Diagnostic Challenge of Sarcomatoid Variant of ALK-Positive Anaplastic Large Cell Lymphoma: Case Report and Updated Systematic Literature Review

2021 ◽  
pp. 106689692098696
Author(s):  
Fuqin Song ◽  
Shili Yu ◽  
Meng Jia ◽  
Hongwen Gao ◽  
Ping-Li Sun
Keyword(s):  
Anaplastic Large Cell Lymphoma ◽  
Inflammatory Myofibroblastic Tumor ◽  
Cell Lymphoma ◽  
Sarcomatoid Carcinoma ◽  
Inflammatory Cells ◽  
Large Cell ◽  
Good Prognosis ◽  
Variable Number ◽  
Diagnostic Challenge ◽  
Large Cell Lymphoma

The sarcomatoid variant of anaplastic large cell lymphoma is an extremely rare histologic pattern of anaplastic large cell lymphoma that consists of spindle-shaped neoplastic cells and is easily misdiagnosed as a soft tissue sarcoma. We report a case of the sarcomatoid variant of anaplastic large cell lymphoma that was initially diagnosed as an inflammatory myofibroblastic tumor in our hospital and as liposarcoma after consultation. This article analyzed the features of this entity by reviewing the literature. Only 15 cases have been reported, most of which were misdiagnosed as sarcoma, sarcomatoid carcinoma, or inflammatory myofibroblastic tumor. Most of the reported cases showed a myxoid stroma, with a variable number of inflammatory cells. The hallmark cells usually can be found by careful evaluation of the slides. Immunohistochemistry including CD30, EMA, and ALK are the most useful for diagnosis. Most are III or IV stage, and have a good prognosis after chemotherapy.

Lymphohistiocytic anaplastic large cell lymphoma involving skin: A diagnostic challenge

2009 ◽  
Vol 205 (4) ◽  
pp. 283-287 ◽  
Author(s):  
Shih-Sung Chuang ◽  
Yen-Chuan Hsieh ◽  
Hongtao Ye ◽  
Wei-Shou Hwang
Keyword(s):  
Anaplastic Large Cell Lymphoma ◽  
Cell Lymphoma ◽  
Large Cell ◽  
Diagnostic Challenge ◽  
Large Cell Lymphoma

scholarly journals Perils and Pitfalls Regarding Differential Diagnosis and Treatment of Primary Cutaneous Anaplastic Large-Cell Lymphoma

2011 ◽  
Vol 11 ◽  
pp. 1048-1055 ◽  
Author(s):  
Michael D. Diamantidis ◽  
Athena D. Myrou
Keyword(s):  
Differential Diagnosis ◽  
T Cell ◽  
Anaplastic Large Cell Lymphoma ◽  
Cell Lymphoma ◽  
Correct Diagnosis ◽  
Large Cell ◽  
Skin Lesions ◽  
Good Prognosis ◽  
Response To Treatment ◽  
Large Cell Lymphoma

Primary cutaneous anaplastic large-cell lymphoma (PC-ALCL), belonging to the CD30+ T-cell lymphoproliferative disorders (PCLPDs), is a rare T-cell lymphoma, presenting on the skin and characterized by very good prognosis and response to treatment in the majority of cases. Nevertheless, PC-ALCL must be distinguished from secondary skin lesions in systemic ALCL, which confer a poor prognosis, and other CD30+ PCLPDs, reactive conditions, or borderline cases. Given their rarity and heterogeneity, these entities represent diagnostic and therapeutic challenges, thus requiring a multidisciplinary approach and expertise to ensure appropriate diagnosis and management. There are several perils and pitfalls that exist regarding the differential diagnosis, the possible progression, and the treatment of PC-ALCL. Careful staging, correlation of clinical findings with histopathology and immunopathology, and thorough follow-up are essential in order to achieve a correct diagnosis and proper treatment of the disease.

Breast Implant-Associated Anaplastic Large-Cell Lymphoma Can Be a Diagnostic Challenge for Pathologists

2014 ◽  
Vol 58 (1) ◽  
pp. 103-107 ◽  
Author(s):  
Matthieu Talagas ◽  
Arnaud Uguen ◽  
Françoise Charles-Petillon ◽  
Virginie Conan-Charlet ◽  
Véronique Marion ◽  
...  
Keyword(s):  
Anaplastic Large Cell Lymphoma ◽  
Cell Lymphoma ◽  
Breast Implant ◽  
Large Cell ◽  
Diagnostic Challenge ◽  
Large Cell Lymphoma

scholarly journals Primary Cutaneous Anaplastic Large Cell Lymphoma of the Oral Cavity Successfully Treated with Brentuximab Vedotin

2019 ◽  
Vol 2019 ◽  
pp. 1-3 ◽  
Author(s):  
Federico Meconi ◽  
Roberto Secchi ◽  
Raffaele Palmieri ◽  
Sara Vaccarini ◽  
Vito Mario Rapisarda ◽  
...  
Keyword(s):  
Anaplastic Large Cell Lymphoma ◽  
Lymphoproliferative Disorder ◽  
Unusual Case ◽  
Cell Lymphoma ◽  
Large Cell ◽  
Good Prognosis ◽  
Brentuximab Vedotin ◽  
Rare Disorders ◽  
Large Cell Lymphoma ◽  
Head Neck

Primary cutaneous anaplastic large cell lymphoma is a CD-30 positive lymphoproliferative disorder with good prognosis, usually treated with radiation therapy and surgery. Head, neck, and extremities are the most frequently involved sites. In this paper, we describe an unusual case of oral localization, recurring after skin-involving radiotherapy, successfully treated with sixteen cycles of brentuximab vedotin. This could be a more effective approach with a less detrimental toll for treating these rare disorders.

scholarly journals The management of breast implant-associated anaplastic large cell lymphoma in the setting of pregnancy: seeking for clinical practice guidelines

2021 ◽  
Vol 48 (4) ◽  
pp. 373-377
Author(s):  
Rossella Elia ◽  
Michele Maruccia ◽  
Aurelia De Pascale ◽  
Arianna Di Napoli ◽  
Giuseppe Ingravallo ◽  
...  
Keyword(s):  
Anaplastic Large Cell Lymphoma ◽  
Cell Lymphoma ◽  
Early Stage ◽  
Breast Implant ◽  
Pregnant Patient ◽  
Large Cell ◽  
Good Prognosis ◽  
World Health ◽  
First Case ◽  
Large Cell Lymphoma

Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a recently described form of T-cell non-Hodgkin lymphoma now formally recognized by the World Health Organization classification of lymphoid neoplasms. The aim of this paper is to report the first case of BIA-ALCL diagnosed in a pregnant patient. It is well known that BIA-ALCL appears as an indolent lymphoma with a good prognosis when diag-nosed at early stages and clinical guidelines for its management have been clearly published. Nevertheless, they lack a standardized approach for BIA-ALCL during pregnancy. With limited experience in our case, treatment has been safely postponed after term without affecting patient’s overall prognosis and without fetal complication. The fact that the disease was diagnosed at an early stage (stage I) undoubtedly influenced the course of treatment. A multidisciplinary approach weighing the risks and benefits of treatment is of paramount importance in order to ensure the best possible outcome for both the mother and her child and clinical update guidelines should be issued.

scholarly journals Breast implant-associated anaplastic large cell lymphoma: a diagnostic challenge

2020 ◽  
Vol 35 (1) ◽  
pp. 118-120
Author(s):  
Ana Paula De-Azambuja ◽  
Anne Karoline Groth ◽  
Juliana Jung ◽  
Fabiola Gevert ◽  
Samir Kanaan Nabhan
Keyword(s):  
Anaplastic Large Cell Lymphoma ◽  
Cell Lymphoma ◽  
Breast Implant ◽  
Large Cell ◽  
Diagnostic Challenge ◽  
Large Cell Lymphoma
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