Dedifferentiated Liposarcoma With Rhabdomyosarcomatous Differentiation Producing HCG: A Case Report of a Diagnostic Pitfall

2018 ◽  
Vol 26 (5) ◽  
pp. 448-452 ◽  
Author(s):  
Elena Maryamchik ◽  
Kirill A. Lyapichev ◽  
Bradford Halliday ◽  
Andrew E. Rosenberg
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Retroperitoneal Tumor ◽  
Dedifferentiated Liposarcoma ◽  
Testicular Germ Cell Tumors ◽  
Retroperitoneal Mass ◽  
Testicular Germ Cell ◽  
Diagnostic Pitfall ◽  
First Case

We report a first case of paraneoplastic human chorionic gonadotropin (HCG) production in a dedifferentiated liposarcoma with rhabdosarcomatous differentiation in an 83-year-old man with a retroperitoneal mass, unilateral scrotal enlargement, and a serum HCG level of 843 IU/L. Core biopsy of the retroperitoneal mass revealed rhabdomyosarcoma. Orchiectomy revealed a paratesticular dedifferentiated liposarcoma with rhabdosarcomatous differentiation. Fluorescence in situ hybridization analysis performed on both the retroperitoneal and paratesticular masses revealed amplification of MDM2. The retroperitoneal tumor was interpreted as metastatic dedifferentiated liposarcoma with the dedifferentiated component represented by rhabdomyosarcoma. HCG production is a common feature of testicular germ cell tumors, less common in carcinomas, and extremely rare in sarcomas. Accordingly, sarcomas secreting HCG are a potential diagnostic pitfall, and raise the differential diagnosis of germ cell tumors and a variety of carcinomas. HCG production by carcinomas is a known poor prognostic finding, however the significance of its production in sarcomas is unknown.

Cytogenetic evidence that carcinoma in situ is the precursor lesion for invasive testicular germ cell tumors

1994 ◽  
Vol 77 (2) ◽  
pp. 194 ◽  
Author(s):  
Jannie van Echten ◽  
Marian Stoepker ◽  
Beike Leegte ◽  
Leendert Looijenga ◽  
Bauke de Jong ◽  
...  
Keyword(s):  
Germ Cell ◽  
Carcinoma In Situ ◽  
Germ Cell Tumors ◽  
Testicular Germ Cell Tumors ◽  
Precursor Lesion ◽  
Testicular Germ Cell ◽  
Cytogenetic Evidence

scholarly journals Simultaneous intracranial and testicular germ cell tumors: illustrative case

2021 ◽  
Vol 1 (3) ◽  
Author(s):  
Lei Han ◽  
Jie Lu ◽  
Luxiong Fang ◽  
Songtao Qi ◽  
Ye Song
Keyword(s):  
Germ Cell ◽  
Mature Teratoma ◽  
Germ Cell Tumors ◽  
Testicular Tumor ◽  
Cystic Teratoma ◽  
Pineal Region ◽  
Illustrative Case ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell ◽  
First Case

BACKGROUNDSimultaneous intracranial and testicular germ cell tumors (GCTs) are extremely rare, leading to a lack of adequate experience in their treatment. Therefore, the authors report a case of this kind of GCT.OBSERVATIONSA 5-year-old boy was admitted to the hospital with headache and vomiting. Computed tomography and magnetic resonance imaging suggested the possibility of a GCT in the pineal region. The value of the serum tumor marker alpha-fetoprotein (AFP) was 5,396.1 μg/L, and β-human chorionic gonadotropin levels were within the normal range. Subsequently, the tumor was removed, and the final pathological result was a mixed GCT. Therefore, chemotherapy and radiation were added. However, the authors found a testicular tumor on ultrasound at the same time, and pathology after surgery suggested a mature cystic teratoma. Following treatment, the patient recovered well, and AFP levels dropped to normal values.LESSONSTo the authors’ knowledge, this report is the fourth case of simultaneous intracranial and testicular GCTs and the first case of a simultaneous mixed GCT in the pineal region and mature teratoma of the testis. A combination of surgery, chemotherapy, and radiation therapy for mixed GCTs in the pineal region and surgical excision for testicular reproductive cell tumors are effective in these patients, but long-term monitoring is required.

scholarly journals Assessment of piRNA biogenesis and function in testicular germ cell tumors and their precursor germ cell neoplasia in situ

BMC Cancer ◽  
2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Ildar V. Gainetdinov ◽  
Yulia V. Skvortsova ◽  
Sofia A. Kondratieva ◽  
Alexey Klimov ◽  
Alexey A. Tryakin ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell ◽  
And Function

scholarly journals Cytogenetic evidence that carcinoma in situ is the precursor lesion for invasive testicular germ cell tumors

1995 ◽  
Vol 85 (2) ◽  
pp. 133-137 ◽  
Author(s):  
Jannie van Echten ◽  
Ruud J.H.L.M. van Gurp ◽  
Marian Stoepker ◽  
Leendert H.J. Looijenga ◽  
Bauke de Jong ◽  
...  
Keyword(s):  
Germ Cell ◽  
Carcinoma In Situ ◽  
Germ Cell Tumors ◽  
Testicular Germ Cell Tumors ◽  
Precursor Lesion ◽  
Testicular Germ Cell ◽  
Cytogenetic Evidence

scholarly journals Laparoscopic resection of a residual retroperitoneal tumor mass of nonseminomatous testicular germ cell tumors

2011 ◽  
Vol 26 (2) ◽  
pp. 458-467 ◽  
Author(s):  
Çiğdem Öztürk ◽  
Robert J. van Ginkel ◽  
Ruby M. Krol ◽  
Jourik A. Gietema ◽  
Hendrik S. Hofker ◽  
...  
Keyword(s):  
Germ Cell ◽  
Laparoscopic Resection ◽  
Germ Cell Tumors ◽  
Retroperitoneal Tumor ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell ◽  
Tumor Mass
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