Protein S deficiency revealed by skin necrosis in a patient with lupus
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Protein S deficiency is rare in systemic lupus erythematosus (SLE) and is generally associated with the presence of antiphospholipid (APL) antibodies. Lack of protein S can cause skin necrosis, but when it does it is generally in response to warfarin exposure. In this article, we describe the case of a patient who had not received warfarin and without APL antibodies who developed extensive skin necrosis due to protein S deficiency. It is important to investigate protein S deficiency in patients with lupus and extensive skin ulcers as it is a sign of arterial thrombosis and venous thromboembolism.
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1995 ◽
Vol 48
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pp. 387-389
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1996 ◽
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pp. 689-691
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pp. 1416-1417
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1993 ◽
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pp. 853-857
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1989 ◽
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pp. 144-147
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1989 ◽
Vol 62
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pp. 1040-1040
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