Flurbiprofen-induced generalized bullous fixed drug eruption

2013 ◽  
Vol 33 (1) ◽  
pp. 106-108 ◽  
Author(s):  
I Balta ◽  
H Simsek ◽  
GG Simsek
Keyword(s):  
Contact Dermatitis ◽  
Side Effect ◽  
Drug Eruption ◽  
Cutaneous Vasculitis ◽  
Fixed Drug Eruption ◽  
Fixed Drug ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Drug Related Side Effect ◽  
Erythematous Patch

Fixed drug eruption (FDE) is an unusual drug-related side effect that results in recurrent lesions whenever the causative drugs are used. FDEs usually occur as a single, sharply demarcated, round erythematous patch or plaque, occasionally with localized bullae. The most common offending agents include antimicrobials, nonsteroidal anti-inflammatory drugs, and antiepileptics. There are some reports where contact dermatitis and cutaneous vasculitis have been associated with the use of flurbiprofen. We present the case of a 50-year-old man with flurbiprofen-induced generalized bullous FDE. To the best of our knowledge, the most serious form of FDE, the generalized bullous FDE, to be caused by flurbiprofen has not been reported previously.

Nonsteroidal anti-inflammatory drugs-induced generalized fixed drug eruption: two cases

2011 ◽  
Vol 31 (2) ◽  
pp. 197-200 ◽  
Author(s):  
SG Bilgili ◽  
O Calka ◽  
AS Karadag ◽  
N Akdeniz ◽  
M Kosem
Keyword(s):  
Drug Eruption ◽  
Fixed Drug Eruption ◽  
Fixed Drug ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Fixed Drug Eruption Associated with Nonsteroidal Anti-Inflammatory Drugs for Menstrual Pain: A Case Report

2022 ◽  
pp. 6-11
Author(s):  
Risa Shimizu ◽  
Fumihiko Tsushima ◽  
Ruri Komiya ◽  
Yuko Yamagata ◽  
Hiroyuki Harada
Keyword(s):  
Drug Eruption ◽  
Repeated Administration ◽  
Menstrual Pain ◽  
Fixed Drug Eruption ◽  
Causative Drug ◽  
Fixed Drug ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Simplex Virus ◽  
Rule Out

Fixed drug eruption (FDE) is a type of drug reaction in which cutaneous or mucocutaneous lesions recur at the same site due to repeated administration of the causative drug. The most reported FDE-inducing drugs are nonsteroidal anti-inflammatory drugs (NSAIDs). We report a case of FDE associated with the use of NSAIDs for menstrual pain. A 33-year-old woman was referred to our department with blisters and soreness on her lips, tongue, and labial mucosa. The results of blood examination helped rule out herpes simplex virus infection, pemphigus, and pemphigoid. An FDE was suspected because these symptoms coincided with the use of NSAIDs for menstrual pain. Thus, the patient was advised not to use these NSAIDs but to use acetaminophen instead. No recurrence has been observed since the patient began avoiding these NSAIDs.

Topical Provocation in Fixed Drug Eruption from Nonsteroidal Anti-Inflammatory Drugs

2002 ◽  
Vol 1 (2) ◽  
pp. 81-86 ◽  
Author(s):  
Margarida Gonçalo ◽  
Hugo S. Oliveira ◽  
Bárbara Fernandes ◽  
Margarida Robalo-Cordeiro ◽  
Américo Figueiredo
Keyword(s):  
Drug Eruption ◽  
Fixed Drug Eruption ◽  
Fixed Drug ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Fixed drug eruption: A new side effect of bromelain

2020 ◽  
Vol 84 (1) ◽  
pp. 51-52
Author(s):  
Ömer Kutlu ◽  
Abdullah Demirbaş ◽  
Ömer F. Elmas ◽  
Ulaş Güvenç ◽  
Ahmet Metin
Keyword(s):  
Side Effect ◽  
Drug Eruption ◽  
Fixed Drug Eruption ◽  
Fixed Drug

Naproxen-induced fixed drug eruption: A case report

2011 ◽  
Vol 30 (11) ◽  
pp. 1872-1874 ◽  
Author(s):  
Hikmet Akyazi ◽  
Davut Baltaci ◽  
Sevdegul Mungan ◽  
Ismail Hamdi Kara
Keyword(s):  
Propionic Acid ◽  
Side Effect ◽  
Drug Eruption ◽  
Symptomatic Relief ◽  
Provocation Test ◽  
Cross Reactivity ◽  
Common Side Effect ◽  
Fixed Drug Eruption ◽  
Fixed Drug ◽  
Oral Provocation Test

Naproxen is a non-steroidal anti-inflammatory drug (NSAID) widely used for symptomatic relief of arthritis and other painful disorders, such as dysmenorrheal. Pruritus is the most common side effect of naproxen. Fixed drug eruption (FDE) due to naproxen is a rarely reported side-effect. No previous report has declared cross-reactivity between naproxen and other propionic acid derivatives. A 28-year-old man, presented with edematous and erythematous patchy lesion along with pruritus and inflammation on lip, have been suffering since 3 hours. It started after taking naproxen 550 mg for headache. On detailed inquiry, he defined similar symptom which recurred after whenever he took naproxen. Based on clinical and histopathological findings, it is evaluated as naproxen-induced FDE. We have tested cross-reactivity between naproxen and other propionic acid derivatives, and then we obtained negative result for oral provocation test with flurbiprofen. Here, we present a case of naproxen-induced FDE of 28-year-old man, by overviewing literatures.

scholarly journals Ofloxacin/ tinidazole induced fixed drug eruption- a case report

2021 ◽  
Vol 2 (1) ◽  
pp. 36-38
Author(s):  
Monika Kapoor
Keyword(s):  
Adverse Drug Reaction ◽  
Case Report ◽  
Drug Eruption ◽  
Fixed Drug Eruption ◽  
Drug Induced ◽  
Drug Eruptions ◽  
Fixed Drug ◽  
Causative Agents ◽  
Inflammatory Drugs ◽  
Cutaneous Adverse Drug Reaction

Introduction: An immunological cutaneous adverse drug reaction is distinguished as sharply defined lesions with red rashes and sharp borders, erythematous lesions with or without blisters developing within an hour or in a few cases within a week after drug administration is termed as fixed drug eruptions (FDE). FDE is one of the major forms of drug-induced dermatosis. Various class of drugs that are causative agents for FDE includes antibiotics, anticonvulsants, antivirals, and Non-steroidal anti-inflammatory drugs (NSAID). FDE is easily recognized and differentiated from other drug eruptions since it does not occur voluntarily or during infection. Case report: This case report is to spotlight the case of a 52-year-old male patient who was undergoing treatment for acute gastroenteritis and suffered from FDE due to administration of IV Ofloxacin.

Fixed drug eruption: a novel side-effect of levocetirizine

2005 ◽  
Vol 44 (9) ◽  
pp. 796-798 ◽  
Author(s):  
Vikram K. Mahajan ◽  
Nand Lal Sharma ◽  
Vikas C. Sharma
Keyword(s):  
Side Effect ◽  
Drug Eruption ◽  
Fixed Drug Eruption ◽  
Fixed Drug
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