scholarly journals Can findings from randomized controlled trials of social skills training in autism spectrum disorder be generalized? The neglected dimension of external validity

Autism ◽  
2015 ◽  
Vol 20 (3) ◽  
pp. 295-305 ◽  
Author(s):  
Ulf Jonsson ◽  
Nora Choque Olsson ◽  
Sven Bölte
Author(s):  
Mei L. Law ◽  
Jatinder Singh ◽  
Mathilde Mastroianni ◽  
Paramala Santosh

AbstractProdromal symptoms of Autism Spectrum Disorder (ASD) have been detected within the first year of life. This review evaluated evidence from randomized controlled trials (RCTs) of parent-mediated interventions for infants under 24 months who are at risk for ASD. Electronic databases, including grey literature, were searched up till November 2019. Seven RCTs were identified. There was substantial heterogeneity in recruitment, outcome measures and effect size calculations. Interventions did not reduce the risk of later ASD diagnosis and post-intervention effects on infant outcomes were inconsistent, with five studies reporting significant improvements across both treatment and control groups. Moderate level of evidence of intervention effects on parental interaction skills and the small number of RCTs, and significant limitations restrict generalizability across studies.


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