Roles of Pericytes in Stroke Pathogenesis
2018 ◽
Vol 27
(12)
◽
pp. 1798-1808
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Keyword(s):
Stroke is a cerebrovascular disorder that affects many people worldwide. In addition to the well-established functions of astrocytes and microglia in stroke pathogenesis, pericytes also play an important role in stroke progression and recovery. As perivascular multi-potent cells and an important component of the blood–brain barrier (BBB), pericytes have been shown to exert a large variety of functions, including serving as stem/progenitor cells and maintaining BBB integrity. Here in this review, we summarize the roles of pericytes in stroke pathogenesis, with a focus on their effects in cerebral blood flow, BBB integrity, angiogenesis, immune responses, scar formation and fibrosis.
Keyword(s):
1996 ◽
Vol 18
(1)
◽
pp. 83-86
◽
1981 ◽
Vol 1
(3)
◽
pp. 349-356
◽
1979 ◽
Vol 237
(2)
◽
pp. H178-H184
◽
1985 ◽
Vol 5
(2)
◽
pp. 275-281
◽
Keyword(s):
1981 ◽
Vol 36
(5)
◽
pp. 1731-1738
◽
Keyword(s):
1979 ◽
Vol 107
(3)
◽
pp. 227-232
◽
Keyword(s):