scholarly journals Fixed Drug Eruption Associated with Nonsteroidal Anti-Inflammatory Drugs for Menstrual Pain: A Case Report

2022 ◽  
pp. 6-11
Author(s):  
Risa Shimizu ◽  
Fumihiko Tsushima ◽  
Ruri Komiya ◽  
Yuko Yamagata ◽  
Hiroyuki Harada
Keyword(s):  
Drug Eruption ◽  
Repeated Administration ◽  
Menstrual Pain ◽  
Fixed Drug Eruption ◽  
Causative Drug ◽  
Fixed Drug ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Simplex Virus ◽  
Rule Out

Fixed drug eruption (FDE) is a type of drug reaction in which cutaneous or mucocutaneous lesions recur at the same site due to repeated administration of the causative drug. The most reported FDE-inducing drugs are nonsteroidal anti-inflammatory drugs (NSAIDs). We report a case of FDE associated with the use of NSAIDs for menstrual pain. A 33-year-old woman was referred to our department with blisters and soreness on her lips, tongue, and labial mucosa. The results of blood examination helped rule out herpes simplex virus infection, pemphigus, and pemphigoid. An FDE was suspected because these symptoms coincided with the use of NSAIDs for menstrual pain. Thus, the patient was advised not to use these NSAIDs but to use acetaminophen instead. No recurrence has been observed since the patient began avoiding these NSAIDs.

Nonsteroidal anti-inflammatory drugs-induced generalized fixed drug eruption: two cases

2011 ◽  
Vol 31 (2) ◽  
pp. 197-200 ◽  
Author(s):  
SG Bilgili ◽  
O Calka ◽  
AS Karadag ◽  
N Akdeniz ◽  
M Kosem
Keyword(s):  
Drug Eruption ◽  
Fixed Drug Eruption ◽  
Fixed Drug ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Flurbiprofen-induced generalized bullous fixed drug eruption

2013 ◽  
Vol 33 (1) ◽  
pp. 106-108 ◽  
Author(s):  
I Balta ◽  
H Simsek ◽  
GG Simsek
Keyword(s):  
Contact Dermatitis ◽  
Side Effect ◽  
Drug Eruption ◽  
Cutaneous Vasculitis ◽  
Fixed Drug Eruption ◽  
Fixed Drug ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Drug Related Side Effect ◽  
Erythematous Patch

Fixed drug eruption (FDE) is an unusual drug-related side effect that results in recurrent lesions whenever the causative drugs are used. FDEs usually occur as a single, sharply demarcated, round erythematous patch or plaque, occasionally with localized bullae. The most common offending agents include antimicrobials, nonsteroidal anti-inflammatory drugs, and antiepileptics. There are some reports where contact dermatitis and cutaneous vasculitis have been associated with the use of flurbiprofen. We present the case of a 50-year-old man with flurbiprofen-induced generalized bullous FDE. To the best of our knowledge, the most serious form of FDE, the generalized bullous FDE, to be caused by flurbiprofen has not been reported previously.

Topical Provocation in Fixed Drug Eruption from Nonsteroidal Anti-Inflammatory Drugs

2002 ◽  
Vol 1 (2) ◽  
pp. 81-86 ◽  
Author(s):  
Margarida Gonçalo ◽  
Hugo S. Oliveira ◽  
Bárbara Fernandes ◽  
Margarida Robalo-Cordeiro ◽  
Américo Figueiredo
Keyword(s):  
Drug Eruption ◽  
Fixed Drug Eruption ◽  
Fixed Drug ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Doxycycline induced fixed drug eruption: a case report

2018 ◽  
Vol 7 (11) ◽  
pp. 2264
Author(s):  
Isswariya Anandan ◽  
Nitya Selvaraj ◽  
Suganya Ganesan ◽  
Meher Ali Rajamohammad ◽  
Nalinidevi Jayabalan
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Drug Eruption ◽  
Skin Lesions ◽  
Severity Assessment ◽  
Fixed Drug Eruption ◽  
Skin Reactions ◽  
Dermatological Examination ◽  
Causative Drug ◽  
Fixed Drug

Fixed drug eruption (FDE) is an adverse drug reaction seen with various groups of drugs are antibiotics such as trimethoprim -sulphamethoxazle, pencillin, tetracyclines, non steroidal anti- inflammatory drugs like ibuprofen, aspirin etc. Doxycycline belongs to tetracycline groups of antibiotics. We herein present the case of Doxycycline induced fixed drug eruption. A 35-year - old man presented to our hospital, with a 2-day history of itching and hyperpigmentation over the chest. Patient developed skin lesion 2 days after and he started taking Doxycycline 100 mg twice a day for skin infections. Dermatological examination revealed multiple well defined hyperpigmented patches seen over the anterior aspect of the chest. Doxycycline was discontinued immediately, and the skin lesions resolved spontaneously within 2 weeks. Causality assessment by using Naranjo adverse drug reaction probability scale and WHO Uppsala monitoring scale categorize the reaction as Doxycycline was the probable cause for the adverse drug reaction. Severity assessment by using modified Hartwig and Siegel ADR severity assessment scale labelled the reaction as mild-level 2. The causative drug or drugs and cross reactants should be avoided in future to prevent recurrence of similar skin reactions.

scholarly journals Clinical Features and Drug Characteristics of Patients with Generalized Fixed Drug Eruption in the West of Iran (2005–2014)

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Hossein Kavoussi ◽  
Mansour Rezaei ◽  
Katayoun Derakhshandeh ◽  
Alireza Moradi ◽  
Ali Ebrahimi ◽  
...  
Keyword(s):  
Clinical Features ◽  
Drug Eruption ◽  
Cross Sectional Study ◽  
Fixed Drug Eruption ◽  
The West ◽  
Cross Sectional ◽  
Drug Eruptions ◽  
Causative Drug ◽  
Fixed Drug ◽  
Antibiotic Group

Background.Generalized fixed drug eruption is a specific variant of fixed drug eruption with multifocal lesions. Diagnosis of this drug reaction is straightforward, but occasionally recognition of the causative drug is not possible. This study was aimed at evaluating the clinical features and culprit drugs in generalized fixed drug eruptions in the west of Iran.Method.This cross-sectional study was carried out on 30 patients with criteria of generalized fixed drug eruption over 9 years. Demographic, clinical, and drug intake information were collected.Results.Out of 30 patients (17 females and 13 males) with the mean age of26.67±10.21years, 28 (93.3%) and 2 (6.7%) cases had plaque and bullous clinical presentation, respectively. Upper limbs were the most common (90%) site of involvement. The antibiotic group, especially cotrimoxazole (26.1%), was reported to be the most common offending drug, but the causative drug was not determined in 7 (23.3%) patients.Conclusion.Many cases of generalized fixed drug eruption firstly presented as limited lesions and led to generalized lesion due to repeated intake of the causative drug. No causative drug was found in some patients, which might be associated with concurrent intake of several drugs, multiple FDE, and peculiarity of the patch test.

scholarly journals Ofloxacin/ tinidazole induced fixed drug eruption- a case report

2021 ◽  
Vol 2 (1) ◽  
pp. 36-38
Author(s):  
Monika Kapoor
Keyword(s):  
Adverse Drug Reaction ◽  
Case Report ◽  
Drug Eruption ◽  
Fixed Drug Eruption ◽  
Drug Induced ◽  
Drug Eruptions ◽  
Fixed Drug ◽  
Causative Agents ◽  
Inflammatory Drugs ◽  
Cutaneous Adverse Drug Reaction

Introduction: An immunological cutaneous adverse drug reaction is distinguished as sharply defined lesions with red rashes and sharp borders, erythematous lesions with or without blisters developing within an hour or in a few cases within a week after drug administration is termed as fixed drug eruptions (FDE). FDE is one of the major forms of drug-induced dermatosis. Various class of drugs that are causative agents for FDE includes antibiotics, anticonvulsants, antivirals, and Non-steroidal anti-inflammatory drugs (NSAID). FDE is easily recognized and differentiated from other drug eruptions since it does not occur voluntarily or during infection. Case report: This case report is to spotlight the case of a 52-year-old male patient who was undergoing treatment for acute gastroenteritis and suffered from FDE due to administration of IV Ofloxacin.

scholarly journals A Review of Fixed Drug Eruption with a Special Focus on Generalized Bullous Fixed Drug Eruption

Medicina ◽  
2021 ◽  
Vol 57 (9) ◽  
pp. 925
Author(s):  
Hannah J. Anderson ◽  
Jason B. Lee
Keyword(s):  
Drug Eruption ◽  
The Body ◽  
Stevens Johnson Syndrome ◽  
Special Focus ◽  
Fixed Drug Eruption ◽  
Causative Drug ◽  
Johnson Syndrome ◽  
Fixed Drug ◽  
Specific Medication ◽  
Cutaneous Adverse Drug Reaction

Fixed drug eruption (FDE) is a cutaneous adverse drug reaction characterized by the onset of rash at a fixed location on the body each time a specific medication is ingested. With each recurrence, the eruption can involve additional sites. Lesions can have overlying vesicles and/or bullae, and when they cover a significant percentage of body surface area, the eruption is referred to as generalized bullous fixed drug eruption (GBFDE). Due to the widespread skin denudation that can be seen in this condition, GBFDE may be confused clinically with Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). While treatments described for GBFDE include supportive care, topical and/or systemic steroids, and, recently, cyclosporine, the mainstay of management involves identifying and discontinuing the causative drug. This review article will provide an overview of FDE with an emphasis on its generalized bullous variant.

scholarly journals Bullous fixed drug eruption following administration of the recombinant adjuvant Shingrix vaccine

2021 ◽  
Vol 14 (8) ◽  
pp. e241293
Author(s):  
Hallie Thompson ◽  
Laura Nichols ◽  
Tania Gonzalez Santiago
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Varicella Zoster Virus ◽  
Drug Eruption ◽  
Oral Prednisone ◽  
Punch Biopsy ◽  
Fixed Drug Eruption ◽  
Varicella Zoster ◽  
Fixed Drug ◽  
Simplex Virus

A 51-year-old woman with Crohn’s disease presented with a bullous rash on her left arm and axilla 2 days after receiving her second dose of the recombinant adjuvant Shingrix vaccine. PCR for herpes simplex virus (HSV) 1, HSV 2 and varicella zoster virus was negative. Punch biopsy revealed changes that were consistent with a bullous fixed drug eruption. She was successfully treated oral prednisone and topical triamcinolone cream. This is the first known case of a bullous fixed drug eruption due to the recombinant adjuvant Shingrix vaccine.

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