The Syndrome of Inappropriate Secretion of Antidiuretic Hormone (Siadh): An Overview

1979 ◽  
Vol 24 (3) ◽  
pp. 225-231 ◽  
Author(s):  
C.J. Jose ◽  
S. Mehta ◽  
J. Perez-Cruet
Keyword(s):  
Antidiuretic Hormone ◽  
Mental Status ◽  
Psychiatric Patients ◽  
Hormone Secretion ◽  
Water Intoxication ◽  
Inappropriate Antidiuretic Hormone Secretion ◽  
Antidiuretic Hormone Secretion ◽  
Inappropriate Secretion

We have reviewed 14 cases of water intoxication in psychiatric patients. In these cases the possibility of the syndrome of inappropriate antidiuretic hormone secretion (SIADH) was suspected or diagnosed. The SIADH should be suspected in psychotic patients who drink water excessively, develop seizures, disorientation and deterioration of mental status.

Addison's Disease, Psychosis, and the Syndrome of Inappropriate Secretion of Antidiuretic Hormone

1983 ◽  
Vol 143 (4) ◽  
pp. 406-410 ◽  
Author(s):  
E. G. Lever ◽  
S. A. Stansfeld
Keyword(s):  
Antidiuretic Hormone ◽  
Psychological Symptoms ◽  
Hormone Secretion ◽  
Addison’S Disease ◽  
Addison's Disease ◽  
Inappropriate Antidiuretic Hormone Secretion ◽  
Diuretic Hormone ◽  
Antidiuretic Hormone Secretion ◽  
Inappropriate Secretion

SummaryA case of tuberculous Addison's disease presenting with psychosis, profound hyponatraemia, and detectable plasma antidiuretic hormone is reported. Clinical and biochemical improvement after corticosteroid replacement was followed by relapse with further psychosis and inappropriate antidiuretic hormone secretion: both were promptly reversed by demethylchlortetracycline. The association of psychological symptoms with Addison's disease, the role of anti-diuretic hormone secretion in Addison's disease, and the inter-relationship between Addison's disease, psychosis and anti-diuretic hormone secretion are discussed.

ESTIMATION OF ANTIDIURETIC HORMONE IN THE URINE OF HEALTHY SUBJECTS AND PATIENTS WITH INAPPROPRIATE SECRETION OF VASOPRESSIN (SCHWARTZ-BARTTER SYNDROME)

1967 ◽  
Vol 54 (1) ◽  
pp. 113-121 ◽  
Author(s):  
W. Ruch
Keyword(s):  
Antidiuretic Hormone ◽  
Healthy Subjects ◽  
Hormone Secretion ◽  
Normal Subjects ◽  
Bartter Syndrome ◽  
Ion Exchanger ◽  
Inappropriate Antidiuretic Hormone Secretion ◽  
Antidiuretic Hormone Secretion ◽  
Antidiuretic Activity ◽  
Inappropriate Secretion

ABSTRACT The excretion of antidiuretic hormone in the urine was determined in healthy subjects and patients with inappropriate secretion of vasopressin. The antidiuretic hormone was extracted by means of an ion exchanger and assayed in hydrated rats under alcohol anaesthesia. The urine of patients with inappropriate antidiuretic hormone secretion shows a higher antidiuretic activity than that of normal subjects.

scholarly journals Hiponatremia in the practice of a psychiatrist. Part 1: SIADH syndrome and drug-induced hyponatremia.

2017 ◽  
Vol 18 (2) ◽  
pp. 120-137
Author(s):  
Ewa Stelmach ◽  
Olga Hołownia ◽  
Maciej Słotwiński ◽  
Aneta Gerhant ◽  
Marcin Olajossy
Keyword(s):  
Antidiuretic Hormone ◽  
Psychotropic Drugs ◽  
Psychiatric Patients ◽  
Initial Period ◽  
Hormone Secretion ◽  
Psychiatric Practice ◽  
Common Mechanism ◽  
Drug Induced ◽  
Inappropriate Antidiuretic Hormone Secretion ◽  
Inappropriate Secretion

AbstractIntroduction. Hyponatremia is an important part of psychiatric practice. In order to analyze its causes and symptoms, the literature on hyponatremia in psychiatric patients has been reviewed. The work has been divided into two separate manuscripts. In the first one the authors discuss the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and hyponatremia occurring with the use of psychotropic drugs (antidepressants, antipsychotics, normotimics), while the second paper discusses research on psychogenic polydipsia. The causes of hyponatremia in patients treated in psychiatric wards include: water intoxication associated with polydipsia, somatic comorbidities, side effect of internal medicine and psychiatric drugs. The most common mechanism leading in these cases to hyponatremia is the syndrome of inappropriate secretion of vasopressin (SIADH). The SIADH syndrome is a group of symptoms, first described in 1967 by Schwartz and Bartter in The American Journal of Medicine, which results from the hypersecretion of antidiuretic hormone, also called vasopressin, which causes patients to develop normovolemic hyponatremia. The phenomenon of drug-induced hyponatremia in psychiatric practice is generally observed with the use of antidepressants, antipsychotics and anti-epileptic drugs (used in psychiatry as normotimic drugs).Aim and method. The first manuscript includes a review of literature on the syndrome of inappropriate secretion of vasopressin (SIADH) and hyponatremia occurring after the use of psychotropic drugs, and is divided into two subsections: 1. The syndrome of inappropriate secretion of vasopressin (SIADH), 2. Hyponatremia and psychotropic drugs (antidepressants, antipsychotics, normotimics).Conclusion. In the view of the reviewed literature it is extremely important to control the natremia level during pharmacotherapy using the above mentioned drugs, especially in the initial period of therapy.

scholarly journals Type D Syndrome of Inappropriate Antidiuretic Hormone Secretion in a Schizophrenia Patient with Polydipsia

2009 ◽  
Vol 1 ◽  
pp. JCNSD.S2330
Author(s):  
Takahira Yamauchi ◽  
Manabu Makinodan ◽  
Tomohisa Nagashima ◽  
Kuniaki Kiuchi ◽  
Yoshinobu Noriyama ◽  
...  
Keyword(s):  
Antidiuretic Hormone ◽  
Hypertonic Saline ◽  
Hormone Level ◽  
Schizophrenia Patient ◽  
Hormone Secretion ◽  
Water Intoxication ◽  
Water Loading ◽  
Inappropriate Antidiuretic Hormone Secretion ◽  
Antidiuretic Hormone Secretion ◽  
Type D

A 55-year-old man with schizophrenia developed water intoxication due to primary polydipsia. His manner of antidiuretic hormone secretion was investigated by water loading and infusion of hypertonic saline to clarify the form of the syndrome of inappropriate antidiuretic hormone secretion. The plasma antidiuretic hormone level, which may be involved in the occurrence of water intoxication, was consistently low in this patient, and linked to type D syndrome of inappropriate antidiuretic hormone secretion, designated “hypovasopressinemic antidiuresis”. Although this type is not common, it should be considered as a pathophysiology for water intoxication in schizophrenia patients.

Symptomatic Syndrome of Inappropriate Antidiuretic Hormone Secretion Associated with Azithromycin

1997 ◽  
Vol 31 (11) ◽  
pp. 1308-1310 ◽  
Author(s):  
Richard M Cadle ◽  
Rabih O Darouiche ◽  
Carol M Ashton
Keyword(s):  
Antidiuretic Hormone ◽  
Mental Status ◽  
Macrolide Antibiotic ◽  
Hormone Secretion ◽  
Data Sources ◽  
Severe Hyponatremia ◽  
Data Synthesis ◽  
Inappropriate Antidiuretic Hormone Secretion ◽  
Antidiuretic Hormone Secretion ◽  
Symptomatic Case

OBJECTIVE: To report a case of symptomatic syndrome of inappropriate antidiuretic hormone (SIADH) secretion associated with azithromycin and review the literature related to this adverse drug reaction. DATA SOURCES: Review articles identified by a computerized (MEDLINE) (1966–April 1996) and manual ( Index Medicus) search. DATA SYNTHESIS: Azithromycin is a well-tolerated broad-spectrum macrolide antibiotic. We report a symptomatic case of SIADH secretion associated with azithromycin. The patient received two doses of azithromycin before the development of sudden mental status changes associated with severe hyponatremia. All other potential causes were ruled out. No previous reports exist in the literature. CONCLUSIONS: Azithromycin may be associated with symptomatic SIADH secretion. Awareness and attention are required if patients develop mental status changes or hyponatremia while receiving azithromycin so that appropriate diagnostic and therapeutic actions can be implemented.

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