Effect of Saline Cathartics on Gastrointestinal Transit Time of Activated Charcoal

1993 ◽  
Vol 12 (5) ◽  
pp. 403-405 ◽  
Author(s):  
O.E. Orisakwe ◽  
E. Ogbonna
Keyword(s):  
Sodium Chloride ◽  
Transit Time ◽  
Activated Charcoal ◽  
Gastrointestinal Transit ◽  
Sodium Sulphate ◽  
Abdominal Discomfort ◽  
Gastrointestinal Transit Time ◽  
Transit Times ◽  
The Mean ◽  
Salt Phase

The effects of saline cathartics on the gastrointestinal transit time of activated charcoal were investigated in six healthy volunteers. The study shows that the mean gastrointestinal transit times of charcoal alone were 29.3 h and 24.4, 15.4, 17.3 and 17.5 h with sodium chloride, sodium sulphate, magnesium sulphate alone and Andrew's Liver Salt respectively. Some volunteers complained of slight abdominal discomfort in all the phases except the Andrew's Liver Salt phase.

Effects of Magnesium Citrate and Clidinium Bromide on the Excretion of Activated Charcoal in Normal Subjects

DICP ◽  
1989 ◽  
Vol 23 (1) ◽  
pp. 26-29 ◽  
Author(s):  
Barbara Insley Vuignier ◽  
Gary M. Oderda ◽  
Richard L. Gorman ◽  
Wendy Klein-Schwartz ◽  
William A. Watson
Keyword(s):  
Transit Time ◽  
Activated Charcoal ◽  
Anticholinergic Drug ◽  
Gastrointestinal Transit ◽  
Anticholinergic Drugs ◽  
Magnesium Citrate ◽  
Concurrent Administration ◽  
Gastrointestinal Transit Time ◽  
Group I ◽  
Clidinium Bromide

The efficacy of cathartics in shortening the gastrointestinal transit time of activated charcoal (AC) in the presence of drugs that alter gastrointestinal motility has not been determined. We evaluated the effects of magnesium citrate (MC) on the excretion of activated charcoal in healthy volunteers alone and with concurrent administration of the anticholinergic drug clidinium bromide. Forty subjects were randomized to clidinium bromide 5 mg or placebo capsule (PC), followed by activated charcoal 15 g and magnesium citrate or a placebo liquid (PL). The onset and duration of excretion of activated charcoal were noted. Mean onset times for activated charcoal were: group I (CB, MC) 4.5 ± 2.1 h; group II (CB, PL) 17.0 ± 10.0 h; group III (PC, MC) 6.3 ± 5.8 h; and group IV (PC, PL) 20.6 ± 8.4 h. The onset of excretion of activated charcoal was statistically different in both magnesium citrate groups as compared with the placebo liquid groups. The duration of activated charcoal in the stool was similar among the groups. The addition of clidinium bromide did not appear to affect gastrointestinal transit time. These results support previous studies of the effects of cathartics on the excretion of activated charcoal, and suggest that cathartic efficacy is not inhibited by anticholinergic drugs when used in therapeutic doses.

scholarly journals Anatomic-radiographic aspects and gastrointestinal transit time in boa constrictor amarali stull, 1932 (Squamata, Boidae)

2020 ◽  
Vol 72 (6) ◽  
pp. 2201-2210
Author(s):  
V.M.F. Milken ◽  
M.L.C. Soares ◽  
N.B. Martins ◽  
A.L.Q. Santos
Keyword(s):  
Small Intestine ◽  
Contrast Medium ◽  
Transit Time ◽  
Barium Sulfate ◽  
Gastrointestinal Transit ◽  
Gastrointestinal Transit Time ◽  
Boa Constrictor ◽  
Filling Time ◽  
The Mean ◽  
Emptying Time

ABSTRACT The goal of this study was to describe the gastrointestinal transit technique in the Boa constrictor amarali. For that purpose, we obtained simple radiographic images of seven serpents, subsequently administering a 25mL/kg dose of barium sulfate and establishing a radiographic sequence at the following times: 5 minutes; 1, 2, 3, 6, 9, 24, 48, 72 and 96 hours, extending to 120 and 126 hours for one animal. The mean esophageal transit was 26.71±19.48 hours; the mean gastric filling time was 28.57±27.22 minutes and the emptying time was 60±12 hours; the mean filling time of the contrast medium in the small intestine was 3±2.16 hours and the emptying time was 97±15.65 hours. We also obtained the mean filling time of the large intestine, which was 40±11.31 hours. We found that the mean passage time of the contrast medium through the cranial gastrointestinal tract - until the complete elimination of barium sulfate from the small intestine -was 97±15.65 hours. In addition to determining the gastrointestinal transit time, the technique used allowed for the morphological identification of the alimentary canal.

scholarly journals Effects of Dietary Fiber on Gastrointestinal Transit Time, Fecal Properties and Fat Absorption in Rats.

1995 ◽  
Vol 176 (4) ◽  
pp. 227-238 ◽  
Author(s):  
AKIHIRO MUNAKATA ◽  
SATORU IWANE ◽  
MASAHIRO TODATE ◽  
SHIGEYUKI NAKAJI ◽  
KAZUO SUGAWARA
Keyword(s):  
Dietary Fiber ◽  
Transit Time ◽  
Gastrointestinal Transit ◽  
Fat Absorption ◽  
Gastrointestinal Transit Time

Lack of Improved Growth Outcome Related to Nonnutritive Sucking in Very Low Birth Weight Premature Infants Fed a Controlled Nutrient Intake: A Randomized Prospective Study

PEDIATRICS ◽  
1989 ◽  
Vol 83 (5) ◽  
pp. 706-716
Author(s):  
Judith A. Ernst ◽  
Karyl A. Rickard ◽  
Patricia R. Neal ◽  
Pao-Lo Yu ◽  
Tjien O. Oei ◽  
...  
Keyword(s):  
Birth Weight ◽  
Energy Expenditure ◽  
Low Birth Weight ◽  
Transit Time ◽  
Nutrient Intake ◽  
Very Low Birth Weight ◽  
Serum Proteins ◽  
Gastrointestinal Transit ◽  
Gastrointestinal Transit Time ◽  
Nonnutritive Sucking

The effect of nonnutritive sucking during gavage feeding on nutritional outcome and gastrointestinal transit time was evaluated in 18 premature appropriate for gestational age infants whose birth weights were \g=le\1,400 g and gestational ages were \g=le\30 weeks. Infants were randomized to a treatment (nonnutritive sucking infants received a pacifier for 30 minutes with each feeding, 12 times per day until they reached a weight of 1,500 g, eight times per day thereafter) or control (no pacifier) group. The nine nonnutritive sucking (five girls, four boys) and nine control (five girls, four boys) infants were treated for 14 days. Infants were without medical complications and were fed a single premature formula by intermittent gastric gavage at exactly 120 kcal/kg/d throughout the study period. Weight gain, linear growth, subscapular and triceps skinfold, and arm circumference accretions were assessed weekly. Serum proteins (albumin, prealbumin, retinol-binding protein, and transferrin) were measured weekly. Gastrointestinal transit times were measured weekly using carmine red markers. In contrast to previous studies, these data indicate no apparent effect of nonnutritive sucking on growth outcome, serum proteins, or gastrointestinal transit time in growing, very low birth weight infants when nutrient intake was controlled. In a subgroup of eight boys (four nonnutritive sucking, four control), energy and fat excretions were determined from 72-hour fecal collections and energy expenditure was estimated from six-hour cumulative heart rate measurements. Neither excretion of fat and calories nor estimated energy expenditure was affected significantly by nonnutritive sucking in this subgroup of baby boys. Fat excretion correlated well (r = .987) with energy excretion.

scholarly journals Establishment of a Protocol for Determining Gastrointestinal Transit Time in Mice Using Barium and Radiopaque Markers

2013 ◽  
Vol 14 (1) ◽  
pp. 45 ◽  
Author(s):  
Bolormaa Myagmarjalbuu ◽  
Myeong Ju Moon ◽  
Suk Hee Heo ◽  
Seo In Jeong ◽  
Jong-Seong Park ◽  
...  
Keyword(s):  
Transit Time ◽  
Gastrointestinal Transit ◽  
Gastrointestinal Transit Time ◽  
Radiopaque Markers
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