Faculty Opinions recommendation of Occupationally induced fixed drug eruption caused by a non-steroidal anti-inflammatory agent.

Fixed drug eruption (FDE) is a type of drug reaction in which cutaneous or mucocutaneous lesions recur at the same site due to repeated administration of the causative drug. The most reported FDE-inducing drugs are nonsteroidal anti-inflammatory drugs (NSAIDs). We report a case of FDE associated with the use of NSAIDs for menstrual pain. A 33-year-old woman was referred to our department with blisters and soreness on her lips, tongue, and labial mucosa. The results of blood examination helped rule out herpes simplex virus infection, pemphigus, and pemphigoid. An FDE was suspected because these symptoms coincided with the use of NSAIDs for menstrual pain. Thus, the patient was advised not to use these NSAIDs but to use acetaminophen instead. No recurrence has been observed since the patient began avoiding these NSAIDs.

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Non-pigmenting fixed drug eruption caused by an over-the-counter non-steroidal anti-inflammatory drug: Drug-specific CD8+ T lymphocytes identified in peripheral blood

European Journal of Dermatology ◽

10.1684/ejd.2012.1793 ◽

2012 ◽

Vol 22 (5) ◽

pp. 680-682 ◽

Cited By ~ 2

Author(s):

Takaaki Hanafusa ◽

Hiroaki Azukizawa ◽

Sayaka Matsumura ◽

Yukako Murakami ◽

Aya Tanaka ◽

...

Keyword(s):

T Lymphocytes ◽

Peripheral Blood ◽

Drug Eruption ◽

Fixed Drug Eruption ◽

Over The Counter ◽

Inflammatory Drug ◽

Cd8 T Lymphocytes ◽

Fixed Drug ◽

Anti Inflammatory

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Flurbiprofen-induced generalized bullous fixed drug eruption

Human & Experimental Toxicology ◽

10.1177/0960327113489048 ◽

2013 ◽

Vol 33 (1) ◽

pp. 106-108 ◽

Cited By ~ 1

Author(s):

I Balta ◽

H Simsek ◽

GG Simsek

Keyword(s):

Contact Dermatitis ◽

Side Effect ◽

Drug Eruption ◽

Cutaneous Vasculitis ◽

Fixed Drug Eruption ◽

Fixed Drug ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Drug Related Side Effect ◽

Erythematous Patch

Fixed drug eruption (FDE) is an unusual drug-related side effect that results in recurrent lesions whenever the causative drugs are used. FDEs usually occur as a single, sharply demarcated, round erythematous patch or plaque, occasionally with localized bullae. The most common offending agents include antimicrobials, nonsteroidal anti-inflammatory drugs, and antiepileptics. There are some reports where contact dermatitis and cutaneous vasculitis have been associated with the use of flurbiprofen. We present the case of a 50-year-old man with flurbiprofen-induced generalized bullous FDE. To the best of our knowledge, the most serious form of FDE, the generalized bullous FDE, to be caused by flurbiprofen has not been reported previously.

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