Intratubular Malignant Germ Cells (Carcinoma in SITU) Accompanying Invasive Testicular Germ Cell Tumors

1985 ◽  
Vol 133 (3) ◽  
pp. 413-415 ◽  
Author(s):  
Frederick A. Klein ◽  
Myron R. Melamed ◽  
Willet F. Whitmore
Keyword(s):  
Germ Cell ◽  
Germ Cells ◽  
Carcinoma In Situ ◽  
Germ Cell Tumors ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell

Cytogenetic evidence that carcinoma in situ is the precursor lesion for invasive testicular germ cell tumors

1994 ◽  
Vol 77 (2) ◽  
pp. 194 ◽  
Author(s):  
Jannie van Echten ◽  
Marian Stoepker ◽  
Beike Leegte ◽  
Leendert Looijenga ◽  
Bauke de Jong ◽  
...  
Keyword(s):  
Germ Cell ◽  
Carcinoma In Situ ◽  
Germ Cell Tumors ◽  
Testicular Germ Cell Tumors ◽  
Precursor Lesion ◽  
Testicular Germ Cell ◽  
Cytogenetic Evidence

scholarly journals Cytogenetic evidence that carcinoma in situ is the precursor lesion for invasive testicular germ cell tumors

1995 ◽  
Vol 85 (2) ◽  
pp. 133-137 ◽  
Author(s):  
Jannie van Echten ◽  
Ruud J.H.L.M. van Gurp ◽  
Marian Stoepker ◽  
Leendert H.J. Looijenga ◽  
Bauke de Jong ◽  
...  
Keyword(s):  
Germ Cell ◽  
Carcinoma In Situ ◽  
Germ Cell Tumors ◽  
Testicular Germ Cell Tumors ◽  
Precursor Lesion ◽  
Testicular Germ Cell ◽  
Cytogenetic Evidence

scholarly journals hH-Rev107, a class II tumor suppressor gene, is expressed by post-meiotic testicular germ cells and CIS cells but not by human testicular germ cell tumors

Oncogene ◽  
2001 ◽  
Vol 20 (37) ◽  
pp. 5155-5163 ◽  
Author(s):  
Sylvie Siegrist ◽  
Chloé Féral ◽  
Mounia Chami ◽  
Brigitte Solhonne ◽  
Marie-Geneviève Mattéi ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Germ Cell ◽  
Tumor Suppressor Gene ◽  
Germ Cells ◽  
Germ Cell Tumors ◽  
Class Ii ◽  
Suppressor Gene ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell

scholarly journals Assessment of piRNA biogenesis and function in testicular germ cell tumors and their precursor germ cell neoplasia in situ

BMC Cancer ◽  
2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Ildar V. Gainetdinov ◽  
Yulia V. Skvortsova ◽  
Sofia A. Kondratieva ◽  
Alexey Klimov ◽  
Alexey A. Tryakin ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell ◽  
And Function

Dedifferentiated Liposarcoma With Rhabdomyosarcomatous Differentiation Producing HCG: A Case Report of a Diagnostic Pitfall

2018 ◽  
Vol 26 (5) ◽  
pp. 448-452 ◽  
Author(s):  
Elena Maryamchik ◽  
Kirill A. Lyapichev ◽  
Bradford Halliday ◽  
Andrew E. Rosenberg
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Retroperitoneal Tumor ◽  
Dedifferentiated Liposarcoma ◽  
Testicular Germ Cell Tumors ◽  
Retroperitoneal Mass ◽  
Testicular Germ Cell ◽  
Diagnostic Pitfall ◽  
First Case

We report a first case of paraneoplastic human chorionic gonadotropin (HCG) production in a dedifferentiated liposarcoma with rhabdosarcomatous differentiation in an 83-year-old man with a retroperitoneal mass, unilateral scrotal enlargement, and a serum HCG level of 843 IU/L. Core biopsy of the retroperitoneal mass revealed rhabdomyosarcoma. Orchiectomy revealed a paratesticular dedifferentiated liposarcoma with rhabdosarcomatous differentiation. Fluorescence in situ hybridization analysis performed on both the retroperitoneal and paratesticular masses revealed amplification of MDM2. The retroperitoneal tumor was interpreted as metastatic dedifferentiated liposarcoma with the dedifferentiated component represented by rhabdomyosarcoma. HCG production is a common feature of testicular germ cell tumors, less common in carcinomas, and extremely rare in sarcomas. Accordingly, sarcomas secreting HCG are a potential diagnostic pitfall, and raise the differential diagnosis of germ cell tumors and a variety of carcinomas. HCG production by carcinomas is a known poor prognostic finding, however the significance of its production in sarcomas is unknown.

Sign in / Sign up

Export Citation Format

Share Document