Intravenous Nitroglycerin during Surgery for Coronary Artery Disease

Intravenous infusions of nitroglycerin decreased systemic systolic, pulmonary systolic and wedge pressures in β-blocked patients anaesthetised for coronary artery surgery with high dose of fentanyl without changing heart rate, diastolic pressure, or cardiac index, thus leading to an improvement in endocardial viability ratio. The use of a nitroglycerin bolus to abort an acute myocardial ischaemic episode is described.

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Haemodynamic Effects of Dobutamine in Patients with Coronary Artery Disease

Journal of International Medical Research ◽

10.1177/030006057700500102 ◽

1977 ◽

Vol 5 (1) ◽

pp. 10-17 ◽

Cited By ~ 3

Author(s):

B Magnani ◽

E Ambrosioni ◽

A Branzi ◽

F Picchio ◽

P Capitanucci

Keyword(s):

Coronary Artery Disease ◽

Heart Rate ◽

Cardiac Output ◽

Coronary Artery ◽

Diastolic Pressure ◽

Left Ventricular ◽

Haemodynamic Effects ◽

Dose Infusion ◽

Pulmonary Arterial ◽

Artery Disease

The haemodynamic effects of the infusion of dobutamine in dosages of 2·5, 5·0 and 10·0 μg/kg/min were studied in twelve patients with coronary artery disease. At the lowest dose, infusion of dobutamine caused a significant increase in cardiac output; greater increases occurred with doses of 5·0 and 10·0 μg/kg/min. The means by which the myocardium produced the increase in cardiac output differed according to the dose of the drug; 2·5 and 5·0 μg/kg/min produced an increase in stroke volume without any significant variation in the heart rate. At the highest dose rate, an increase in heart rate made a distinct contribution to the overall increase in output. The ventricular dp/dt max. increased at all three dosages. Blood pressure, pulmonary arterial and capillary pressure, and left ventricular and diastolic pressure did not show any significant change. The separation of the inotropic and the chronotropic effects of dobutamine according to the infused dose appears to have extremely interesting clinical implications.

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Chronomes (rhythms, chaos and age and disease trends) of heart rate variability (HRV) in patients with coronary artery disease (CAD)

Journal of Cardiothoracic and Vascular Anesthesia ◽

10.1016/s1053-0770(98)90287-7 ◽

1998 ◽

Vol 31 ◽

pp. 46

Author(s):

K OTSUKA

Keyword(s):

Coronary Artery Disease ◽

Heart Rate ◽

Heart Rate Variability ◽

Coronary Artery ◽

Artery Disease

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2063 Heart-rate variability reflects the severity of coronary artery disease

European Heart Journal ◽

10.1016/s0195-668x(03)95057-3 ◽

2003 ◽

Vol 24 (5) ◽

pp. 381

Author(s):

O MANFRINI

Keyword(s):

Coronary Artery Disease ◽

Heart Rate ◽

Heart Rate Variability ◽

Coronary Artery ◽

Artery Disease

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The influence of cardiac rehabilitation on heart rate variability indices in men with type 2 diabetes and coronary artery disease

Diabetes and Vascular Disease Research ◽

10.1177/14791641211020184 ◽

2021 ◽

Vol 18 (3) ◽

pp. 147916412110201

Author(s):

Katarzyna Szmigielska ◽

Anna Jegier

Keyword(s):

Type 2 Diabetes ◽

Coronary Artery Disease ◽

Heart Rate ◽

Heart Rate Variability ◽

Coronary Artery ◽

Cardiac Rehabilitation ◽

Interval Training ◽

Patients With Diabetes ◽

Artery Disease

The study evaluated the influence of cardiac rehabilitation (CR) on heart rate variability (HRV) in men with coronary artery disease (CAD) with and without diabetes. Method: The study population included 141 male CAD patients prospectively and consecutively admitted to an outpatient comprehensive CR program. Twenty-seven patients with type-2 diabetes were compared with 114 males without diabetes. The participants performed a 45-min cycle ergometer interval training alternating 4-min workload and a 2-min active restitution three times a week for 8 weeks. The training intensity was adjusted so that the patient’s heart rate achieved the training heart rate calculated according to the Karvonen formula. At the baseline and after 8 weeks, all the patients underwent the HRV assessment. Results: HRV indices in the patients with diabetes were significantly lower as compared to the patients without diabetes in SDNN, TP, LF parameters, both at the baseline and after 8 weeks of CR. After 8 weeks of CR, a significant improvement of TP, SDNN, pNN50% and HF occurred in the patients without diabetes, whereas in the patients with diabetes only HF component improved significantly. Conclusions: As regards HRV indices, CR seems to be less effective in patients with CAD and type-2 diabetes.

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