Low dose magnesium sulphate regimen and maternal outcome of patients with eclampsia

Background: Preeclampsia, a serious pregnancy complication which is commonly characterized by high blood pressure, presence of protein in the urine and sometimes swelling in women's feet, legs and hands. With this condition, patient’s high blood pressure often results in seizures. Generally, the outcome remains good, however, eclampsia can be life threatening and disastrous.Methods: This cross-sectional study considered 114 patients who meet inclusion criteria and agreed to will-fully participate in the study were evaluated for different parameters. Patients who developed eclampsia during intra-natal and postnatal period were included in the study. The aim of the study was to evaluate the maternal outcome among all patients of eclampsia treated with low magnesium sulphate dosage therapy. Results: The present study revealed, very low fit recurrence rate, low mortality rate, zero treatment failure rate, no toxicity and (99.12%) success rate.Conclusions: Apart from zero percent treatment failure rate, Low maternal mortality and fit recurrence rate encouraged us to continue the treatment with low dose MGSO4 regimen. Thus, low dose magnesium sulphate has been found very effective in treating the eclmpsia and at the same time maintains the high safety margin.

Experimental Study on Self Compacting Fibrous Concrete Comprising Magnesium Sulphate Solution Treated Recycled Aggregates

It appears that the awareness and intentions to use recycled concrete aggregate (RCA) in concrete are expanding over the globe. The production of self-compacting concrete (SCC) using RCA is an emerging field in the construction sector. However, the highly porous and absorptive nature of adhered mortar on RCA’s surface leads to reduced concrete strength, which can be removed with the application of various techniques, such as acid treatment. This study investigated the effect of the partial replacement of silica fume by cement and natural aggregate (NA) by RCA with and without steel fibre. The used RCA was treated with magnesium sulphate solution. It was immersed in solutions with different concentrations of 10%, 15% and 20% and for different periods of 5, 10 and 15 days. Sixteen mixes were prepared, which were divided into six groups with or without 1% of steel fibre content. The fresh properties, compressive strength, split tensile strength and impact resistance were examined. The results revealed that the strengths of the mixes with 20% RCA were marginally better than those of the control mixes. The compressive strength and split tensile strength were reduced by 34% and 35% at 60% RCA content, respectively, as compared to the control mixes.

Comparative evaluation of sulphur sources on growth, yield and quality of garlic (Allium sativum L.)

Sulphur is a prime nutrient in Allium crops. Garlic fertilization with ammonium-based sulphur fertilizers in low pH soils is being practiced by farmers that culminate the soil acidity, which has an adverse effect on plant growth. Hence a field experiment was conducted at Horticultural Research Station, Woodhouse farm, Ooty, the Nilgris in 2021 to evaluate the appropriate sulphur sources and their levels for garlic at acidic hilly soil using four sulphur sources viz., potassium sulphate, magnesium sulphate, zinc sulphate and ammonium phosphate sulphate and three levels viz., 0, 40, 60 kg ha-1. Garlic variety Ooty 2 was used as test crop. The results revealed that application of magnesium sulphate @ 60 kg ha-1 produced the highest plant height, leaf numbers, clove numbers bulb-1, neck thickness, polar diameter, equatorial diameter, the weight of 10 cloves, fresh weight, dry weight and bulb yield (16.78 t ha-1) of garlic. Quality parameters viz., total soluble solids, ascorbic acid and total phenols of garlic bulbs were improved by the application of potassium sulphate @ 60 kg ha-1. Sulphur source of Magnesium sulphate had a minimal effect of rendering acidity to soil measured in terms of pH (4.74) and exchangeable acidity (0.22 meq 100 g-1). Hence, the promising source for acidic hilly soil and garlic crop was found to be magnesium sulphate @ 60 kg ha-1 followed by potassium sulphate @ 60 kg ha-1. This particular investigation focuses not only on yield improvement but also on maintaining soil quality of the area.

Spinal Myoclonus after Sub-Arachnoid Block

Spinal myoclonus is a rare and less known sequel e after central neuraxial blocks and hereby we present a case of 68 yrs old lady undergoing removal of infected femur implant under sub-arachnoid block (SAB), developing myoclonus after the procedure ended but before regression of block. It was treated successfully with an infusion of lignocaine and magnesium sulphate. The patient was called in for follow-up after one week and had no any complains thereafter. Keywords: Spinal myoclonus, sub-arachnoid block, neuraxial block

Stating the obvious: intravenous magnesium sulphate should be the first parenteral bronchodilator in paediatric asthma exacerbations unresponsive to first-line therapy

What is the most appropriate second-line intravenous bronchodilator treatment when a child with a severe asthma attack is not responsive to initial inhaled therapy? The second-line treatment options for acute asthma include parenteral β2-agonists, methylxanthine and magnesium sulphate (MgSO4). There is a poor evidence-base to inform this decision. This review argues that intravenous MgSO4 is the obvious treatment of choice for this situation as the initial treatment based on current knowledge. We describe the mode of action, scope and limitations of MgSO4, safety profile, economic impact, comparisons of the alternatives, and finally, what the guidelines say. This review explores the suitability of intravenous MgSO4 as a pragmatic and safe initial second-line therapy for children unresponsive to initial asthma management.