Investigation of Muscle Imbalance in the Leg in Symptomatic Forefoot Pes Cavus: A Multidisciplinary Study

Foot & Ankle ◽  
1992 ◽  
Vol 13 (9) ◽  
pp. 489-501 ◽  
Author(s):  
Martin C. Tynan ◽  
Leslie Klenerman ◽  
T.R. Helliwell ◽  
R.H.T. Edwards ◽  
Michael Hayward

The cross-sectional areas of the peroneal and anterior muscle compartments at the same level in the upper leg were measured using magnetic resonance imaging in 41 cases of forefoot pes cavus. The pes cavus group included idiopathic cases and pes cavus associated with Charcot-Marie-Tooth disease, Friedreich's ataxia, cerebral palsy, status postpoliomyelitis, nerve trauma, and spinal cord tethering. Thirty-nine of these cases were symptomatic. The results were compared with studies of 11 normal controls. It was found that in the majority of cases of forefoot cavus, the peroneal compartment was enlarged relative to the anterior compartment when compared with the normal controls. Biopsies of the tibialis anterior and peroneus longus muscles in 18 patients with forefoot pes cavus showed that any relative expansion of the peroneus longus was not due to pseudohypertrophy. Overaction of the peroneus longus in comparison to its antagonist the tibialis anterior is proposed as an important factor in the pathogenesis of the majority of symptomatic cases of forefoot pes cavus.

2010 ◽  
Vol 42 (2) ◽  
pp. 262-267 ◽  
Author(s):  
Joshua Burns ◽  
Adam Scheinberg ◽  
Monique M. Ryan ◽  
Kristy J. Rose ◽  
Robert A. Ouvrier

2018 ◽  
Vol 59 (1) ◽  
pp. 122-125
Author(s):  
Amro M. Stino ◽  
Said Atway ◽  
Michael Anthony ◽  
David Kline ◽  
John T. Kissel

2009 ◽  
Vol 44 (6) ◽  
pp. 479-486
Author(s):  
Daniel Augusto Maranho ◽  
José Batista Volpon

2011 ◽  
Vol 258 (9) ◽  
pp. 1594-1602 ◽  
Author(s):  
José Berciano ◽  
Elena Gallardo ◽  
Antonio García ◽  
Ana L. Pelayo-Negro ◽  
Jon Infante ◽  
...  

Neurology ◽  
2012 ◽  
Vol 78 (Meeting Abstracts 1) ◽  
pp. P05.147-P05.147
Author(s):  
I. Karakis ◽  
P. Kang ◽  
B. Darras ◽  
H. Jones

Neurology ◽  
2017 ◽  
Vol 89 (9) ◽  
pp. 927-935 ◽  
Author(s):  
Francis B. Panosyan ◽  
Matilde Laura ◽  
Alexander M. Rossor ◽  
Chiara Pisciotta ◽  
Giuseppe Piscosquito ◽  
...  

Objective:To extend the phenotypic description of Charcot-Marie-Tooth disease (CMTX1) and to draw new genotype-phenotype relationships.Methods:Mutations in GJB1 cause the main X-linked form of CMTX (CMTX1). We report cross-sectional data from 160 patients (from 120 different families, with 89 different mutations) seen at the Inherited Neuropathies Consortium centers.Results:We evaluated 87 males who had a mean age of 41 years (range 10–78 years) and 73 females who had a mean age of 46 years (range 15–84 years). Sensory-motor polyneuropathy affects both sexes, more severely in males than in females, and there was a strong correlation between age and disease burden in males but not in females. Compared with females, males had more severe reduction in motor and sensory neurophysiology parameters. In contrast to females, the radial nerve sensory response in older males tended to be more severely affected compared with younger males. Median and ulnar nerve motor amplitudes were also more severely affected in older males, whereas ulnar nerve motor potentials tended to be more affected in older females. Conversely, there were no statistical differences between the sexes in other features of the disease, such as problems with balance and hand dexterity.Conclusions:In the absence of a phenotypic correlation with specific GJB1 mutations, sex-specific distinctions and clinically relevant attributes need to be incorporated into the measurements for clinical trials in people with CMTX1.ClinicalTrials.gov identifier:NCT01193075.


2017 ◽  
Vol 23 (2) ◽  
pp. e1702 ◽  
Author(s):  
Gita M. Ramdharry ◽  
Louise Reilly-O'Donnell ◽  
Robert Grant ◽  
Mary M. Reilly

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