scholarly journals Ofloxacin/ tinidazole induced fixed drug eruption- a case report

2021 ◽  
Vol 2 (1) ◽  
pp. 36-38
Author(s):  
Monika Kapoor
Keyword(s):  
Adverse Drug Reaction ◽  
Case Report ◽  
Drug Eruption ◽  
Fixed Drug Eruption ◽  
Drug Induced ◽  
Drug Eruptions ◽  
Fixed Drug ◽  
Causative Agents ◽  
Inflammatory Drugs ◽  
Cutaneous Adverse Drug Reaction

Introduction: An immunological cutaneous adverse drug reaction is distinguished as sharply defined lesions with red rashes and sharp borders, erythematous lesions with or without blisters developing within an hour or in a few cases within a week after drug administration is termed as fixed drug eruptions (FDE). FDE is one of the major forms of drug-induced dermatosis. Various class of drugs that are causative agents for FDE includes antibiotics, anticonvulsants, antivirals, and Non-steroidal anti-inflammatory drugs (NSAID). FDE is easily recognized and differentiated from other drug eruptions since it does not occur voluntarily or during infection. Case report: This case report is to spotlight the case of a 52-year-old male patient who was undergoing treatment for acute gastroenteritis and suffered from FDE due to administration of IV Ofloxacin.

scholarly journals Fixed drug eruption associated with fixed combination of fluoroquinolone-nitroimidazole

2021 ◽  
Vol 10 (5) ◽  
pp. 576
Author(s):  
R. Meenakshi ◽  
S. Nitya ◽  
S. Kiruthika ◽  
M. Shanthi
Keyword(s):  
Adverse Drug Reaction ◽  
Adverse Reaction ◽  
Drug Eruption ◽  
Fixed Combination ◽  
Fixed Drug Eruption ◽  
Combination Drug ◽  
Drug Eruptions ◽  
Fixed Drug ◽  
Erythematous Plaques ◽  
Cutaneous Adverse Drug Reaction

Fixed drug eruptions (FDE) are cutaneous adverse drug reaction characterized by well demarcated erythematous plaques which on removal of the offending agent resolves with residual hyperpigmentation patches at the site. FDE to nitroimidazoles and fluoroquinolones have nevertheless been infrequently reported. Awareness about the adverse reaction to the fluoroquinolone-nitroimidazole combination drug and also the likelihood of recurrence with same or similar drugs and the possible cross reaction is eminent. Hereby we report one such case of FDE to ciprofloxacin/tinidazole combination.

scholarly journals Fixed drug eruption caused by tadalafil - case report

2013 ◽  
Vol 88 (4) ◽  
pp. 617-619 ◽  
Author(s):  
Milan Bjekic ◽  
Milica Markovic ◽  
Sandra Sipetic
Keyword(s):  
Case Report ◽  
Complete Resolution ◽  
Drug Eruption ◽  
Personal History ◽  
Oral Lesions ◽  
Fixed Drug Eruption ◽  
Drug Eruptions ◽  
Short Course ◽  
Fixed Drug ◽  
Recreational Use

Fixed drug eruptions (FDE) are commonly reported type of mucocutaneous drug eruption. The aim of this paper is to present a patient with multiple mucocutaneous erythema fixum type lesions caused by oral tadalafil use. A short course of topical corticosteroid therapy resulted in complete resolution of all lesions leaving residual hyperpigmentation of the involved skin sites. Mucosal oral lesions were effectively treated with gingival hyaluronic acid 0.2% gel. Conclusion: when assessing a patient of any age with drug eruptions, a thorough personal history should be obtained, in particular data on regular or recreational use of phospodiesterase type 5 inhibitors.

scholarly journals Severe Generalized Bullous Fixed Drug Eruption Treated with Cyclosporine: A Case Report and Literature Review

2021 ◽  
pp. 154-163
Author(s):  
Hailey C. Barootes ◽  
Erin R. Peebles ◽  
Doreen Matsui ◽  
Michael Rieder ◽  
Awatif Abuzgaia ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Cyclosporine A ◽  
Drug Eruption ◽  
Paediatric Population ◽  
Fixed Drug Eruption ◽  
Drug Eruptions ◽  
Fixed Drug ◽  
Paediatric Case ◽  
Oral Ibuprofen

Generalized bullous fixed drug eruptions (GBFDEs) are rare in the paediatric population. We present the case of a 7-year-old girl with GBFDE believed to be secondary to oral ibuprofen, who experienced rapid resolution of lesions and cessation of blistering with a 3-week course of oral cyclosporine. To the best of our knowledge, this is the first report of a paediatric case of GBFDE treated with cyclosporine. In our report, we review published cases of GBFDE in children, and all adult cases managed with cyclosporine.

scholarly journals A case of self-treatment induced oral mucosal fixed drug eruptions associated with use of tinidazole - a case report

2021 ◽  
Vol 9 (6) ◽  
pp. 1794
Author(s):  
Swathi C. Prabhu ◽  
Harshavardhan K. Shetty
Keyword(s):  
Adverse Reaction ◽  
Case Report ◽  
Oral Mucosa ◽  
Medical Practice ◽  
Drug Eruption ◽  
Case Reports ◽  
Common Site ◽  
Fixed Drug Eruption ◽  
Drug Eruptions ◽  
Fixed Drug

Fixed drug eruptions (FDE) is a type of adverse reaction to drugs encountered in medical practice. Skin, glans penis is most common site of involvement. We hereby report a case of fixed drug eruption on oral mucosa due to tinidazole, a nitroimidazole-derivative which the patient had taken as he was suffering from gastro-intestinal distress. Very limited case reports have been found in literature with respect to tinidazole causing FDE.

Norfloxacin Induced Recurrent Fixed Drug Eruption in a self Treated Adult Female Patient - A Case Report

2019 ◽  
Vol 14 (1) ◽  
pp. 72-76 ◽  
Author(s):  
Singh Vikramjeet ◽  
Batta Angelika ◽  
Malik Nishtha
Keyword(s):  
Case Report ◽  
Drug Eruption ◽  
Causality Assessment ◽  
Young Female ◽  
Fixed Drug Eruption ◽  
Gastrointestinal Infections ◽  
Fixed Drug ◽  
Cutaneous Adverse Drug Reaction ◽  
Similar Episode ◽  
Adult Female Patient

Background: Fixed drug eruption is a clinical entity occurring at the same site each time the drug is administered. They are usually found on lips, genitalia, abdomen, and legs but can occur at any location. The eruptions usually occur within hours of administration of the drug and resolves spontaneously. Most common drugs causing them include antimicrobials. Fluroquinolones especially norfloxacin is commonly used in the treatment of gastrointestinal infections. Cutaneous adverse drug reactions are very rare with norfloxacin. Case Report: In this case report, a young female, soon after taking Nofloxacin tablet, developed a blister with erythema and itching after self treatment for urinary tract infection. It got cured after stopping the drug and taking treatment from a dermatologist. It resolved as a hyper-pigmented scar. She experienced a similar episode of drug eruption on the same site when she again self medicated herself with Norfloxacin for diarrhoea. This time the reaction occurred within few hours and resolved with hyperpigmentation after medication. She was advised not to indulge in self-treatment in future. Suspecting association between the drug and the rash was confirmed and a diagnosis of Norfloxacin induced fixed drug eruption was made. Conclusion: Causality assessment by Naranjo’s algorithm revealed a definite relationship between the cutaneous adverse drug reaction and the offending drug.

scholarly journals A clinical study of morphological patterns of cutaneous adverse drug reaction and its causality assessment in tertiary care hospital of central India

2020 ◽  
Vol 9 (10) ◽  
pp. 1528
Author(s):  
Tanaji R. Shende ◽  
Riyaz A. Siddiqui
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Adverse Drug Reactions ◽  
Drug Eruption ◽  
Causality Assessment ◽  
Age Group ◽  
Drug Reactions ◽  
Fixed Drug Eruption ◽  
Fixed Drug ◽  
Cutaneous Adverse Drug Reaction

Background: Adverse reactions to drugs are as old as drug. Cutaneous adverse drug reactions are the most common type of drug reaction. Most cutaneous adverse drug reactions are important as they are frequently the reason for discontinuation of drug therapy. Looking to this matter the study was undertaken.Method: It was an observational study conducted at NKP Salve Institute of Medical Science & Research Centre, Nagpur Maharashtra. A total number of 80 patients having cutaneous adverse drug reaction were evaluated. All the patients were assessed for cutaneous adverse drug reaction during the study period and the information was carefully recorded in standard Adverse drug reaction (ADR) form and Naranjo’s algorithm was used for causality assessment of adverse drug reaction.Result: The maximum study subjects were in the age group of 41-50 years (32-50%) followed by the age group of 31-40 years (25%) followed by other age groups. In study group male to female ratio was 11.5:8.5. Majority of cutaneous adverse drug reactions comprise of fixed drug eruption which is 45%. Most of the cutaneous ADR’s were caused by antibiotics (42.5%) followed by Non-steroidal anti-inflammatory drugs (NSAIDS) (20%). The study subjects were in probable causality assessment of Naranjo’s scale i.e. 82.5% followed by definite in (12.5%) and possible (5%).Conclusion: The fixed drug eruption was the most common cutaneous adverse drug reaction and most of these drugs eruptions were caused by antimicrobial agents. The study provided the base line information about the prevalence of cutaneous adverse drug reaction and their morphological distribution amongst different age group, gender and the causative drug.

A Case Report of Tadalafil-Associated Fixed Drug Eruption

2017 ◽  
Vol 31 (6) ◽  
pp. 678-681 ◽  
Author(s):  
Ada W. Chiu ◽  
Robert Stenstrom
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Case Report ◽  
Drug Eruption ◽  
Case Reports ◽  
Good Evidence ◽  
Medical Attention ◽  
Medication History ◽  
Fixed Drug Eruption ◽  
Fixed Drug

Tadalafil is a drug approved for use in erectile dysfunction, but increasingly being used recreationally. There have only been scant case reports on tadalafil causing fixed drug eruption (FDE). Patients who use tadalafil recreationally are less likely to seek medical attention and the diagnosis can often be missed, given the difficulty in diagnosis. However, clinical examination together with a detailed medication history can provide clinicians with good evidence of the association without invasive biopsies. We discuss a 37-year-old male who developed FDE after 2 separate exposures to tadalafil used for recreational purpose. The scar from the first reaction served as a landmark for the second exposure. His lesions resolved 2 days after the initial presentation. The Naranjo adverse drug reaction probability scale (score = 9) indicates a definite adverse drug reaction to tadalafil. We hope to raise awareness of this drug reaction with this case report.

Phenolphthalein-Induced Fixed Drug Eruption: A Cutaneous Complication of Laxative Use in a Child

PEDIATRICS ◽  
1993 ◽  
Vol 91 (6) ◽  
pp. 1199-1201
Author(s):  
MICHAEL D. ZANOLLI ◽  
JOANNE MCALVANY ◽  
DANIEL P. KROWCHUK
Keyword(s):  
African American ◽  
Case Report ◽  
Drug Eruption ◽  
Fixed Drug Eruption ◽  
American Girl ◽  
Laxative Use ◽  
Dermatology Clinic ◽  
Drug Eruptions ◽  
Fixed Drug ◽  
African American Girl

Drug eruptions are a common dermatologic problem faced by pediatricians. Among the most distinctive of these is the fixed drug eruption, a cutaneous inflammatory reaction manifested by solitary or multiple, well-defined, erythematous macules that may become bullous.1,2 Lesions usually occur within a few hours of ingesting the drug, characteristically recur in the same location with each subsequent dose, and leave residual hyperpigmentation. To illustrate the importance and unique features of this unusual reaction, we report the case of a child who experienced a recurrent fixed drug eruption induced by phenolphthalein-containing, nonprescription laxatives. CASE REPORT An 8-year-old African-American girl was brought to the Dermatology Clinic for evaluation of pruritic and occasionally swollen "dark spots" that had been present on her face and arms for months.

scholarly journals Antituberculosis Drug-Induced Fixed Drug Eruption: A Case Report

2018 ◽  
Vol 5 (1) ◽  
Author(s):  
Jitendra H. Vaghela ◽  
Vivek Nimbark ◽  
Manish Barvaliya ◽  
Hita Mehta ◽  
Bhavesh Chavada
Keyword(s):  
Case Report ◽  
Drug Eruption ◽  
Antituberculosis Drug ◽  
Fixed Drug Eruption ◽  
Drug Induced ◽  
Fixed Drug
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