Potential Diagnostic Value of Fluorescein Angiography and Color Doppler Imaging in Primary Open-Angle Glaucoma

Purpose To evaluate with color Doppler imaging (CDI), in patients with primary open-angle glaucoma (PDAG), the possible influence on ocular hemodynamics of a beta-blocking agent with intrinsic sympathomimetic acitivity (carteolol 2%) compared to a beta-blocker agent without this activity. Methods A study was carried out on 20 patients, with bilateral POaG, intraocular pressure (IOP) ≤ 20 mmHg, all treated twice a day with timolol maleate 0.5% ophthalmic solution. The visual field was evaluated (Octopus 2000 perimeter, G1 program) examining the mean sensitivity (MS) and the mean defect (MD). CDI was carried out to evaluate the resistance index of the internal carotid artery (ICA), the ophthalmic artery (OA), the central retinal artery (CRA), and the short posterior ciliary arteries (SPCA). After these examinations, the therapy was changed to carteolol 2% twice a day. After six months of treatment the examinations were repeated. The data were analysed statistically using Student's t test. Results The mean intraocular pressure during treatment with timolol 0.5% was 16.7 ± 1.67 mmHg and 16.33 ± 1.72 mmHg after treatment with carteolol 2%, the difference not being significant (p=0.494). After six months of treatment with carteolol 2% the MS increased significantly from 22.4 ± 2.5 dB to 24.1 ± 1.8 dB (p=0.018), and the mean defect (MD) fell from 5.3 ± 0.8 dB to 4.7 ± 0.6 dB (p=0.011). There was no significant difference in the resistance index of the CA, the OA and the CRA with the two treatments, whereas the resistance index of the SPCA dropped significantly, from 0.80 ± 0.05 to 0.77 ± 0.02 (p = 0.017). Conclusions CDI did not show significant differences in the resistance indexes of the internal CA, the OA, and the CRA after treatment with carteolol 2% but the resistance index of the SPCA was significantly reduced. Carteolol 2% induced significant changes in the perimetric indexes examined, with an increase in MS and a decrease in MD. These findings suggest that the intrinsic sympathomimetic activity of carteolol may reduce peripheral vascular resistance of the SCA, thus improving perfusion of the optic nerve head, with a protective effect on visual function.

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Short-Term Effects of Acupuncture on Open-Angle Glaucoma in Retrobulbar Circulation: Additional Therapy to Standard Medication

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2011/157090 ◽

2011 ◽

Vol 2011 ◽

pp. 1-6 ◽

Cited By ~ 9

Author(s):

Shin Takayama ◽

Takashi Seki ◽

Toru Nakazawa ◽

Naoko Aizawa ◽

Seri Takahashi ◽

...

Keyword(s):

Open Angle Glaucoma ◽

Color Doppler ◽

Resistive Index ◽

Color Doppler Imaging ◽

Doppler Imaging ◽

Open Angle ◽

Before And After ◽

Standard Medication ◽

Ciliary Artery ◽

Additional Therapy

Background. The relation between glaucoma and retrobulbar circulation in the prognosis has been indicated.Purpose. To investigate the effects of acupuncture on retrobulbar circulation in open-angle glaucoma (OAG) patients.Methods. Eleven OAG patients (20 eyes with OAG) who were treated by topical antiglaucoma medications for at least 3 months were enrolled. Acupuncture was performed once at acupoints BL2, M-HN9, ST2, ST36, SP6, KI3, LR3, GB20, BL18, and BL23 bilaterally. Retrobulbar circulation was measured with color Doppler imaging, and intraocular pressure (IOP) was also measured at rest and one hour after rest or before and after acupuncture.Results. TheΔvalue of the resistive index in the short posterior ciliary artery (P<.01) and theΔvalue of IOP (P<.01) were decreased significantly by acupuncture compared with no acupuncture treatment.Conclusions. Acupuncture can improve the retrobulbar circulation and IOP, which may indicate the efficacy of acupuncture for OAG.

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Color Doppler imaging in ocular hypertension and open-angle glaucoma

Graefe s Archive for Clinical and Experimental Ophthalmology ◽

10.1007/s00417-003-0809-3 ◽

2003 ◽

Vol 242 (2) ◽

pp. 125-129 ◽

Cited By ~ 29

Author(s):

Cengiz Akarsu ◽

M. Yasemin Karadeniz Bilgili

Keyword(s):

Ocular Hypertension ◽

Open Angle Glaucoma ◽

Color Doppler ◽

Color Doppler Imaging ◽

Doppler Imaging ◽

Open Angle

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Color Doppler Imaging Analysis of Ocular Blood Flow Velocities in Normal Tension Glaucoma Patients: A Meta-Analysis

Journal of Ophthalmology ◽

10.1155/2015/919610 ◽

2015 ◽

Vol 2015 ◽

pp. 1-24 ◽

Cited By ~ 1

Author(s):

Shuo Xu ◽

Shouyue Huang ◽

Zhongjing Lin ◽

Wangmin Liu ◽

Yisheng Zhong

Keyword(s):

Color Doppler ◽

Meta Analysis ◽

Color Doppler Imaging ◽

Normal Tension Glaucoma ◽

Diagnostic Value ◽

Doppler Imaging ◽

Diagnostic Tools ◽

Significant Heterogeneity ◽

Cochrane Central Register ◽

Ischemic Change

Background. To evaluate the potential diagnostic value of CDI of retrobulbar hemodynamic changes in NTG patients.Methods. Relevant publications which included PSV, EDV, and RI of OA, CRA, NPCA, and TPCA in NTG patients and normal controls measured by CDI were retrieved from the Cochrane Central Register of Controlled Trials, PubMed, the ISI Web of Knowledge, and EMBASE from 1990 to 2014. Subgroup analyses were made based on IOP-lowering medications uses.Result. In OA, there was significant decrease of PSV with moderate heterogeneity (P<0.00001,I2=49%) and significant decrease of EDV with significant heterogeneity (P=0.0005,I2=87%) in NTG patients. In CRA, similar results of PSV (P<0.00001,I2=42%) and EDV (P<0.00001,I2=80%) were detected. Significant decrease of PSV and EDV with significant heterogeneity was also found in both NPCA (P<0.0001,I2=70%;P<0.0001,I2=76%; resp.) and TPCA (P<0.00001,I2=54%;P<0.00001,I2=65%; resp.). Statistically significant increases of RI were found in CRA (P=0.0002,I2=89%) and TPCA (P=0.02,I2=81%) with significant heterogeneities, though RI in OA (P=0.25,I2=94%) and in NPCA (P=0.15,I2=86%) showed no statistical changes with significant heterogeneities.Conclusions. Ischemic change of retrobulbar hemodynamics is one of the important manifestations of NTG. Hemodynamic parameters measured by CDI might be potential diagnostic tools for NTG.

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