Detrimental role of granulocyte-colony stimulating factor in neuromyelitis optica: clinical case and histological evidence
2012 ◽
Vol 18
(12)
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pp. 1801-1803
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Keyword(s):
In a recent study, administration of granulocyte colony stimulating factor (G-CSF) increased neuromyelitis optica (NMO) lesions in mice. Here we report a patient whose first episode of NMO may have been exacerbated by inadvertent administration of G-CSF. Histological examination of brain and spinal cord samples from three other NMO patients revealed markedly increased expression of G-CSF in neurons located in and around the lesions, with little or no expression in multiple sclerosis lesions or normal white matter. Taken together, these cases support a detrimental role for G-CSF in NMO pathogenesis.
2005 ◽
Vol 175
(1)
◽
pp. 404-412
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2011 ◽
Vol 150
(5)
◽
pp. 594-598
1997 ◽
Vol 247
(1)
◽
pp. 386-395
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1993 ◽
pp. 189-202
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1992 ◽
Vol 298
(2)
◽
pp. 703-709
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