Protocol on to Assess the Effectiveness of Planned Teaching on Knowledge Regarding to Adverse Effect of Antipsychotic Agents among Caregivers of Schizophrenia Patient

Background of the Study: The involvement of caregivers in treatment has been known as a vital part of mental health care. The enlarged emphasis on caregiver partaking has been to some extent driven by the shift from hospitals to primary provision of schizophrenia care in the community, where caregivers are more broadly involved in supporting consumers. Objectives: 1. To assess the pre-test knowledge regarding adverse effect of antipsychotic agent among caregivers of schizophrenia patients 2. To evaluate the effectiveness of planed teaching programme on knowledge regarding to antipsychotic agent among caregiver of schizophrenia patients. 3. To find out the association between post-test knowledge score with regards to adverse effect of antipsychotic agent regarding to adverse effect among caregivers of schizophrenia patients. Material and Methods: Pre-experimental, one group pretest and post-test design to assess the effectiveness of planed teaching on knowledge regarding adverse effect of antipsychotic agents and their response during the adverse effect among caregivers of schizophrenia patients. In this study total 100 caregivers of schizophrenia patient who full fill the inclusion criteria. Expected Results: This study is planned to assess the effectiveness of planed teaching on knowledge regarding to adverse effect of antipsychotic agents among caregivers of schizophrenia patients. There will be significant association between pre-test and post-test knowledge with regards to antipsychotic agents among schizophrenia patient’s caregivers. Conclusion: The conclusion will be drawn from the outcomes.

The Importance of Family Support in Successful Treatment Adherence of Schizophrenic Patient

Background: Schizophrenia is a treatable disease but requires patient’s high adherence to treatment. Family support of a schizophrenic patient plays an important role in encouraging the patient to continue his treatment. This report aims to enhance the importance of family support of schizophrenic patient in patient’s adherence to achieve a good mental health for all family member.Case: A hospitalized male paranoid schizophrenic patient who was admitted and observed in Dr. Soetomo General Hospital from September 15th-25th, 2020. Patient came to the hospital with chief complaint could not stop talking (rambling) since 1 day before admission. Patient could neither eat nor sleep for that day. Patient relapsed after stopping taking medication from the psychiatrist.Discussions: The patient in this case suffered a relapse of his paranoid schizophrenia because he stopped taking medication. Lack of support from family is the most important factor in a schizophrenia patient. Psychoeducation to patient’s family about schizophrenia and the importance of medication would be a great help for patient’s adherence to treatment.Conclusions: Schizophrenia needs a long-life treatment. High adherence to treatment could improve schizophrenia’s symptoms and prevent relapse. Family support is important to make sure the patient keeps taking his medicine regularly.

Reactivation of Latent Toxoplasmosis in a Schizophrenia Patient: A Case Report

Schizophrenia is a serious mental disorder characterized by chronic relapsing episodes of psychosis. The disease is multifactorial, where infections, genetic vulnerability and environmental factors are involved in the development of the illness. Toxoplasma gondii is one of the parasites that has long been known associated with schizophrenia in many studies. To date, there is growing evidence of association between T. gondii infections and schizophrenia. Herein we report a rare case of reactivated toxoplasmosis in a schizophrenia individual. This patient was incidentally diagnosed with reactivated T. gondii infection. He denied any symptoms of toxoplasmosis but experienced a mild psychiatric auditory hallucination. Serology test for T. gondii immunoglobulin antibodies measured a high positive IgG titer (135.9 IU/ml) and negative for IgM. Interestingly, nested PCR exhibited a positive result for the type I strain of T. gondii dense granular (GRA) 7 gene (GRA7). This case highlights the detection of probable reactivation of toxoplasmosis in an immunocompetent schizophrenic patient without psychiatric treatment-resistant and remains asymptomatic for toxoplasmosis. Both serology and molecular tools have been a helpful aid in establishing the diagnosis. Nonetheless, early detection as in this case may aid the patient management in the future.

Directional Persistence of Cell Migration in Schizophrenia Patient-Derived Olfactory Cells

Cell migration is critical for brain development and linked to several neurodevelopmental disorders, including schizophrenia. We have shown previously that cell migration is dysregulated in olfactory neural stem cells from people with schizophrenia. Although they moved faster than control cells on plastic substrates, patient cells were insensitive to regulation by extracellular matrix proteins, which increase the speeds of control cells. As well as speed, cell migration is also described by directional persistence, the straightness of movement. The aim of this study was to determine whether directional persistence is dysregulated in schizophrenia patient cells and whether it is modified on extracellular matrix proteins. Directional persistence in patient-derived and control-derived olfactory cells was quantified from automated live-cell imaging of migrating cells. On plastic substrates, patient cells were more persistent than control cells, with straighter trajectories and smaller turn angles. On most extracellular matrix proteins, persistence increased in patient and control cells in a concentration-dependent manner, but patient cells remained more persistent. Patient cells therefore have a subtle but complex phenotype in migration speed and persistence on most extracellular matrix protein substrates compared to control cells. If present in the developing brain, this could lead to altered brain development in schizophrenia.

The Role of the Family in Preventing Relapse of Schizophrenia Patient

BACKGROUND: The relapse rate of schizophrenia patients is still high. The family has an important role in helping schizophrenia patients to avoid recurrence. AIM: This study aimed to describe the role of the family in preventing relapse schizophrenia patients. METHODS: The research used a qualitative design with a phenomenology approach. The sample consisted of 12 families who had schizophrenic patients. The samples were obtained by purposive sampling technique. The data were collected by interview and using field notes, then analyzed by Colaizzi technique. RESULTS: The results showed that the role of the family in preventing the recurrence of schizophrenia patients was of four themes, namely, acceptance, assistance, hope, and communication from the family. CONCLUSION: There are four roles of the family to prevent a patient’s recurrence. The government needs to pay attention to the families of schizophrenia patients.

A unique missense variant in the E1A-binding protein P400 gene is implicated in schizophrenia by whole-exome sequencing and mutant mouse models

Genetic and epidemiological evidence has suggested that genetic factors are important in schizophrenia, although its pathophysiology is poorly understood. This study used whole-exome sequencing to investigate potential novel schizophrenia-causing genes in a Japanese family containing several members affected by severe or treatment-resistant schizophrenia. A missense variant, chr12:132064747C>T (rs200626129, P2805L), in the E1A-binding protein P400 (EP400) gene completely segregated with schizophrenia in this family. Furthermore, numerous other EP400 mutations were identified in the targeted sequencing of a schizophrenia patient cohort. We also created two lines of Ep400 gene-edited mice, which had anxiety-like behaviours and reduced axon diameters. Our findings suggest that rs200626129 in EP400 is likely to cause schizophrenia in this Japanese family, and may lead to a better understanding and treatment of schizophrenia.