Poisoning severity score, Glasgow coma scale, corrected QT interval in acute organophosphate poisoning

The aim of this study was to investigate effectiveness of the poisoning severity score (PSS), Glasgow coma scale (GCS), and corrected QT (QTc) interval in predicting outcomes in acute organophosphates (OP) poisoning. Over a period of 2 years, 62 patients with OP poisoning were admitted to emergency department (ED) of Erciyes University Medical School Hospital. The age, sex, cause of contact, compound involved, time elapsed between exposure and admission to the ED, duration of hospital stay, and cardiac manifestations at the time of presentation were recorded. GCS and poisoning severity score (PSS) was calculated for each patient. Electrocardiogram (ECG) analysis included the rate, rhythm, ST-T abnormalities, conduction defects, and measurement of PR and QT intervals. Sixty-two patients with OP poisoning presented to our ED from January 2007 to December 2008 from which 54 patients were included in the study. The mean age was 34.1 ± 14.8 years. Of the cases, 53.7% were female. Twenty-six patients had a prolonged QTc interval. Mean PSS of men and women was 1.8 ± 1.0. No statistically significant correlation was found between the PSS and QTc intervals of the cases. A significant correlation was determined between the GCS and PSS of grade 3 and grade 4 cases. GCS is a parameter that helps clinician to identify advanced grade OP poisoning patients in the initial assessment in the ED. However, ECG findings, such as prolonged QTc interval, are not effective in determination of short-term prognosis and show no relationship with PSS.

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Organophosphate Poisoning: Prediction of Severity and Outcome by Glasgow Coma Scale, Poisoning Severity Score, Acute Physiology and Chronic Health Evaluation II Score, and Simplified Acute Physiology Score II

Journal of Emergency Nursing ◽

10.1016/j.jen.2012.05.021 ◽

2012 ◽

Vol 38 (5) ◽

pp. 493-495 ◽

Cited By ~ 8

Author(s):

Shobha Churi ◽

Krunal Bhakta ◽

Ramesh Madhan

Keyword(s):

Glasgow Coma Scale ◽

Severity Score ◽

Simplified Acute Physiology Score ◽

Acute Physiology Score ◽

Chronic Health Evaluation ◽

Organophosphate Poisoning ◽

Health Evaluation ◽

Chronic Health ◽

Coma Scale ◽

Poisoning Severity Score

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A study to assess the utility of poison severity score, pseudocholinesterase levels and Glasgow coma scale in predicting severity and clinical outcome of organophosphorus poisoning

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20210999 ◽

2021 ◽

Author(s):

Nitin Bhat ◽

Ramachandra Prabhu H. D. ◽

Adarsha Gopadi Krishna Bhat

Keyword(s):

Glasgow Coma Scale ◽

Severity Score ◽

Early Stage ◽

Research Centre ◽

Clinical Prognosis ◽

Coma Scale ◽

Organophosphorus Poisoning ◽

History Of ◽

Poisoning Severity Score ◽

A Prospective Study

Background: Suicides due to organophosphate self-poisoning is a major cause of concern world over. Organophosphate compounds (OP) possess a major cause of suicide in India. There is a greater need for tools to predict severity of OP poisoning. We in this study try to assess the utility of the Glasgow coma scale (GCS), pseudocholinesterase levels and the poisoning severity score (PSS) in estimating severity and clinical prognosis of OP poisoning in patients of south India.Methods: A prospective study was conducted over 2 years in department of medicine, KIMS hospital and research centre, patients who were >18 years of age were included. OP poisoning was determined by either history of consumption or clinical features. Pseudocholinesterase levels at admission, PPS and GCS scores were assessed at admission and at 24 hours. Clinical, demographical, and certain laboratory investigation were recorded. Patients were followed till the patient stayed in intensive care unit.Results: In present study 100 patients were enrolled. Significant association was observed between GCS (p<0.001), PSS (p<0.001) and outcome of OP poisoning. Unexpectedly no significant association was observed with pseudocholinesterase level (p=0.118). A total of 83% patients were improved after treatment and mortality rate observed was 17%. Out of these 83% severe complications were observed in 14% of the patients.Conclusions: The findings of this study highlight the usefulness of GCS and PSS systems for predicting severity of OP poisoning. Identification of severity at an early stage followed by prompt treatment can prevent deaths. Our study did not find any association between pseudocholinesterase levels at admission and severity of OP poisoning.

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