scholarly journals Benign Metastasizing Leiomyoma in the Lung Presenting in a Phyllodes-Like Pattern Mimicking a Biphasic Tumor: A Case Report

2021 ◽  
pp. 106689692110350
Author(s):  
Saleh Fadel ◽  
Patrick J. Villeneuve ◽  
Ashish Gupta ◽  
Sarah Strickland ◽  
Marcio Gomes
Keyword(s):  
Final Diagnosis ◽  
Soft Tissue Tumors ◽  
Lung Epithelium ◽  
Benign Metastasizing Leiomyoma ◽  
Radiographic Findings ◽  
Native Lung ◽  
Metastasizing Leiomyoma ◽  
Immunohistochemical Studies ◽  
Patient’S History ◽  
Biphasic Tumor

Primary biphasic tumors of the lung are rare. Lung lesions with a biphasic pattern are far more commonly primary or metastatic soft tissue tumors with entrapped native respiratory epithelium, giving the false impression of a biphasic tumor. We report a case of bilateral benign metastasizing leiomyomas in a 69-year-old female where the tumor cells diffusely entrapped native respiratory glands in a phyllodes-like pattern. The radiographic characteristics and histologic appearance were not immediately diagnostic and covered a wide differential. Reaching the final diagnosis required the use of immunohistochemical studies as well as correlation with the patient's history and radiographic findings. To the best of our knowledge, this is the first report of pulmonary benign metastasizing leiomyoma presenting in a phyllodes-like pattern. This case illustrates the importance of considering entrapment of native lung epithelium in the differential diagnosis of biphasic-appearing lung tumors.

Benign Metastasizing Leiomyoma of the Uterus

1999 ◽  
Vol 123 (10) ◽  
pp. 960-962 ◽  
Author(s):  
Jose M. Esteban ◽  
Warren M. Allen ◽  
Raymond H. Schaerf
Keyword(s):  
Low Grade ◽  
Benign Metastasizing Leiomyoma ◽  
Nuclear Pleomorphism ◽  
Benign Leiomyoma ◽  
Histopathologic Evaluation ◽  
Primary Neoplasm ◽  
Metastasizing Leiomyoma ◽  
Immunohistochemical Studies ◽  
Leiomyoma Of The Uterus ◽  
Rule Out

Abstract Benign uterine leiomyoma metastasizing to the lung is a recognized entity that has been reported infrequently in the medical literature. There is persisting controversy regarding the pathogenesis and biology of these lesions. We report a well-studied and well-characterized case of benign leiomyoma metastasizing to the lung. The patient was a 72-year-old woman with an enlarged uterus that contained several leiomyomas with usual histology. Areas of fibrosis, hyalinization, edema, and focal infarction together with small foci with mildly increased cellularity and minimal nuclear pleomorphism were seen. Careful and repeated mitotic counts ranged from 0 to 2 mitoses per 10 high-power fields. In summary, based on histopathologic criteria, the neoplasm was determined to be a focally cellular benign leiomyoma. Four years later, the patient underwent surgical resection of a single nodule in the lung, which had been detected on routine radiographs. Histopathologic evaluation showed a low-grade leiomyosarcoma with moderate nuclear pleomorphism, necrosis, and brisk mitotic activity. Immunohistochemical studies performed on both neoplasms showed them to be of mesenchymal derivation with smooth muscle differentiation. Both neoplasms expressed estrogen receptors with moderate to strong intensity. The patient received no further treatment and, to date, shows no evidence of recurrent disease. The diagnosis of benign metastasizing leiomyoma can only be made with certainty after careful and extensive sampling of the primary tumor to exclude small foci of sarcoma and of the pulmonary tumor to rule out a primary neoplasm. Although it is biologically peculiar, benign metastasizing leiomyoma should continue to be recognized as a distinct entity because current morphologic criteria do not allow primary myometrial tumors to be reclassified as leiomyomas of uncertain malignant potential even if they have metastasized to the lung.

Unusual CT Findings of a Benign Metastasizing Leiomyoma Presenting with Multiple Cavitary Nodules: A Case Report

2007 ◽  
Vol 57 (3) ◽  
pp. 239
Author(s):  
Ji Eun Ahn ◽  
Kyung-Hyun Do ◽  
Eun Jin Chae ◽  
Joon Beom Seo ◽  
Jin Seong Lee ◽  
...  
Keyword(s):  
Case Report ◽  
Benign Metastasizing Leiomyoma ◽  
Ct Findings ◽  
Metastasizing Leiomyoma

scholarly journals 364 Management of benign metastasizing leiomyoma: a report of three cases

2020 ◽  
Author(s):  
K Inoue ◽  
M Yamaguchi ◽  
T Ueda ◽  
R Isono ◽  
Y Takimoto ◽  
...  
Keyword(s):  
Benign Metastasizing Leiomyoma ◽  
Metastasizing Leiomyoma

Benign metastasizing leiomyoma

Herz ◽  
2013 ◽  
Vol 39 (7) ◽  
pp. 867-870 ◽  
Author(s):  
A. Cai ◽  
L. Li ◽  
H. Tan ◽  
Y. Mo ◽  
Y. Zhou
Keyword(s):  
Benign Metastasizing Leiomyoma ◽  
Metastasizing Leiomyoma

scholarly journals An Unusual Cause of Pulmonary Nodules in the Emergency Department

2015 ◽  
Vol 2015 ◽  
pp. 1-5
Author(s):  
Ryan Yu ◽  
Melanie Ferri
Keyword(s):  
Emergency Department ◽  
Smooth Muscle ◽  
Clinical Presentation ◽  
Pulmonary Nodules ◽  
Pleuritic Chest Pain ◽  
Benign Metastasizing Leiomyoma ◽  
Spindle Cells ◽  
Smooth Muscle Tumors ◽  
Metastasizing Leiomyoma ◽  
Tomography Scan

We report a 51-year-old woman who presented to the emergency department with left-sided pleuritic chest pain 2 weeks after subtotal hysterectomy and bilateral salpingo-oophorectomy for a leiomyomatous uterus. Computed tomography scan of the chest revealed bilateral pulmonary nodules. Biopsy showed cytologically bland spindle cells without overt malignant features. Immunohistochemistry confirmed smooth muscle phenotype, in keeping with a clinicopathologic diagnosis of benign metastasizing leiomyoma (BML). BML does not frequently come to the attention of the emergency physician because it is rare and usually asymptomatic. When symptomatic, its clinical presentation depends on the site(s) of metastasis, number, and size of the smooth muscle tumors. Emergent presentations of BML are reviewed.

Natural Decrease of Benign Metastasizing Leiomyoma

CHEST Journal ◽  
2000 ◽  
Vol 117 (3) ◽  
pp. 921 ◽  
Author(s):  
Tadashi Arai ◽  
Yo Yasuda ◽  
Tadatake Takaya ◽  
Maroki Shibayama
Keyword(s):  
Benign Metastasizing Leiomyoma ◽  
Natural Decrease ◽  
Metastasizing Leiomyoma
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