Human T Lymphotropic Virus Type I (Htlv-I)-Specific T Helper Cell Responses from Htlv-I Seronegative Patients with Chronic Myelopathy and Ms in Japan

1996 ◽  
Vol 1 (4) ◽  
pp. 200-203
Author(s):  
M Nishimura ◽  
S Jacobson ◽  
T Uchiyama ◽  
M Ohta ◽  
T Saida
Keyword(s):  
Virus Type ◽  
Neurological Diseases ◽  
Interleukin 2 ◽  
Spastic Paraparesis ◽  
Peripheral Blood Lymphocytes ◽  
Type I ◽  
T Lymphotropic Virus ◽  
Adult T Cell Leukemia ◽  
Progressive Myelopathy ◽  
Chronic Myelopathy

Human T lymphotropic virus type I (HTLV-I) is a human retrovirus etiologically linked to Adult T cell leukemia (ATL) and HTLV-I associated myelopathyltropical spastic paraparesis (HAM/TSP). Although most HAM/TSP patients have high anti-HTLV-I antibody titers in their sera, HTLV-I infected but seronegative patients with neurological diseases have been reported. To clarify whether seronegative, HTLV-I related neurological disease may exist, we have developed a method that measures the production of interleukin-2 (IL-2) from HTLV-I synthetic peptide-stimulated peripheral blood lymphocytes (PBL) of HTLV-I infected persons. This method is sensitive enough to detect exposure to HTLV-I before seroconversion or even before detection by PCR. We examined 12 patients with chronic progressive myelopathy and eight patients with multiple sclerosis (MS) in central Japan, where the prevalence rate of HTLV-I is between one and four percent among asymptomatic blood donors, using the IL-2 production assay. None of them were positive by the assay, suggesting seronegative HTLV-I myelopathy is very rare among patients with chronic progressive myelopathy and MS in Japan.

scholarly journals Case Report: Relevance of an Accurate Diagnosis and Monitoring of Infective Dermatitis Associated With Human T-Lymphotropic Virus Type 1 in Childhood

2021 ◽  
Vol 8 ◽  
Author(s):  
Paula Benencio ◽  
Nicolás Ducasa ◽  
Lourdes Arruvito ◽  
Inés Irurzun ◽  
Laura Praino ◽  
...  
Keyword(s):  
Virus Type ◽  
Buenos Aires ◽  
Spastic Paraparesis ◽  
Treatment Withdrawal ◽  
Full Blood Count ◽  
T Lymphotropic Virus ◽  
Adult T Cell Leukemia ◽  
Clinical Evaluations ◽  
Chronic Myelopathy

Human T-lymphotropic virus type 1 (HTLV-1) is a neglected retrovirus distributed worldwide and the ethiological agent of several pathologies, such as adult T-cell leukemia/lymphoma (ATLL), a chronic myelopathy known as HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated with HTLV-1 (IDH). HTLV-1 presents tropism for CD4+ T cells and induces deregulation of the cytokine profile. IDH is a severe, chronic superinfected eczema generally associated with Staphylococcus aureus and/or Streptococcus beta haemolyticus infection that responds partially to antibiotic therapy but prompt recurrence develops upon treatment withdrawal. IDH could be a risk factor for progression toward both HAM/TSP and ATLL and, similarly to other diseases associated with HTLV-1, it is sub-diagnosed particularly in non-endemic areas. Here, we present a case of IDH in a young boy living in Buenos Aires with symptoms since 2010, at the age of 5. HTLV-1 infection was suspected and confirmed in 2016. The patient exhibited chronic dermatosis with exudative eruption involving mainly the scalp, retroauricular regions, neck and abdomen. Clinical evaluations, routine laboratory tests, full blood count, and HTLV-1 diagnosis for this case are included.

scholarly journals Adult T-cell leukemia-lymphoma in a patient with HTLV-I/II associated myelopathy

1997 ◽  
Vol 55 (2) ◽  
pp. 325-328 ◽  
Author(s):  
Virgínia Freitas ◽  
Irenio Gomes ◽  
Achilea Bittencourt ◽  
Dilson Fernandes ◽  
Ailton Melo
Keyword(s):  
T Cell ◽  
Lymphoproliferative Disorder ◽  
Spastic Paraparesis ◽  
Type I ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
T Lymphotropic Virus ◽  
Adult T Cell Leukemia ◽  
The World ◽  
Chronic Myelopathy

Chronic myelopathy associated with T-lymphotropic virus type I (HAM) has been described as an endemic disease in several areas of the world, meanwhile there are few papers describing the association between HAM and adult T cell leukemia-lymphoma. We report the case of a man that, after four years of progressive spastic paraparesis and neurogenic bladder, developed a clinical picture of a lymphoproliferative disorder characterized by dermal and systemic envolvement, mimicking mycosis fungoides/Sézary syndrome.

Sex-specific mortality from adult T-cell leukemia among carriers of human T-lymphotropic virus type I

2001 ◽  
Vol 91 (4) ◽  
pp. 497-499 ◽  
Author(s):  
Michie Hisada ◽  
Akihiko Okayama ◽  
Donna Spiegelman ◽  
Nancy E. Mueller ◽  
Sherri O. Stuver
Keyword(s):  
T Cell ◽  
Virus Type ◽  
Type I ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
T Lymphotropic Virus ◽  
Adult T Cell Leukemia ◽  
Specific Mortality

scholarly journals Cohort Study of Hepatotropic Virus and Human T Lymphotropic Virus Type-I Infections in an Area Endemic for Adult T Cell Leukemia.

1991 ◽  
Vol 30 (6) ◽  
pp. 492-497 ◽  
Author(s):  
Shimeru KAMIHIRA ◽  
Saburo MOMITA ◽  
Shuichi IKEDA ◽  
Yasuaki YAMADA ◽  
Hisasi SOHDA ◽  
...  
Keyword(s):  
Cohort Study ◽  
T Cell ◽  
Virus Type ◽  
Type I ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
T Lymphotropic Virus ◽  
Adult T Cell Leukemia

Tropical Spastic Paraparesis: Lack of Human T-Lymphotropic Virus Type I Antibodies in Blood Donors From Bogota, Colombia

1988 ◽  
Vol 45 (3) ◽  
pp. 244-245
Author(s):  
G. C. Roman ◽  
L. N. Roman ◽  
J. L. Sever ◽  
D. L. Madden ◽  
B. S. Schoenberg ◽  
...  
Keyword(s):  
Virus Type ◽  
Blood Donors ◽  
Spastic Paraparesis ◽  
Tropical Spastic Paraparesis ◽  
Type I ◽  
T Lymphotropic Virus

Analyzing Interval Systems of Human T-Cell Lymphotropic Virus Type I Infection of CD4+ T-Cells

2017 ◽  
pp. 126-147
Author(s):  
Zohreh Dadi
Keyword(s):  
T Cell ◽  
Virus Type ◽  
Lupus Erythematosus ◽  
Dynamical Behavior ◽  
Spastic Paraparesis ◽  
Type I ◽  
Cell Dynamics ◽  
Adult T Cell Leukemia ◽  
Human T Cell ◽  
Study Interval

Human T-cell lymphotropic virus type I (HTLV-I) infects a type of white blood cell called a T lymphocyte. HTLV-I infection is seen in diverse region of the world such as the Caribbean Islands, southwestern Japan, southeastern United States, and Mashhad (Iran). This virus is the etiological agent of two main types of disease: HTLV-I-associated myelopathy/tropical spastic paraparesis and adult T cell leukemia. Also, the role of HTLV-I in the pathogenesis of autoimmune diseases such as HTLV-I associated arthropathy and systemic lupus erythematosus is under investigation. In this chapter, the author considers an ODE model of T-cell dynamics in HTLV-I infection which was proposed by Stilianakis and Seydel in 1999. Mathematical analysis of the model with fixed parameters has been done by many researchers. The author studies dynamical behavior (local stability) of this model with interval uncertainties, called interval system. Also, effective parameters in the local dynamics of model are found. For this study, interval analysis and particularly of Kharitonov's stability theorem are used.

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