A follow-up study of Nordic multiple sclerosis candidate gene regions

2007 ◽  
Vol 13 (5) ◽  
pp. 584-589
Author(s):  
P. Datta ◽  
H.F. Harbo ◽  
L.P. Ryder ◽  
E. Akesson ◽  
J. Benedikz ◽  
...  

In this study, the results from three Nordic linkage disequilibrium screens in multiple sclerosis (MS) were investigated, in a new sample set of 314 Nordic MS trios from Denmark, Norway, Sweden and Iceland. Among 30 non-HLA and two HLA microsatellite markers individually genotyped, eight markers displayed distorted transmission with uncorrected P-value <0.05, ranked in this order: D6S2443 (6p21.32, HLA class II) (P corrected =0.01), D2S2201 (2p24), D19S552 (19q13), D3S3584 (3q21), D17S975 (17q11), D1S2627 (1p22), D6S273 (6p21.33, HLA class III) and D12S1051 (12q23). These non-HLA regions need further investigation as possible MS candidate gene regions in our population. Multiple Sclerosis 2007; 13: 584-589. http://msj.sagepub.com

2010 ◽  
Vol 33 (2) ◽  
pp. 169-175 ◽  
Author(s):  
Jorge Sepulcre ◽  
Herminia Peraita ◽  
Joaquín Goñi ◽  
Gonzalo Arrondo ◽  
Iñigo Martincorena ◽  
...  

2004 ◽  
Vol 56 (2) ◽  
pp. 303-306 ◽  
Author(s):  
Sean J. Pittock ◽  
Robyn L. McClelland ◽  
William T. Mayr ◽  
Neal W. Jorgensen ◽  
Brian G. Weinshenker ◽  
...  

2017 ◽  
Vol 372 ◽  
pp. 201
Author(s):  
Darija Kisic-Tepavcevic ◽  
Tatjana Pekmezovic ◽  
Goran Trajkovic ◽  
Nebojsa Stojsavljevic ◽  
Irena Dujmovic ◽  
...  

2011 ◽  
Vol 33 ◽  
pp. S12-S13 ◽  
Author(s):  
E. Venturini ◽  
L. Balugani ◽  
F. Zarattin ◽  
G. Ferraresi ◽  
S. Straudi ◽  
...  

2014 ◽  
Vol 85 (10) ◽  
pp. 1109-1115 ◽  
Author(s):  
Cecilie Jacobsen ◽  
Jesper Hagemeier ◽  
Kjell-Morten Myhr ◽  
Harald Nyland ◽  
Kirsten Lode ◽  
...  

2016 ◽  
Vol 6 (9) ◽  
Author(s):  
Morten Stilund ◽  
Mikkel Carstensen Gjelstrup ◽  
Tove Christensen ◽  
Holger Jon Møller ◽  
Thor Petersen

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Tadesse Tolossa ◽  
Getachew Mullu Kassa ◽  
Habtamu Chanie ◽  
Amanuel Abajobir ◽  
Diriba Mulisa

Abstract Objective Although Ethiopia has been implementing Option B+ program, LTFU of women from the Option B+ program is one of the challenges that minimizes its implementation. Thus, this study assessed the incidence and predictors of LTFU among women under Option B+ PMTCT program in western Ethiopia. An institution-based retrospective follow-up study was conducted. A cox proportional hazards regression model was fitted to identify predictors of LTFU. A Hazard ratios with 95% confidence CI was computed and all predictors that were associated with the outcome variable at p-value ≤ 0.05 in the multivariable cox proportional hazards were declared as a significance predictor of the outcome. Results A total of 330 women were followed for a mean follow up time of 16.9 (± 7.6) months. An overall incidence rate of LTFU was 9/1000 person-months. Women’s educational status, residence, HIV-disclosure status, the status of women at enrollment, previous history of HIV and ART adherence were significant predictors of LTFU. The incidence of LTFU from Option B+ PMTCT is lower as compared to evidence from sub-Saharan African and strengthening linkage and referral system between clinics as well as establishing appropriates tracing mechanisms would retain pregnant women in the program.


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