Symptomatic Syndrome of Inappropriate Antidiuretic Hormone Secretion Associated with Azithromycin

1997 ◽  
Vol 31 (11) ◽  
pp. 1308-1310 ◽  
Author(s):  
Richard M Cadle ◽  
Rabih O Darouiche ◽  
Carol M Ashton
Keyword(s):  
Antidiuretic Hormone ◽  
Mental Status ◽  
Macrolide Antibiotic ◽  
Hormone Secretion ◽  
Data Sources ◽  
Severe Hyponatremia ◽  
Data Synthesis ◽  
Inappropriate Antidiuretic Hormone Secretion ◽  
Antidiuretic Hormone Secretion ◽  
Symptomatic Case

OBJECTIVE: To report a case of symptomatic syndrome of inappropriate antidiuretic hormone (SIADH) secretion associated with azithromycin and review the literature related to this adverse drug reaction. DATA SOURCES: Review articles identified by a computerized (MEDLINE) (1966–April 1996) and manual ( Index Medicus) search. DATA SYNTHESIS: Azithromycin is a well-tolerated broad-spectrum macrolide antibiotic. We report a symptomatic case of SIADH secretion associated with azithromycin. The patient received two doses of azithromycin before the development of sudden mental status changes associated with severe hyponatremia. All other potential causes were ruled out. No previous reports exist in the literature. CONCLUSIONS: Azithromycin may be associated with symptomatic SIADH secretion. Awareness and attention are required if patients develop mental status changes or hyponatremia while receiving azithromycin so that appropriate diagnostic and therapeutic actions can be implemented.

Syndrome of Inappropriate Antidiuretic Hormone Secretion and Severe Hyponatremia Due to Pioglitazone

2010 ◽  
Vol 20 (6) ◽  
pp. 277-278 ◽  
Author(s):  
Aydin Unal ◽  
Ismail Kocyigit ◽  
Murat Hayri Sipahioglu ◽  
Bulent Tokgoz ◽  
Oktay Oymak ◽  
...  
Keyword(s):  
Antidiuretic Hormone ◽  
Hormone Secretion ◽  
Severe Hyponatremia ◽  
Inappropriate Antidiuretic Hormone Secretion ◽  
Antidiuretic Hormone Secretion

scholarly journals Urinary Retention and Severe Hyponatremia: An Unusual Presentation of COVID-19

2020 ◽  
Author(s):  
Ahmed Osman Saleh ◽  
Shaikha D. Al-Shokri ◽  
Ashraf Ahmed ◽  
Ahmed Elmustafa Musa ◽  
Mouhand FH Mohamed
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Urinary Retention ◽  
Antidiuretic Hormone ◽  
Hormone Secretion ◽  
Unusual Presentation ◽  
Respiratory Syndrome Virus ◽  
Unique Case ◽  
Severe Hyponatremia ◽  
Inappropriate Antidiuretic Hormone Secretion ◽  
Antidiuretic Hormone Secretion

Coronavirus disease 2019 (COVID-19) was first reported in Wuhan, China, in December 2019. The disease is caused by severe acute respiratory syndrome virus coronavirus 2 (SARS-CoV-2). A few published cases have linked COVID-19 and hyponatremia. The mechanism of hyponatremia in these cases is related to the syndrome of inappropriate antidiuretic hormone secretion (SIADH). Here we present a unique case of urinary retention and SIADH as unusual presenting features of SARS-CoV-2 infection.

Syndrome of Inappropriate Antidiuretic Hormone Secretion in a Cat

2010 ◽  
Vol 46 (6) ◽  
pp. 425-432 ◽  
Author(s):  
Kristin Cameron ◽  
Alexander Gallagher
Keyword(s):  
Antidiuretic Hormone ◽  
Hormone Secretion ◽  
Clinical Signs ◽  
Urine Osmolality ◽  
Electrolyte Imbalance ◽  
Fluid Restriction ◽  
Severe Hyponatremia ◽  
Inappropriate Antidiuretic Hormone Secretion ◽  
Antidiuretic Hormone Secretion ◽  
Serum And Urine

A 3-year-old, spayed female, domestic shorthaired cat was presented for evaluation of liver disease. Following anesthesia, laparoscopy, and medical therapy, the cat developed severe hyponatremia that was unresponsive to fluid therapy. Further evaluation of serum and urine osmolality determined that the cat fulfilled the criteria for syndrome of inappropriate antidiuretic hormone secretion. Treatment with fluid restriction resulted in resolution of the hyponatremia and clinical signs associated with the electrolyte imbalance.

Methyldopa-Induced Syndrome of Inappropriate Antidiuretic Hormone Secretion and Bone Marrow Granulomatosis

1988 ◽  
Vol 22 (9) ◽  
pp. 700-701 ◽  
Author(s):  
Yakov Varkel ◽  
Andrei Braester ◽  
David Nusem ◽  
Tamar Shkolnik
Keyword(s):  
Bone Marrow ◽  
Antidiuretic Hormone ◽  
Bone Marrow Biopsy ◽  
English Literature ◽  
Hormone Secretion ◽  
Severe Hyponatremia ◽  
Inappropriate Antidiuretic Hormone Secretion ◽  
Medline Search ◽  
Antidiuretic Hormone Secretion

A case of an elderly man who developed severe hyponatremia and bone marrow granulomatosis while taking methyldopa is described. The hyponatremia was found to be due to the syndrome of inappropriate antidiuretic hormone secretion (SIADH). Bone marrow biopsy revealed granulomas. A MEDLINE search of the English literature was done, yielding only one previous report of methyldopa-induced bone marrow granulomatosis and no previous reports of methyldopa-induced SIADH.

Syndrome of inappropriate antidiuretic hormone secretion in a cat with a putative Rathke’s cleft cyst

2014 ◽  
Vol 16 (12) ◽  
pp. 1010-1015 ◽  
Author(s):  
Stefanie M DeMonaco ◽  
Michael W Koch ◽  
Teresa L Southard
Keyword(s):  
Antidiuretic Hormone ◽  
Hormone Secretion ◽  
Systemic Hypertension ◽  
Rathke’S Cleft Cyst ◽  
Rathke's Cleft Cyst ◽  
Severe Hyponatremia ◽  
Inappropriate Antidiuretic Hormone Secretion ◽  
Antidiuretic Hormone Secretion ◽  
Peritoneal Effusion ◽  
Rathke's Cleft

An 11-year-old spayed female domestic shorthair cat was evaluated for anorexia, lethargy and weight loss of 6 days’ duration. Bilateral mydriasis, absent menace response, slow-to-absent pupillary light reflexes, bilateral retinal detachment, intermittent horizontal nystagmus, intermittent ventral strabismus and systemic hypertension were present. Biochemical analysis revealed severe hyponatremia, severe hypochloremia and mild hypokalemia. Multifocal central nervous system disease was suspected based on optic, trigeminal sensory (ophthalmic branch), vestibulocochlear and possible oculomotor nerve dysfunction. Thoracic radiographs showed mild cardiomegaly without evidence of congestive heart failure. Ultrasound revealed mild pleural and peritoneal effusion. A cause of the severe hyponatremia was not identified, and it persisted despite fluid therapy. Syndrome of inappropriate antidiuretic hormone secretion (SIADH) was suspected as the cause of hyponatremia. Humane euthanasia was elected owing to continued clinical decline. Serum hyposmolality, urine hyperosmolality, natriuresis and lack of confirmed renal, thyroid and pulmonary disease aided in the presumed diagnosis of SIADH. Post-mortem histopathology of the brain revealed degeneration of the hypothalamus and optic tracts, along with a prominent fluid-filled craniopharyngeal duct (putative Rathke’s cleft cyst) separating the pars distalis and the pars intermedius. The hypothalamic degeneration, possibly secondary to a Rathke’s cleft cyst, was hypothesized to be the cause of presumptive SIADH in the patient. Although rare in occurrence, Rathke’s cleft cyst should be included as a differential diagnosis in dogs and cats with signs of pituitary dysfunction.

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