Episodic hyperlibidinism in multiple sclerosis

2001 ◽  
Vol 7 (1) ◽  
pp. 67-70 ◽  
Author(s):  
Francisco de Assis Aquino Gondim ◽  
Florian P Thomas
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Case Report ◽  
Sexual Function ◽  
Frontal Lobe ◽  
Frontal Lobe Dysfunction ◽  
Psychiatric Conditions

Background: Changes in sexual function are commonly associated with MS and occur in many forms. Hypersexual thought or behavior are rare, but can present on the background of persistent cognitive impairment or psychiatric conditions such as mania, whereas isolated hypersexuality is still rarer. Case Report: We describe the clinical neuropsychological electrodiagnostic neuroimaging and endocrine findings in a MS patient with episodes of greatly increased libido. Imaging and neuropsychological studies indicated frontal lobe dysfunction; hormone studies showed no significant changes. Conclusion: Episodic hypersexuality can be a recurrent transient manifestation of MS.

scholarly journals Cognitive Function in Multiple Sclerosis: A Subcortical Pattern of Neuropsychological Impairment?

1991 ◽  
Vol 4 (3) ◽  
pp. 129-141 ◽  
Author(s):  
Carlo Caltagirone ◽  
Giovanni Augusto Carlesimo ◽  
Lucia Fadda ◽  
Sabina Roncacci
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Frontal Lobe ◽  
Neuropsychological Tests ◽  
Neuropsychological Impairment ◽  
Frontal Lobe Damage

In order to evaluate cognitive impairment in multiple sclerosis (MS) neuropsychological tests were administered to 25 patients with clinically definite disease. Four (16%) showed diffuse cognitive impairment, whereas the others, compared with controls showed a specific deficit on tests known to be sensitive to frontal lobe damage. These results are interpreted in the light of current hypotheses relating to subcortical contributions in cognition.

Dementia in multiple sclerosis: report of a case with cortical grey matter involvement and frontal-type-like clinical features

2011 ◽  
Vol 26 (S2) ◽  
pp. 485-485
Author(s):  
R. Correia ◽  
D. Dias ◽  
A.J. Bastos-Leite ◽  
E. Rio ◽  
R. Curral
Keyword(s):  
Multiple Sclerosis ◽  
Case Report ◽  
White Matter ◽  
Frontal Lobe ◽  
Cognitive Dysfunction ◽  
Clinical Features ◽  
Grey Matter ◽  
Psychiatric Symptoms ◽  
Eating Behaviour ◽  
Cortical Grey Matter

Background/introductionAlthough multiple sclerosis (MS), a demyelinating disease of unknown aetiology, is primarily a white matter disease, it may also involve the grey matter, a feature not often demonstrated in vivo by means of magnetic resonance imaging (MRI). The involvement of cortical grey matter in MS may account for cognitive dysfunction and behavioural abnormalities.ObjectiveThe purpose of this report is to present the case of a patient with MS and clinical features mimicking dementia of the frontal type due to clear-cut cortical grey matter involvement in the left frontal lobe.Case reportA 55-year-old woman with relapsing remitting MS developed a clinical picture characterized by frontal deficits (e.g. attention, verbal fluency, and speed processing), disinhibition, loss of insight, perseveration, abnormal eating behaviour, agitation, insomnia, and depersonalization phenomena. Neuropsychological evaluation also revealed abnormal performance on the Trail Making and the Stroop tests. Besides typical demyelinating lesions and “black holes”, MRI showed a striking pattern of left frontal opercular involvement including cortical thinning, focal knife-edge appearance of the gyri, and marked gliosis in the adjacent white matter.DiscussionCognitive deficits in MS are typically subcortical, due to the expected predominance of white matter lesions. Nonetheless, the involvement of grey matter structures may contribute to a different pattern of cognitive dysfunction. For example, hippocampal involvement has been linked to memory impairment. This particular case report additionally illustrates how cortical grey matter involvement in the frontal lobe may lead (not unexpectedly) to a clinical condition mostly characterised by frontal deficits and psychiatric symptoms.

Problem solving by patients with multiple sclerosis Comparison of performance on the Wisconsin and California Card Sorting Tests

1996 ◽  
Vol 2 (2) ◽  
pp. 134-140 ◽  
Author(s):  
William W. Beatty ◽  
Nancy Monson
Keyword(s):  
Multiple Sclerosis ◽  
Problem Solving ◽  
Frontal Lobe ◽  
Concept Formation ◽  
Frontal Lobe Dysfunction ◽  
Card Sorting ◽  
Definite Multiple Sclerosis ◽  
Sorting Tests ◽  
Primary Deficit ◽  
Clinically Definite Multiple Sclerosis

AbstractProblem solving by patients with clinically definite multiple sclerosis (MS) was examined using the Wisconsin and California Card Sorting Tests (WCST and CCST). On the WCST, the MS patients achieved fewer categories and made more perseverative responses and errors than controls, confirming results of several previous studies. On the CCST, the MS patients generated and identified fewer concepts, but they performed normally when sorting was cued by the experimenter and they made no more persevcrations than controls. Although findings from the WCST indicate that the problem solving deficits by MS patients closely resemble those exhibited by patients with various conditions that produce frontal lobe dysfunction, results from the CCST indicate that the problem solving difficulties exhibited by patients with MS arc distinct and probably represent a primary deficit in concept formation. (JINS, 1996, 2, 134–140.)

NEUROREHABILITATION BY HIRUDOTHERAPY OF COGNITIVE IMPAIRMENT AFTER A CORONAVIRUS INFECTION

2021 ◽  
pp. 31-36
Author(s):  
С.Ж. СЕРИКБАЕВА ◽  
Н.Ж. ОРМАНОВ
Keyword(s):  
Cognitive Impairment ◽  
Frontal Lobe ◽  
Cognitive Disorders ◽  
Frontal Lobe Dysfunction ◽  
Voluntary Activity ◽  
Intellectual Activity ◽  
Moderate Cognitive Impairment ◽  
Coronavirus Infection ◽  
Positive Effect

В данной статье рассмотрены некоторые вопросы нейрореабилитации пациентов после коронавирусной инфекции (ПКВИ). Частыми осложнениями после перенесенного КВИ являются когнитивные расстройства, которые характеризовались снижением слухоречевой памяти, замедлением темпа интеллектуальной деятельности, уменьшением беглости речи, снижением концентрации внимания. Недостаточность регуляции произвольной деятельности, связанная с дисфункцией лобных долей является ведущим нейропсихологическим механизмом формирования когнитивных нарушений у пациентов после коранавирусной инфекции . Применение полного курса гирудотерапии оказывает позитивное влияние на умеренные когнитивные нарушения (УКН) у больных ПКВИ. This article discusses some issues of neurorehabilitation of patients after coronaviruses infection (PCWI). Frequent complications after CVI are cognitive disorders and harecterized by a decrease in auditoryspeech memory, a slowdown in the pace of intellectual activity, a decrease in fluency of speech, and a decrease in concentration. Lack of regulation of voluntary activity associated with frontal lobe dysfunction is the leading neuropsychological mechanism for the formation of cognitive impairment in patients with postcoranavirus infection . The use of a full course of hirudotherapy has a positive effect on moderate cognitive impairment (MCI) in patients with PCVI.

scholarly journals Cognitive impairment and depression in patients with relapsing–remitting multiple sclerosis depending on age and neuroimaging findings

2021 ◽  
Vol 57 (1) ◽  
Author(s):  
Oksana O. Kopchak ◽  
Tetiana A. Odintsova
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Corpus Callosum ◽  
Executive Functions ◽  
Frontal Lobe ◽  
Abstract Thinking ◽  
Visual Spatial ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis

Abstract Background Multiple sclerosis is an insidious, disabling, both physically and mentally, demyelinating disease of the central nervous system. This work aims to evaluate relationships between cognitive impairment in separate domains, depression and their correspondence with MRI-findings, as well as the influence on each other’s manifestations, in patients with relapsing–remitting multiple sclerosis. Results Visual–spatial/executive functions and memory domains suffered more frequently than others in the study subjects under 40 years; in patients over 40 years old memory, visual–spatial/executive functions and abstract thinking impairment prevailed the most. Such cognitive domains as memory, language, abstract thinking, visual–spatial and executive functions were impacted in both groups of patients even without the apparent cognitive decline according to MoCA scale. Presence of depression impacted language and attention more prominently than the rest of the domains only in participants younger 40 years. According to the MRI, frontal lobe, corpus callosum and periventricular area were affected more often compared to other brain regions in case of cognitive impairment; meanwhile, combined lesions of frontal lobe and corpus callosum, fronto-temporal region were associated with depression. Conclusion Cognitive impairment and depression are one of the common, yet disabling and socially disrupting manifestations of MS. Quite frequently such complaints are neglected or considered as parts of comorbidities. At the same time cognitive impairment can be amplified by depression, especially in patients under 40 years.

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