Population dynamics of inducible nitric oxide synthase production by LPSand LPS/IFNγ-stimulated mouse macrophages

1994 ◽  
Vol 1 (4) ◽  
pp. 227-233 ◽  
Author(s):  
J.L. Pace ◽  
C.J. Lowenstein ◽  
T.A. Phillips ◽  
L.C. Chen ◽  
D.C. Morrison ◽  
...  
Science ◽  
1992 ◽  
Vol 256 (5054) ◽  
pp. 225-228 ◽  
Author(s):  
Q. Xie ◽  
H. Cho ◽  
J Calaycay ◽  
R. Mumford ◽  
K. Swiderek ◽  
...  

1999 ◽  
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pp. 1945-1952 ◽  
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Yu-Chih Liang ◽  
Ying-Tang Huang ◽  
Shu-Huei Tsai ◽  
Shoei-Yn Lin-Shiau ◽  
Chieh-Fu Chen ◽  
...  

2000 ◽  
Vol 78 (11) ◽  
pp. 861-866 ◽  
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Thomas Moeslinger ◽  
Roswitha Friedl ◽  
Ivo Volf ◽  
Monika Brunner ◽  
Elisabeth Koller ◽  
...  

Padma 28 is a mixture of herbs used in traditional Tibetan medicine with anti-inflammatory activities. We investigated the effects of Padma 28 on nitric oxide (NO) production by the inducible nitric oxide synthase (iNOS) in lipopolysaccharide stimulated mouse macrophages (RAW 264.7). Padma 28 (0-900 µg/mL) induced a concentration dependent inhibition of inducible nitric oxide synthesis. iNOS protein expression showed a concentration dependent reduction as revealed by immunoblotting when cells were incubated with increasing amounts of Padma 28. Padma 28 decreased iNOS mRNA levels as shown by RT-PCR. Aqueous extracts from costi amari radix (costus root, the dried root of Saussurea lappa) and the outer cover of myrobalani fructus (the dried fruit of Terminalia chebula), constituents of the complex herb preparation Padma 28, were found to inhibit inducible nitric oxide synthesis by decreasing iNOS protein and iNOS mRNA levels. The inhibition of inducible nitric oxide synthesis might contribute to the anti-inflammatory activities of Padma 28.Key words: inducible nitric oxide synthase, mouse macrophages, myrobalans, radix costae.


2003 ◽  
Vol 171 (10) ◽  
pp. 5631.3-5631
Author(s):  
Sharon Daniliuc ◽  
Haim Bitterman ◽  
Michal A. Rahat ◽  
Amalia Kinarty ◽  
Doron Rosenzweig ◽  
...  

2003 ◽  
Vol 171 (6) ◽  
pp. 3225-3232 ◽  
Author(s):  
Sharon Daniliuc ◽  
Haim Bitterman ◽  
Michal A. Rahat ◽  
Amalia Kinarty ◽  
Doron Rosenzweig ◽  
...  

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