Biological Markers in Borderline Personality Disorders: An Overview

1988 ◽  
Vol 33 (5) ◽  
pp. 350-354 ◽  
Author(s):  
Meir Steiner ◽  
Paul S. Links ◽  
Marilyn Korzekwa
Keyword(s):  
Mental Disorders ◽  
Personality Disorders ◽  
Biological Markers ◽  
Chronic Schizophrenia ◽  
Borderline Personality ◽  
Current Data ◽  
Axis Ii ◽  
Schizotypal Personality ◽  
Borderline Personality Disorders ◽  
Axis I

The state of knowledge in the area of suggested biological markers that may delineate subpopulations of patients with borderline personality disorders (BPD) is reviewed. There is widespread disagreement as to the specificity of these markers. The clinical implications of Axis I — Axis II, state vs. trait, acute vs. chronic, and definite vs. probable diagnoses, all seem to contribute to the confusion in this area. Some patients with BPD and with schizotypal personality disorders (SPD) share neuroendocrine abnormalities with affective disorders (AD) and schizophrenic (SCH)patients respectively. This interface and/or potential overlap between personality disorders (PD) and the major mental disorders is discussed with special reference to the DST, TRH/TSH test, and REM latency which have already been established as valuable biological markers for certain subtypes of depression. In contrast, biologic abnormalities observed in chronic schizophrenia are also present in some SPD patients. Current data are supportive of the hypothesis that some PD patients are independent whereas others are genetically related to the major mental disorders.

scholarly journals Diagnostic neglect: The potential impact of losing a separate axis for personality disorder

2015 ◽  
Vol 206 (5) ◽  
pp. 355-356 ◽  
Author(s):  
Giles Newton-Howes ◽  
Roger Mulder ◽  
Peter Tyrer
Keyword(s):  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Mental Disorders ◽  
Personality Disorders ◽  
Empirical Evidence ◽  
Borderline Personality ◽  
Axis Ii ◽  
Not Otherwise Specified ◽  
Potential Impact

SummaryBoth major classifications in psychiatry have now moved away from the multi-axial nosological model. This is clinically understandable as the specific categorical diagnoses, other than borderline personality disorder and personality disorder ‘NOS' (not otherwise specified) were so seldom used and empirical evidence would not support the polythetic categorical system. As a consequence, those with personality disorders, frequently referred to as Axis II disorders, now have to compete with all other mental disorders for clinical attention.

The relationship between reflective functioning and affect consciousness in patients with avoidant and borderline personality disorders.

2018 ◽  
Vol 35 (4) ◽  
pp. 382-393
Author(s):  
Merete S. Johansen ◽  
Sigmund W. Karterud ◽  
Eivind Normann-Eide ◽  
Frida G. Rø ◽  
Elfrida H. Kvarstein ◽  
...  
Keyword(s):  
Personality Disorders ◽  
Reflective Functioning ◽  
Borderline Personality ◽  
Borderline Personality Disorders ◽  
The Relationship

Borderline Symptom Inventory: Assessing Inpatient and Outpatient Borderline Personality Disorders

1988 ◽  
Vol 21 (1) ◽  
pp. 44-50 ◽  
Author(s):  
Lee S. Mann ◽  
Thomas N. Wise ◽  
Errol A. Segall ◽  
Richard L. Goldberg ◽  
David M. Goldstein
Keyword(s):  
Personality Disorders ◽  
Borderline Personality ◽  
Borderline Personality Disorders ◽  
Symptom Inventory

The dexamethasone suppression test and DSM-III-R diagnoses in suicide attempters

2003 ◽  
Vol 18 (7) ◽  
pp. 350-355 ◽  
Author(s):  
Åsa Westrin ◽  
Karin Frii ◽  
Lil Träskman-Bendz
Keyword(s):  
Personality Disorders ◽  
Stressful Events ◽  
Suicide Attempter ◽  
Axis Ii ◽  
Suppression Test ◽  
Axis I ◽  
Cortisol Levels ◽  
Low Cortisol ◽  
Hpa Axis Activity ◽  
Dexamethasone Suppression

AbstractPrevious research on hypothalamic-pituitary adrenal (HPA) axis-activity in suicide attempter research has shown conflicting outcomes. The design of the present study was to test the influence of personality disorders and concominant axis I diagnoses on the dexamethasone suppression diagnostic test by use of multiple regression analyses. The sample consisted of 184 patients with a recent suicide attempt and 42 healthy controls. As expected, the lowest pre- and postdexamethasone cortisol levels were found in patients with personality disorders axis II, cluster B as compared to the other patients. The results remained significant when analysed for covariance with DSM-III-R axis I diagnoses, age or sex. Whether these low cortisol levels are due to previous experience of extreme stressful events or long-lasting burden, or whether they may be a consequence of biogenetic or psychological predisposal of interest, remains to be elucidated. Axis I comorbidity needs to be further examined.

scholarly journals The genetic epidemiology of personality disorders

2010 ◽  
Vol 12 (1) ◽  
pp. 103-114 ◽  
Keyword(s):  
Personality Disorders ◽  
Genetic Factors ◽  
Association Studies ◽  
Molecular Genetic ◽  
Cluster Structure ◽  
Epidemiologic Studies ◽  
Axis Ii ◽  
Candidate Gene Association ◽  
Axis I ◽  
Dsm Iv

Genetic epidemiologic studies indicate that all ten personality disorders (PDs) classified on the DSM-IV axis II are modestly to moderately heritable. Shared environmental and nonadditive genetic factors are of minor or no importance. No sex differences have been identified, Multivariate studies suggest that the extensive comorbidity between the PDs can be explained by three common genetic and environmental risk factors. The genetic factors do not reflect the DSM-IV cluster structure, but rather: i) broad vulnerability to PD pathology or negative emotionality; ii) high impulsivity/low agreeableness; and iii) introversion. Common genetic and environmental liability factors contribute to comorbidity between pairs or clusters of axis I and axis II disorders. Molecular genetic studies of PDs, mostly candidate gene association studies, indicate that genes linked to neurotransmitter pathways, especially in the serotonergic and dopaminergic systems, are involved. Future studies, using newer methods like genome-wide association, might take advantage of the use of endophenotypes.

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