Relationship between care model and disease activity states and health-related quality of life in systemic lupus erythematosus patients

Lupus ◽  
2021 ◽  
pp. 096120332110637
Author(s):  
Luciana Perea-Seoane ◽  
Estefania Agapito-Vera ◽  
Rocío V Gamboa-Cardenas ◽  
Geny Guzmán-Sánchez ◽  
Victor Román Pimentel-Quiroz ◽  
...  
Keyword(s):  
Disease Activity ◽  
Lupus Erythematosus ◽  
Health Related Quality ◽  
Care Model ◽  
Regular Care ◽  
Related Quality ◽  
Health Related ◽  
Activity State ◽  
Comprehensive Care Model

Objective To assess whether the care model (comprehensive vs regular) has any impact on the clinical outcomes of systemic lupus erythematosus patients. Methods Between August 2019 and January 2020, we evaluated SLE patients being cared for at two Peruvian hospitals to define the impact of care model on disease activity state and health-related quality of life (HRQoL). Disease activity was ascertained with the SLEDAI-2K and the Physician Global Assessment (PGA) which allows to define Lupus Low Disease Activity State (LLDAS) and Remission. HRQoL was measured with the LupusQoL. The association between care model and disease activity (Remission and LLDAS) state was examined using a binary logistic regression model. The association with HRQoL was examined with a linear regression model. All multivariable analyses were adjusted for possible confounders. Results 266 SLE patients were included, 227 from the comprehensive care model and 39 from the regular care model. The regular care model was associated with a lower probability of achieving remission (OR 0.381; CI: 95% 0.163–0.887) and LLDAS (OR 0.363; CI: 95% 0.157–0.835). Regular care was associated with a better HRQoL in two domains (pain and emotional health). We found no association between the care model and the other HRQoL domains. Conclusion A comprehensive care model was associated with the probability of achieving remission and LLDAS but had no apparent impact on the patients’ HRQoL.

BMI, disease activity, and health-related quality-of-life in systemic lupus erythematosus

2010 ◽  
Vol 29 (12) ◽  
pp. 1413-1417 ◽  
Author(s):  
Li-Wei Zhu ◽  
Tao Zhang ◽  
Hai-Feng Pan ◽  
Xiang-Pei Li ◽  
Dong-Qing Ye
Keyword(s):  
Quality Of Life ◽  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Health Related Quality ◽  
Systemic Lupus ◽  
Related Quality ◽  
Health Related

scholarly journals The Impact of Cytokines on the Health-Related Quality of Life in Patients with Systemic Lupus Erythematosus

2019 ◽  
Vol 8 (6) ◽  
pp. 857 ◽  
Author(s):  
Warren David Raymond ◽  
Gro Østli Eilertsen ◽  
Sharanyaa Shanmugakumar ◽  
Johannes Cornelis Nossent
Keyword(s):  
Disease Activity ◽  
Lupus Erythematosus ◽  
Health Related Quality ◽  
Sf 36 ◽  
Cytokine Levels ◽  
Related Quality ◽  
Health Related ◽  
Ifn Γ ◽  
Tgf Β1

Introduction: Systemic lupus erythematosus (SLE) reduces the health-related quality of life (HRQoL), even during periods of disease quiescence. We investigated whether subclinical inflammation as reflected by cytokine levels is linked with reduced HRQoL. Methods: A cross-sectional study of SLE patients (n = 52, mean age 47.3, 86.5% female) who completed a Short Form Health Survey-36 (SF-36) questionnaire. The clinical and demographic data, scores for the disease activity (SLEDAI-2K), organ damage (SDI), and laboratory data were collected simultaneously. The autoantibody and cytokine levels (IFN-γ, IL-1β, IL-4, IL-6, IL-10, IL-12, IL-17, BAFF, TNF-α, TGF-β1, MIP-1α, MIP-1β and MCP-1 (levels in pg/mL) were quantified by sandwich ELISA. The comparisons and associations were assessed non-parametrically, and a multiple regression determined the effect sizes (ES) of the variables on the SF-36 domain and summary scores. Results: The SF-36 summary and domain scores for SLE patients were significantly (20–40%) lower than in a comparable control group, with the exception of the Mental Health scores (p = 0.06). SLE patients had a normal body mass index (BMI) (median, 24.2 kg/m2), a high rate of smoking (69.2%), and usage of social security benefits (90.4%). TGF-β1 (ES 0.06), IL-12 (ES −0.11), IFN-γ (ES 0.07) and MCP-1 (ES 0.06) influenced the SF-36 domain scores; and MCP-1 (ES 0.04) influenced the Mental Health Summary Score (MCS). Obvious manifestations, including patient visual analogue scale (VAS) (ES −2.84 to −6.29), alopecia (ES −14.89), malar rash (ES −14.26), and analgesic requirement (ES −19.38), independently influenced the SF-36 items; however, the SF-36 scores were not reflected by the physician VAS or disease activity (SLEDAI-2K). Conclusions: Cytokines had a minimal impact on HRQoL in SLE patients, especially compared to visible skin manifestations, central nervous system (CNS) damage, and pain. Better tools are needed to capture HRQoL in measures of disease activity.

Effects of a Continuous Care Model on Patients’ Knowledge and Health-Related Quality of Life in Systemic Lupus Erythematosus

2017 ◽  
Vol 42 (6) ◽  
pp. E9-E18 ◽  
Author(s):  
Mohammad Sahebalzamani ◽  
Hojjatollah Farahani ◽  
Mojgan Tabatabaee Jamarani ◽  
Seyedeh Tahereh Faezi ◽  
Kamran Moradi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Health Related Quality ◽  
Care Model ◽  
Systemic Lupus ◽  
Continuous Care ◽  
Related Quality ◽  
Health Related

Better Health‐Related Quality of Life in Systemic Lupus Erythematosus Predicted by Low Disease Activity State/Remission: Data From the Peruvian Almenara Lupus Cohort

2020 ◽  
Vol 72 (8) ◽  
pp. 1159-1162 ◽  
Author(s):  
Manuel F. Ugarte‐Gil ◽  
Rocío V. Gamboa‐Cárdenas ◽  
Cristina Reátegui‐Sokolova ◽  
Mariela Medina‐Chinchón ◽  
Francisco Zevallos ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Health Related Quality ◽  
Systemic Lupus ◽  
Low Disease Activity ◽  
Related Quality ◽  
Health Related ◽  
Activity State

scholarly journals 175 Low disease activity state (LDAS) predicts a better health-related quality of life (HRQoL) in systemic lupus erythematosus (SLE) patients

2019 ◽  
Author(s):  
Manuel F Ugarte-Gil ◽  
Rocío Gamboa-Cárdenas ◽  
Cristina Reátegui-Sokolova ◽  
Mariela Medina-Chinchón ◽  
Francisco Zevallos ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Health Related Quality ◽  
Systemic Lupus ◽  
Low Disease Activity ◽  
Related Quality ◽  
Health Related ◽  
Activity State

IMPACT OF THERAPY ON HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS (ACCORDING TO THE RENAISSANCE REGISTER)

2019 ◽  
Vol 57 (4) ◽  
pp. 421-425
Author(s):  
L. D. Vorobyeva ◽  
E. A. Aseeva ◽  
S. K. Solovyev ◽  
G. M. Koilubaeva ◽  
S. I. Glukhova
Keyword(s):  
Disease Activity ◽  
Lupus Erythematosus ◽  
Standard Therapy ◽  
Emotional Health ◽  
Therapy Group ◽  
Health Related Quality ◽  
Standard Therapy Group ◽  
Related Quality ◽  
Health Related

Objective: to assess changes in health-related quality of life (HRQoL) in patients with systemic lupus erythematosus (SLE) during performed therapy.Subjects and methods. The investigation included 128 patients with reliable SLE who fulfilled the 2012 SLICC criteria. Sixty-eight patients received standard therapy; 60 used biological agents (BA). During the first visit and at 12 months, all the patients were assessed for disease activity using by SLEDAI-2K and for organ damage employing the SLICC damage index (DI). HRQoL was assessed by the LupusQoL questionnaire that was filled out by the patients independently.Results and discussion. At Visit 1, the disease activity index averaged 8.0±7.3 in the standard therapy group and 15.4±7.6 in the BA group (p≤0.001); DI was 1.2±0.9 and 1.8±1.8, respectively (p=0.008). BA-treated patients had significantly lower HRQoL scores on all questionnaire scales, except «dependence on others» and «emotional health» ones Both the standard therapy and BA groups showed significantly lower disease activity during Visit 2 at 12 months. HRQoL assessment revealed significant improvements in the scales «pain», «planning», «intimate relationships», «emotional health», «body image», and «fatigue» in the BA group. The standard therapy group had a statistically significant improvement in the scale «dependence on others». All the other scales of the questionnaire displayed a positive change in HRQoL; however, it did not reach statistical significance.

Factors detrimental to work productivity and daily activities in systemic lupus erythematosus patients – Analysis of the German LuLa study

Lupus ◽  
2021 ◽  
pp. 096120332110450
Author(s):  
Anna Kernder ◽  
Christina Düsing ◽  
Jutta Richter ◽  
Ralph Brinks ◽  
Rebecca Fischer-Betz ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Work Productivity ◽  
Multivariate Regression Analysis ◽  
Daily Activities ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

Objective The aim of this study was to identify factors associated with impaired work productivity and impaired daily activities in patients with systemic lupus erythematosus (SLE). Methods The LuLa study is a longitudinal patient-reported study. Beyond sociodemographic data, work productivity, daily activities and fatigue, several other clinical outcome parameters (e.g. mental health–related quality of life and physical functioning, disease activity, damage and pain) were surveyed with validated questionnaires. The effects of confounders on work productivity (WPAI 2) and daily activity domains (WPAI 4) were studied by multivariate regression analysis. Results A total of 585 patients completed the questionnaire of whom 259 were employed and analysed. The median impairment in work productivity (WPAI 2) was 20% (Q1–3 0–40), and the median impairment in daily activities (WPAI 4) was 30% (Q1–3 10–50%). Multivariate regression analysis revealed that fatigue, pain, disease activity and health-related quality of life affected WPAI 2 and 4. Furthermore, we observed distinct synergistic effects of fatigue, disease activity and pain on both work productivity and daily activities: a higher impact of fatigue was associated with the reported extent of pain or disease activity. Conclusion In employed patients with SLE, impaired work productivity and impaired daily activities were frequently reported. Fatigue, pain, disease activity and health-related quality of life demonstrated a detrimental impact, with a synergistic effect of fatigue, disease activity and pain. Hence, both optimized pain management and targeted immunomodulatory therapy are important for preserving active participation in life among patients with fatigue.

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