(s):  
Pain Score ◽  
Severe Pain ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind ◽  
Peritonsillar Infiltration ◽  
Induction Of Anaesthesia ◽  
To Receive

In a double-blind study forty-two children scheduled for elective adenotonsillectomy were randomized to receive peritonsillar infiltration, following induction of anaesthesia, with either 0.25% plain bupivacaine or 0.9% saline, 0.5 ml/kg to a maximum of 10 ml. The children were assessed on awakening, and then 10 minutes, 1 hour, 4 hours and 24 hours later. On each occasion the observer gave the child a pain score from 1 (no pain) to 5 (severe pain). The scores on awakening and after 10 minutes were significantly lower in the bupivacaine group (P< 0.05, Mann-Whitney U test). Thereafter there was no difference between the groups. The authors conclude that peritonsillar infiltration with bupivacaine is only moderately useful as analgesia for children having tonsillectomy.

Double-Blind Study of Antihistaminic Drugs

1973 ◽  
Vol 35 (5) ◽  
pp. 627-633
Author(s):  
Masayuki SHIMIZU ◽  
Yoshiko HIDAKA ◽  
Ryuhji TAKEUCHI
Keyword(s):  
Blind Study ◽  
Double Blind Study ◽  
Double Blind ◽  
Antihistaminic Drugs
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