scholarly journals Association of plasma haptoglobin concentration and other biomarkers with bovine respiratory disease status in pre-weaned dairy calves

2018 ◽  
Vol 31 (1) ◽  
pp. 40-46 ◽  
Author(s):  
Sonia J. Moisá ◽  
Sharif S. Aly ◽  
Terry W. Lehenbauer ◽  
William J. Love ◽  
Paul V. Rossitto ◽  
...  
Keyword(s):  
Respiratory Disease ◽  
Bovine Respiratory Disease ◽  
Area Under The Curve ◽  
Disease Status ◽  
Dairy Calves ◽  
Receiver Operating Characteristic Curves ◽  
Haptoglobin Concentration ◽  
Complete Blood Counts ◽  
Nested Case Control ◽  
Plasma Haptoglobin

We conducted a nested, case-control study of pre-weaned dairy calves ( n = 477; 4 California dairy farms) to assess the association between bovine respiratory disease (BRD) and hematologic biomarkers, including plasma haptoglobin (Hp) and plasma bactericide (PB). At each location, heifer or bull dairy calves were observed 2–4 times per week until confirmed as BRD-positive using parallel interpretation of thoracic ultrasound examination and auscultation. In addition, control calves were enrolled after being confirmed as BRD-negative using ultrasound and auscultation. Complete blood counts (CBC), PB, and Hp concentrations were measured. Hp values were higher in calves with confirmed BRD than in controls ( p < 0.01). The area under the curve (AUC) for the various biomarkers was obtained from the corresponding receiver operating characteristic curves. The AUC for Hp was 0.68, a value greater than those for PB or the remaining CBC parameters, indicating that Hp may be the most useful biomarker of BRD in pre-weaned dairy calves. The cutoff value for Hp was 0.195 g/L.

scholarly journals Regional management practices and prevalence of bovine respiratory disease in California's preweaned dairy calves

2019 ◽  
Vol 102 (8) ◽  
pp. 7583-7596 ◽  
Author(s):  
B.M. Karle ◽  
G.U. Maier ◽  
W.J. Love ◽  
S.A. Dubrovsky ◽  
D.R. Williams ◽  
...  
Keyword(s):  
Respiratory Disease ◽  
Management Practices ◽  
Bovine Respiratory Disease ◽  
Dairy Calves ◽  
Regional Management

scholarly journals Development of a novel clinical scoring system for on-farm diagnosis of bovine respiratory disease in pre-weaned dairy calves

PeerJ ◽  
2014 ◽  
Vol 2 ◽  
pp. e238 ◽  
Author(s):  
William J. Love ◽  
Terry W. Lehenbauer ◽  
Philip H. Kass ◽  
Alison L. Van Eenennaam ◽  
Sharif S. Aly
Keyword(s):  
Respiratory Disease ◽  
Scoring System ◽  
Bovine Respiratory Disease ◽  
Dairy Calves ◽  
Clinical Scoring ◽  
On Farm

scholarly journals A novel risk assessment tool for bovine respiratory disease in preweaned dairy calves

2020 ◽  
Vol 103 (10) ◽  
pp. 9301-9317 ◽  
Author(s):  
G.U. Maier ◽  
W.J. Love ◽  
B.M. Karle ◽  
S.A. Dubrovsky ◽  
D.R. Williams ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Respiratory Disease ◽  
Assessment Tool ◽  
Bovine Respiratory Disease ◽  
Dairy Calves ◽  
Risk Assessment Tool

scholarly journals Nuclear Magnetic Resonance-based Metabolomics of Blood Plasma from Dairy Calves Infected with the Main Causal Agents of Bovine Respiratory Disease (BRD)

2021 ◽  
Author(s):  
Mariana Santos-Rivera ◽  
Nicholas C. Fitzkee ◽  
Rebecca A. Hill ◽  
Richard E. Baird ◽  
Ellianna Blair ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Blood Plasma ◽  
Respiratory Disease ◽  
Nmr Spectra ◽  
Bovine Respiratory Disease ◽  
Dairy Calves ◽  
Proton Nuclear Magnetic Resonance ◽  
H Nmr ◽  
Nuclear Magnetic

Abstract Each year, Bovine Respiratory Disease (BRD) results in significant economic loss in the cattle sector, and novel metabolic profiling and early diagnosis techniques represent a promising tool for developing effective measures for disease management. Here, proton - Nuclear Magnetic Resonance (1H - NMR) spectra were used to characterize metabolites from blood plasma collected from dairy calves intentionally infected with the main BRD causal agents, bovine respiratory syncytial virus (BRSV) and Mannheimia haemolytica (MH), to generate a well-defined metabolomic profile under controlled conditions. In response to infection, 42 metabolites (BRSV = 27, MH = 24) changed in concentration compared to the Baseline (non-infected) state. Fuel substrates and products exhibited a particularly strong effect, reflecting imbalances that occur during the immune response. Glucose levels decreased only during bacterial infection, suggesting that the clinical signs of bacterial BRD are more energetically taxing than those of viral BRD. Furthermore, 1H - NMR spectra from Baseline and Infected samples were discriminated with an accuracy, sensitivity, and specificity ≥ 95% using chemometrics to model the changes associated with disease, suggesting that metabolic profiles can be used for further development and validation of diagnostic tools.

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