Increased Incidence of Villitis in Placentas Exposed to Chemotherapy During Pregnancy: Is There a Correlation?

2019 ◽  
Vol 22 (6) ◽  
pp. 540-545 ◽  
Author(s):  
Diana Kantarovich ◽  
Sydney Archer ◽  
Nasim Khoshnam ◽  
Eman Al-Haddad ◽  
Daniela Moncaleano ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cervical Cancer ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Inflammatory Process ◽  
Toxic Effects ◽  
Unknown Etiology ◽  
Second Trimester ◽  
Pathologic Examination ◽  
Inflammatory Changes

We have identified 9 pregnant patients who were diagnosed with malignancy and initiated chemotherapy during their second trimester (cervical cancer [n = 3], leukemia [n = 3], breast cancer [n = 2], and Hodgkin’s lymphoma [n = 1]). Five of the patients’ placentas were small for gestational age (SGA). Pathologic examination revealed inflammatory changes in 4 of the placentas: 2 from the SGA placentas and 2 from non-SGA placentas. Examination revealed 3 placentas with villitis of unknown etiology (VUE) and 1 with intervillositis; all were negative for bacterial and viral cultures and by immunohistochemical (IHC) stains. In the VUE cases, IHC stains showed positivity of CD25+/FOXP3+ with focal positivity and CD3 and CD4 IHC were focally to strongly positive. Literature suggests that the use of chemotherapy during pregnancy can be detrimental to both the mother and the fetus; however, there has been limited focus on the effects of chemotherapy on the placenta. We suggest that the inflammatory process noted in the placentas is due to chemotherapy-induced toxic effects.

Second trimester contingent screening for small for gestational age neonates

2021 ◽  
Author(s):  
U. Nowacka ◽  
I. Papastefanou ◽  
A. Bouariu ◽  
A. Syngelaki ◽  
R. Akolekar ◽  
...  
Keyword(s):  
Gestational Age ◽  
Small For Gestational Age ◽  
Second Trimester

Early second-trimester low umbilical coiling index predicts small-for-gestational-age fetuses.

2001 ◽  
Vol 20 (11) ◽  
pp. 1183-1188 ◽  
Author(s):  
S Degani ◽  
Z Leibovich ◽  
I Shapiro ◽  
R Gonen ◽  
G Ohel
Keyword(s):  
Gestational Age ◽  
Small For Gestational Age ◽  
Second Trimester ◽  
Umbilical Coiling Index

Birthweight and Chemotherapy Exposure in Women Diagnosed with Breast Cancer during Pregnancy

2020 ◽  
Author(s):  
Taylor S. Freret ◽  
Pedro Exman ◽  
Erica L. Mayer ◽  
Sarah E. Little ◽  
Katherine E. Economy
Keyword(s):  
Breast Cancer ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Chemotherapy Regimen ◽  
Small Sample ◽  
Maternal Outcomes ◽  
Z Score ◽  
Cancer In Pregnancy ◽  
Lower Birthweight ◽  
In Pregnancy

Objective Breast cancer is one of the most frequently diagnosed cancers in pregnancy and is commonly treated with chemotherapy. To date, studies examining effects of chemotherapy during pregnancy on fetal growth have yielded conflicting results, and most are limited by small sample sizes or are nonspecific with respect to cytotoxic regimen or type of cancer treated. We sought to evaluate the effect of chemotherapy for breast cancer in pregnancy on birthweight and small for gestational age infants. Study Design This is a retrospective cohort study of 74 women diagnosed with pathologically confirmed breast cancer during pregnancy between 1997 and 2018 at one of three academic medical centers, who had a singleton birth with known birthweight. Forty-nine received chemotherapy and 25 did not receive chemotherapy. Linear regression modeling was used to compare birthweight (by gestational age and sex-specific z-score) by chemotherapy exposure. Subanalyses of specific chemotherapy regimen and duration of chemotherapy exposure were also performed. Placental, neonatal, and maternal outcomes were also analyzed by chemotherapy exposure. Results In the adjusted model, chemotherapy exposure was associated with lower birthweight (∆ z-score =  − 0.49, p = 0.03), but similar rates of small for gestational age (defined as birthweight <10th percentile for gestational age) infants (8.2 vs. 8.0%, p = 1.0; Fisher’s exact test). Each additional week of chemotherapy (∆ z-score =  − 0.05, p = 0.03) was associated with decreased birthweight, although no association was found with specific chemotherapy regimen. Chemotherapy exposure was associated with lower median placental weight percentile by gestational age (9th vs. 75th, p < 0.05). Secondary maternal outcomes were similar between the group that did and did not receive chemotherapy. Conclusion Chemotherapy for breast cancer in pregnancy in this cohort is associated with lower birthweight but no difference in the rate of small for gestational age infants. Key Points

Second-Trimester 3-Dimensional Placental Sonography as a Predictor of Small-for-Gestational-Age Birth Weight

2016 ◽  
Vol 35 (8) ◽  
pp. 1693-1702 ◽  
Author(s):  
Hayley S. Quant ◽  
Mary D. Sammel ◽  
Samuel Parry ◽  
Nadav Schwartz
Keyword(s):  
Birth Weight ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Second Trimester ◽  
3 Dimensional

Second-trimester prediction of delivery of a small-for-gestational-age neonate: integrating sequential Doppler information, fetal biometry, and maternal characteristics

2014 ◽  
Vol 34 (11) ◽  
pp. 1037-1043 ◽  
Author(s):  
Viola Seravalli ◽  
Dana M. Block-Abraham ◽  
Ozhan M. Turan ◽  
Lauren E. Doyle ◽  
Miriam G. Blitzer ◽  
...  
Keyword(s):  
Gestational Age ◽  
Small For Gestational Age ◽  
Second Trimester ◽  
Maternal Characteristics ◽  
Fetal Biometry

Short Femur in the Second Trimester Scan Is Related to Maternal Preeclampsia and Small for Gestational Age Newborns

2020 ◽  
Vol 47 (8) ◽  
pp. 615-623
Author(s):  
Walter Ventura ◽  
Maria Teresa Prieto-Sánchez ◽  
Juan L. Delgado ◽  
Miriam Pertegal ◽  
Antonia López ◽  
...  
Keyword(s):  
Gestational Age ◽  
Small For Gestational Age ◽  
Second Trimester
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