Influenza vaccination can induce new-onset anticardiolipins but not β2-glycoprotein-I antibodies among patients with systemic lupus erythematosus

Objectives IgA antiphospholipid antibodies (aPL) are prevalent in systemic lupus erythematosus (SLE) patients of African American, Afro-Caribbean and South African origin. Nevertheless, data from North Africa are lacking, and most studies use manufacturer-suggested cut-offs based on Caucasian controls. Therefore, we compared aPL isotypes in Sudanese and Swedish SLE patients using nation-based cut-offs. Methods Consecutive SLE patients and age- and sex-matched controls from Sudan ( N = 115/106) and Sweden ( N = 340/318) were included. All patients fulfilled the 1982 American College of Rheumatology SLE classification criteria. Antiphospholipid syndrome–related events were obtained from patients’ records. IgA/G/M anticardiolipin and anti-β2 glycoprotein I (β2GPI) were analysed with two independent assays. IgA anti-β2GPI domain 1 (D1) was also investigated. Manufacturers’ cut-offs and the 95th and 99th percentile cut-offs based on national controls were used. Results Sudanese patients and controls had higher levels and were more often positive for IgA aPL than Swedes when using manufacturers’ cut-offs. In contrast, using national cut-offs, the increase in IgA aPL among Sudanese patients was lost. Occurrence of IgA anti-D1 did not differ between the countries. Venous thromboses were less common among Sudanese patients and did not associate with aPL. No clinical associations were observed with IgA anti-β2GPI in Sudanese patients. Thromboses in Swedes were associated with IgG/M aPL. Fetal loss was associated with aPL in both cohorts. Conclusions IgA anti-β2GPI prevalence was higher among Sudanese compared to Swedish patients when manufacturers’ cut-offs were used. This situation was reversed when applying national cut-offs. Anti-D1 was not increased in Sudanese patients. Previous studies on populations of African origin, which demonstrate a high prevalence of IgA aPL positivity, should be re-evaluated using a similar cut-off approach.

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AB0531 OBESITY INCREASES THE INCIDENCE OF NEW-ONSET LUPUS NEPHRITIS AND ORGAN DAMAGE DURING FOLLOW-UP IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

10.1136/annrheumdis-2019-eular.3430 ◽

2019 ◽

Author(s):

Shin-Seok Lee ◽

Ji-Hyoun Kang ◽

Sung-Eun Choi ◽

Haimuzi Xu ◽

Dong-Jin Park

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Nephritis ◽

Lupus Erythematosus ◽

Organ Damage ◽

Systemic Lupus ◽

New Onset

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New-Onset Systemic Lupus Erythematosus During Chronic Dialysis and After Transplantation for Idiopathic Renal Failure

JCR Journal of Clinical Rheumatology ◽

10.1097/00124743-199710000-00008 ◽

1997 ◽

Vol 3 (5) ◽

pp. 282-285 ◽

Cited By ~ 3

Author(s):

David H. Lee ◽

William E. Davis ◽

Robert J. Quinet

Keyword(s):

Systemic Lupus Erythematosus ◽

Renal Failure ◽

Lupus Erythematosus ◽

Chronic Dialysis ◽

Systemic Lupus ◽

Onset Systemic Lupus Erythematosus ◽

New Onset

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Screening Tests of Reproductive Immunology in Systemic Lupus Erythematosus

Autoimmune Diseases ◽

10.1155/2012/812138 ◽

2012 ◽

Vol 2012 ◽

pp. 1-6 ◽

Cited By ~ 2

Author(s):

Zdenka Ulcova-Gallova ◽

Alice Mockova ◽

Miroslava Cedikova

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Phosphatidyl Ethanolamine ◽

Phosphatidyl Inositol ◽

Phosphatidyl Serine ◽

Sperm Cells ◽

Systemic Lupus ◽

Ethanolamine Phosphatidyl ◽

Glycoprotein I ◽

Beta 2

Female patients in reproductive age with systemic lupus erythematosus and fertility complications together are observed by rheumatologists, gynecologists, and reproductive immunologists. The paper notes the presence of autoantibodies to zona pellucida, to phospholipids (phosphatidyl serine, phosphatidyl ethanolamine, phosphatidyl inositol, phosphatidyl glycerol, phosphatidic acid, annexin V, beta-2 glycoprotein I, and cardiolipin) and of isoantibodies to sperm cells. Isoantibodies to sperm cells are not significantly predominant, but autoimmunity is well expressed in IgG positivity against phosphatidyl inositol, phosphatidyl ethanolamine, phosphatidyl serine, cardiolipin, and beta-2 glycoprotein I, as well as antizona pellucida antibodies in IgG isotype. According to the levels of autoantibodies we have to choose preventive treatment to protect mother and her foetus.

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