ABSTRACT… Background: Propofol is wonderful drug for short duration procedures. However, pain on injection of propofol, which has been reported to occur in 28-90% of patients, is a major drawback to its use. Different methods have been used to decrease this pain but intravenous lignocaine is most commonly used pretreatment. Period:................... Methods: A comparative, randomized, double blind study was undertaken to compare the efficacy of three drugs for prevention of pain on propofol injection on induction of anaesthesia. 100 patients of ASA status 1 and 2 posted for General Surgery were allocated randomly in four groups of 25 each, using computer- generated table of random numbers. Venous occlusion was made with tourniquet for one minute. The study drug intravenous lignocaine 1% 2ml (group1), Ketamine 10mg(group2), Dexamethasone 4mg in 2ml (group 3) or normal saline 2ml (group 4) was administered over 10 seconds according to random number. There after occlusion was released and intravenous propofol was given. After the first 25% of propofol given, patients were asked for intensity of pain they experienced.Conclusion: It was concluded that Lignocaine, Ketamine and Dexamethasone significantly reduces the pain induced by Propofol injection pain as compared to Placebo but there is no difference in efficacy for prevention of pain among these three groups Key words: Propofol, pain, intravenous injection.Results: Lignocaine, Ketamine and Dexamethasone significantly reduces the pain on propofol injection in comparison to placebo, but there was no significant difference in pain score among groups 1, 2, 3. There was no significant difference in recall of pain among groups 1, 2, and 3. Although there was significant difference between placebo group and other three groups
Effect of Alkalinisation of Lignocaine for Propofol Injection Pain: A Prospective, Randomised, Double-Blind Study