Evaluation of the effects of a polyglycolic acid–collagen tube in the regeneration of facial nerve defects in rats

2018 ◽  
Vol 41 (10) ◽  
pp. 664-669 ◽  
Author(s):  
Miwako Oatari ◽  
Miyuki Uehara ◽  
Fumiaki Shimizu
Keyword(s):  
Facial Nerve ◽  
Nerve Regeneration ◽  
Functional Recovery ◽  
Wistar Rats ◽  
Polyglycolic Acid ◽  
Nerve Reconstruction ◽  
Facial Nerve Reconstruction

Purpose: The purpose of this study was to assess the utility of a polyglycolic acid–collagen tube and to investigate its possible application in the field of facial nerve reconstruction. Methods: Wistar rats were used in this study. In the operation, a periauricular incision was made to expose the buccal and marginal branches of the facial nerve. Gaps of 10 mm were created by resection of a part of the nerve into the marginal branches and the buccal branch of the left facial nerve. The left marginal branch gap was bridged with a 10-mm polyglycolic acid–collagen tube or an autograft. At 12 weeks after the operation, nerve regeneration was assessed based on clinical, histopathological, and electrophysiological evaluations. Result: The functional recovery of the vibrissal muscle was observed with the polyglycolic acid–collagen tube. However, the functional recovery obtained with the use of the polyglycolic acid–collagen tube was inferior to that obtained with an autograft. Conclusion: We found that polyglycolic acid–collagen tubes could be applied in facial nerve gap reconstruction. However, further improvements will be necessary to achieve results that are equivalent to those obtained with autografts.

A sural nerve “loop” graft for total facial nerve reconstruction: a clinical case

2021 ◽  
Vol 2 (2) ◽  
pp. 15-20
Author(s):  
V.A. Sukharev ◽  
◽  
S.V. Tereshchuk ◽  
E.A. Vasil’ev ◽  
◽  
...  
Keyword(s):  
Facial Expression ◽  
Facial Nerve ◽  
Functional Recovery ◽  
Sural Nerve ◽  
Clinical Case ◽  
Nerve Graft ◽  
Nerve Reconstruction ◽  
Original Technique ◽  
Facial Nerve Reconstruction ◽  
Sural Nerve Graft

In this article we present our experience in the reconstruction of multiple branches of the facial nerve by a loop of sural nerve graft on a patient with gigantic recurrent parotid adenoma. In the original technique of Kikabuchi et al., one end of the grafted nerve is sutured with the stumps of the facial nerve branches in an end-to-side manner through epineural windows made on the nerve graft. In contrast with this approach, we sutured the graft branches with the stumps of the facial nerve branches in an end-to-end manner. Functional recovery of all branches and satisfactory facial expression (House–Brackmann Grade I–II) were obtained within 2 years postoperatively. This technique is a useful option for facial nerve reconstruction managing multiple branches.

IMPACT OF DIFFERENT TYPES OF FACIAL NERVE RECONSTRUCTION ON THE RECOVERY OF MOTOR FUNCTION

Neurosurgery ◽  
2007 ◽  
Vol 61 (6) ◽  
pp. 1276-1285 ◽  
Author(s):  
Orlando Guntinas-Lichius ◽  
Gregor Hundeshagen ◽  
Thomas Paling ◽  
Doychin N. Angelov
Keyword(s):  
Facial Nerve ◽  
Functional Recovery ◽  
Nerve Repair ◽  
Angular Acceleration ◽  
Full Recovery ◽  
Fluorescence Labeling ◽  
Nerve Reconstruction ◽  
Adult Rats ◽  
Facial Nerve Reconstruction ◽  
Levator Labii Superioris

Abstract OBJECTIVE Poor functional recovery after facial nerve reconstruction is characterized by mass movements and synkinesis. Major reasons are axonal sprouting from the regenerating axons leading to misdirected reinnervation and hyperinnervation as well as polyinnervation of the mimic muscle end plates. We analyzed whether or not the type of nerve reconstruction influenced these pathological phenomena. METHODS The experiments were performed on 48 adult rats divided into four groups. One group served as an intact control and the experimental groups were subjected to facial-facial nerve repair (FFN), facial nerve interpositional grafting, and hypoglossal-facial nerve repair (HFN), with 12 subjects in each group. Two months later, functional recovery was measured by biometrical motion analysis of whisking. Retrograde fluorescence labeling of the brainstem motoneurons was used to quantify the degree of collateral axonal branching at the lesion site. Fluorescence histochemistry of sections through the levator labii superioris muscle was performed to quantify the degree of polyinnervation after surgery. RESULTS The type of nerve reconstruction significantly influenced the regeneration. The whisking amplitude did not recover completely regardless of the type of reconstruction. The angular velocity and angular acceleration of the vibrissal hairs showed a full recovery after facial nerve interpositional grafting and HFN, whereas these parameters remained decreased after FFN. Significantly less collateral branching and polyinnervation of the end plates were determined after grafting and HFN than after FFN. CONCLUSION No type of immediate facial nerve reconstruction results in a full recovery in the rat. However, the morphological and functional recovery was significantly better after grafting and HFN than after FFN.

Modular Bioactive Scaffold for Facial Nerve Reconstruction

2015 ◽  
Vol 76 (S 01) ◽  
Author(s):  
M. Röthlisberger ◽  
S. Madduri ◽  
S. Marbacher ◽  
D. Schaefer ◽  
D. Kalbermatten ◽  
...  
Keyword(s):  
Facial Nerve ◽  
Nerve Reconstruction ◽  
Facial Nerve Reconstruction

scholarly journals Facial Nerve Reconstruction with Free Vascularized Composite Nerve Flap from Intrapetrous Portion to Terminal Branches—Case Report

2021 ◽  
Author(s):  
Pedro C. Cavadas ◽  
Magdalena Baklinska
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Facial Nerve ◽  
Free Flap ◽  
Nerve Reconstruction ◽  
Nerve Stump ◽  
Stylomastoid Foramen ◽  
Facial Nerve Reconstruction ◽  
Delayed Reconstruction

AbstractThe case presented here is a delayed reconstruction of a facial nerve defect after radical parotidectomy without a useful nerve stump at the stylomastoid foramen. A composite free flap was used to reconnect the nerve’s intrapetrous portion to the peripheral branches and reconstruct the soft-tissue deficit.

Principles of Facial Nerve Reconstruction

Facial Palsy ◽  
2021 ◽  
pp. 55-69
Author(s):  
Andrés Rodríguez-Lorenzo ◽  
Chieh-Han John Tzou
Keyword(s):  
Facial Nerve ◽  
Nerve Reconstruction ◽  
Facial Nerve Reconstruction
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