Long-term Mechanical Ventilation In Infants With Neuromuscular Disease

1988 ◽  
Vol 3 (1) ◽  
pp. 30-32 ◽  
Author(s):  
Susan T. Iannaccone ◽  
Timothy Guilfoile
Children ◽  
2021 ◽  
Vol 8 (6) ◽  
pp. 501
Author(s):  
Vineet Lamba ◽  
Oscar Winners ◽  
Prem Fort

The objective of the study is to determine if early high-dose caffeine (HD) therapy is associated with shorter duration of mechanical ventilation, bronchopulmonary dysplasia (BPD), or decreased need for mechanical ventilation. We conducted a single center, retrospective cohort study of 273 infants less than 32 weeks gestational age (GA). Infants receiving early HD (10 mg/kg/day maintenance) caffeine citrate started within 24 h of life were compared with those receiving LD (6 mg/kg/day) with variable timing of initiation using linear and logistic regression models. The infants in the early HD group had 91.4 (95% confidence interval (CI): −166.6, −16.1; p = 0.018) less hours of mechanical ventilation up to 36 weeks PMA or discharge as compared with the LD group. Moreover, infants in the HD group had 0.37 (95% CI: 0.14, 0.97; p = 0.042) times lower odds of developing moderate/severe BPD compared with the LD group. Infants receiving early HD caffeine had improved respiratory outcomes with no increase in measured comorbidities. Large prospective studies are needed to determine the long-term outcomes of using high-dose caffeine prophylaxis for preterm infants.


CHEST Journal ◽  
2007 ◽  
Vol 131 (1) ◽  
pp. 85-93 ◽  
Author(s):  
David J. Scheinhorn ◽  
Meg Stearn Hassenpflug ◽  
John J. Votto ◽  
David C. Chao ◽  
Scott K. Epstein ◽  
...  

1995 ◽  
Vol 23 (Supplement) ◽  
pp. A118
Author(s):  
Arthur Graves ◽  
Mark Scott ◽  
Gary Sporn ◽  
Mark Rumbak ◽  
Frank Walsh ◽  
...  

2010 ◽  
Vol 104 (5) ◽  
pp. 749-753 ◽  
Author(s):  
Santino Marchese ◽  
Antonio Corrado ◽  
Raffaele Scala ◽  
Salvatore Corrao ◽  
Nicolino Ambrosino

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