scholarly journals Clinical, histopathologic, and immunohistochemical features of 13 cases of canine gallbladder neuroendocrine carcinoma

2020 ◽  
pp. 104063872097817
Author(s):  
Kevin M. O’Brien ◽  
Braelyn J. Bankoff ◽  
Peri K. Rosenstein ◽  
Daphne C. Clendaniel ◽  
Melissa D. Sánchez ◽  
...  
Keyword(s):  
Neuroendocrine Carcinoma ◽  
Chromogranin A ◽  
Neuron Specific Enolase ◽  
Surgical Excision ◽  
Abdominal Ultrasound ◽  
Transferase Activity ◽  
Gamma Glutamyl Transferase ◽  
Mixed Breed ◽  
Positive Immunoreactivity ◽  
Glutamyl Transferase

In this retrospective descriptive study, we characterized the clinical, histologic, and immunohistochemical features of 13 cases of canine gallbladder neuroendocrine carcinoma (GB-NEC). Immunohistochemical stains for neuroendocrine (neuron-specific enolase [NSE], chromogranin A, synaptophysin) and gastrin markers were evaluated, and clinicopathologic and follow-up data were obtained for all cases. The average age at diagnosis was 8.9 y, and breeds included 6 Boston Terriers, 2 Bichon Frise, 1 Poodle, 1 English Bulldog, 1 French Bulldog, and 2 mixed-breed dogs. Boston Terriers were overrepresented in this cohort, and therefore a breed predilection is possible. Most dogs were presented with emesis and elevated liver enzyme activities: 13 of 13 had elevated alanine aminotransferase and alkaline phosphatase activities; 8 of 13 had elevated aspartate aminotransferase activity; 7 of 13 had elevated gamma-glutamyl transferase activity. Abdominal ultrasound and/or exploratory surgery revealed a gallbladder mass. All neoplasms had similar histologic features and positive immunoreactivity for NSE, chromogranin A, synaptophysin, and gastrin. Vascular invasion was noted in 8 of 13 neoplasms, and metastasis was present in 6 of 13 cases (4 hepatic and 2 pulmonary metastases). The median survival time was 3.7 y in patients who died; 5 of 8 deaths were directly attributed to the GB-NEC, 3 of which had metastatic spread. GB-NECs have the potential to metastasize; however, surgical excision may be curative in a subset of dogs.

scholarly journals Serum gamma-glutamyl transferase activity is an independent predictor for cardiovascular disease in Obstructive Sleep Apnea Syndrome

2011 ◽  
Vol 105 (4) ◽  
pp. 637-642 ◽  
Author(s):  
Asiye Kanbay ◽  
Elif Kaya ◽  
Hakan Buyukoglan ◽  
Nezihe Ozdogan ◽  
Mehmet Gungor Kaya ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Independent Predictor ◽  
Sleep Apnea Syndrome ◽  
Transferase Activity ◽  
Gamma Glutamyl Transferase ◽  
Obstructive Sleep ◽  
Apnea Syndrome ◽  
Glutamyl Transferase

Acute Acetaminophen Nephrotoxicity and Urinary Gamma- Glutamyl Transferase Activity in Rats

1997 ◽  
Vol 14 (1) ◽  
Author(s):  
Şukran Kocaoğlu ◽  
Aysen Karan ◽  
Tayfun Berkan ◽  
Gülçin Başdemir
Keyword(s):  
Transferase Activity ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase

Gamma glutamyl transferase activity in rat colon during experimental colonic carcinogenesis

1988 ◽  
Vol 37 (1) ◽  
pp. 52-55 ◽  
Author(s):  
O. J. Traynor ◽  
Y. C. Lee ◽  
K. B. Whittaker ◽  
A. R. Zinsmeister ◽  
D. W. Moss ◽  
...  
Keyword(s):  
Rat Colon ◽  
Transferase Activity ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Colonic Carcinogenesis ◽  
Glutamyl Transferase

Serum gamma-glutamyl transferase activity in thyrotoxicosis

1985 ◽  
Vol 145 (1) ◽  
pp. 179c-179
Author(s):  
A. Konrady
Keyword(s):  
Transferase Activity ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase

Salivary gamma-glutamyl transferase activity in internal diseases

1984 ◽  
Vol 144 (9) ◽  
pp. 1804-1806 ◽  
Author(s):  
J. Jimenez-Alonso
Keyword(s):  
Transferase Activity ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase

Quantitative fractionation of alkaline phosphatase isoenzymes according to their thermostability.

1976 ◽  
Vol 22 (1) ◽  
pp. 42-48 ◽  
Author(s):  
C PetitClerc
Keyword(s):  
Alkaline Phosphatase ◽  
Liver Disease ◽  
Phosphatase Activity ◽  
Alkaline Phosphatase Activity ◽  
Normal Serum ◽  
Transferase Activity ◽  
Gamma Glutamyl Transferase ◽  
Heat Labile ◽  
Alkaline Phosphatase Isoenzymes ◽  
Glutamyl Transferase

Abstract Continuous monitoring of heat denaturation of a mixture of alkaline phosphatase isoenzymes at 60 degrees C and pH 7.5 permits the simultaneous direct identification and quantitation of three isoenzymes: the placental isoenzyme, the L-phenylalanine-sensitive intestinal isoenzyme, and the liver isoenzyme (hepatocytic). The isoenzyme that is principally of bone origin cannot be identified as such without the help of other diagnostic aids and the patient's medical history. All human tissues contain alkaline phosphatase, many organs more than one of the isoenzymes. Liver alkaline phosphatase, which constitutes 40-50% of normal serum alkaline phosphatase activity, was measured in the serum of persons with various liver diseases. Its activity exceeded normal in all types of liver disease; in 80% of cases this increase was accompanied by increased gamma-glutamyl-transferase activity, but the quantitative correlationship (r = 0.54) was not as good as expected if both enzymes come from the same source and are indices of liver dieases. Liver alkaline phosphatase activity increases in the blood early in liver disease, before most liver tests show abnormalities. The other major isoenzyme of normal serum probably represents a mixture of isoenzymes from bone and reticulo-endothelial and vascular tissues, which all contain the same "very heat-labile" alkaline phosphatase. Cord blood and children's sera contain mostly this very heat-labile isoenzyme.

Electrical properties of rabbit early distal convoluted tubule in primary culture

1989 ◽  
Vol 257 (2) ◽  
pp. F288-F299 ◽  
Author(s):  
J. Merot ◽  
M. Bidet ◽  
B. Gachot ◽  
S. Le Maout ◽  
N. Koechlin ◽  
...  
Keyword(s):  
Primary Culture ◽  
Rabbit Kidney ◽  
Kidney Cortex ◽  
Transferase Activity ◽  
Gamma Glutamyl Transferase ◽  
Transport Pathway ◽  
Apical Side ◽  
Transepithelial Voltage ◽  
Glutamyl Transferase ◽  
Convoluted Tubules

Distal bright convoluted tubules (DCTb) were microdissected from rabbit kidney cortex and cultured in a hormonally defined medium. The quality and the degree of polarization of the growing epithelia were assessed by indirect immunofluorescence studies using a monoclonal antibody raised against the apical membrane of the DCTb in situ. The cultured monolayers had a high hexokinase activity and a low gamma-glutamyl transferase activity compared with cultured proximal convoluted tubules. Adenosine 3',5'-cyclic monophosphate production was stimulated by calcitonin and insensitive to parathyroid hormone, vasopressin, and isoproterenol. Both 20- and 30-day-old cultures developed an apical-negative transepithelial potential of -3.1 and -22.3 mV, respectively. Amiloride reversibly reduced the voltage by 90% only when applied on the apical side of the monolayers. Phenamil (10(-8), 10(-6) M) had the same effect as amiloride. Calcitonin reversibly decreased the transepithelial voltage. These data support the hypothesis that, in the DCTb in primary culture, the transepithelial voltage is due to the presence of Na channels and that calcitonin modulates this transport pathway.

PLATELET MEMBRANE SPECIFIC GAMMA GLUTAMYL TRANSFERASE ACTIVITY IS A MARKER OF STENT RESTENOSIS

2008 ◽  
Vol 9 (1) ◽  
pp. 144
Author(s):  
K. Demirtas ◽  
L.E. Sade ◽  
U. Bal ◽  
A. Aydinalp ◽  
A. Yildirir ◽  
...  
Keyword(s):  
Platelet Membrane ◽  
Transferase Activity ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Stent Restenosis ◽  
Glutamyl Transferase
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